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Sleep quality in caregivers of patients with Alzheimer's disease and Parkinson's disease and its relationship to quality of life

Published online by Cambridge University Press:  01 June 2012

Chiara Cupidi ,
Sabrina Realmuto ,
Gianluca Lo Coco ,
Antonio Cinturino ,
Simona Talamanca ,
Valentina Arnao ,
Valentina Perini ,
Marco D'Amelio ,
Giovanni Savettieri  and
Daniele Lo Coco
Chiara Cupidi
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Sabrina Realmuto
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Gianluca Lo Coco
Affiliation:
Department of Psychology, Università di Palermo, Palermo, Italy
Antonio Cinturino
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Simona Talamanca
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Valentina Arnao
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Valentina Perini
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Marco D'Amelio
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Giovanni Savettieri
Affiliation:
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università di Palermo, Palermo, Italy
Daniele Lo Coco*
Affiliation:
Sleep Disorders Clinic, Dipartimento di Neuroscienze, Ospedale Civico – ARNAS, Palermo, Italy
*
Correspondence should be addressed to: Dr. Daniele Lo Coco, MD, PhD, Sleep Disorders Clinic, Dipartimento di Neuroscienze, Ospedale Civico – ARNAS, P.za N. Leotta, 4 – 90129 Palermo, Italy. Phone: +39 091 666 3005; Fax: +39 091 666 3006. Email: [email protected].
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Abstract

Background: Knowledge about sleep complaints of caregivers of patients with Alzheimer's disease (AD) and Parkinson's disease (PD) is limited, and we lack information about the relationship between caregivers’ sleep problems and their quality of life (QoL).

Methods: We evaluated subjective sleep quality and its relationship to QoL in a group of 80 caregivers of patients with AD (ADCG, n = 40) and PD (PDCG, n = 40), and in 150 controls. Information about night-time complaints was collected using the Pittsburgh Sleep Quality Index (PSQI). QoL was measured using the McGill QoL Questionnaire.

Results: Eighteen ADCG (45%), 22 PDCG (55%), and 45 (30%) controls reported poor sleep quality. Mean global PSQI score of PDCG (6.25 ± 3.9) was not significantly different from that of ADCG (5.8 ± 3.5; p = 0.67). However, both PDCG and ADCG scored significantly higher than control group (4.3 ± 3.1; p < 0.01). ADCG frequently reported difficulties falling asleep (72.5%) and disturbed sleep (100%). PDCG reported reduced subjective sleep quality (80%) and increased sleep disturbances (100%). Poor sleep quality was associated with depressive symptoms and correlated with QoL in caregivers of both groups, particularly the psychological symptoms domain.

Conclusions: Among caregivers of patients with AD and PD, poor sleep quality is frequent and significantly linked to QoL and depressive symptoms. Identifying the nature of sleep disturbances not only in patients but also in their caregivers is important as appropriate treatment may lead to a better management of the needs of families coping with these patients.

Keywords

Alzheimer's diseaseParkinson's diseaseneurodegenerative disorderscaregiverssleepdepressionquality of life
Type
Research Article
Information
International Psychogeriatrics , Volume 24 , Issue 11 , November 2012 , pp. 1827 - 1835
Copyright
Copyright © International Psychogeriatric Association 2012

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References

Baron, R. M. and Kenny, D. A. (1986). The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173–1182.CrossRefGoogle ScholarPubMed
Bastien, C. H., Vallières, A. and Morin, C. M. (2001). Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Medicine, 2, 297–307.CrossRefGoogle ScholarPubMed
Beck, A. et al. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.CrossRefGoogle ScholarPubMed
Belle, S. H. et al. (2006). Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: a randomized, controlled trial. Annals of Internal Medicine, 145, 727–738.CrossRefGoogle ScholarPubMed
Benca, R. M. (2001). Consequences of insomnia and its therapies. Journal of Clinical Psychiatry, 62 (Suppl 10), S33–S38.Google ScholarPubMed
Bliwise, D. L. et al. (1995). Disruptive nocturnal behavior in Parkinson's disease and Alzheimer's disease. Journal of Geriatric Psychiatry and Neurology, 8, 107–110.CrossRefGoogle ScholarPubMed
Buysse, D. J. et al. (1989). The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Research, 28, 193–213.CrossRefGoogle ScholarPubMed
Caap-Ahlgren, M. and Dehlin, O. (2001). Insomnia and depressive symptoms in patients with Parkinson's disease – relationship to health-related quality of life. An interview study of patients living at home. Archives of Gerontology and Geriatrics, 32, 23–33.CrossRefGoogle ScholarPubMed
Cohen, S. R. et al. (1995). The McGill Quality of Life Questionnaire: a measure of quality of life appropriate for people with advanced disease. A preliminary study of validity and acceptability. Palliative Medicine, 9, 207–219.CrossRefGoogle ScholarPubMed
Cohen, S. R. et al. (1996). Existential well-being is an important determinant of quality of life. Evidence from the McGill Quality of Life Questionnaire. Cancer, 77, 576–586.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Creese, J. et al. (2008). Sleep disturbances in spousal caregivers of individuals with Alzheimer's disease. International Psychogeriatrics, 20, 149–161.CrossRefGoogle ScholarPubMed
Cummings, J. L. et al. (1994). The Neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308–2314.CrossRefGoogle ScholarPubMed
Donaldson, C., Tarrier, N. and Burns, A. (1998). Determinants of carer stress in Alzheimer's disease. International Journal of Geriatric Psychiatry, 13, 248–256.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Fahn, S., Elton, R. L. and members of the UPDRS development committee (1987). Unified Parkinson's disease rating scale. In Fahn, S., Marsden, C. D., Calne, D. B. and Goldstein, M. (eds.), Recent Developments in Parkinson's Disease (pp. 153–163). Florham Park, NJ: MacMillan Health Care Information.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Gaugler, J. E. et al. (2000). Predictors of institutionalization of cognitively impaired elders: family help and the timing of placement. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 55, 247–255.CrossRefGoogle ScholarPubMed
Harper, D. G. et al. (2004). Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiology of Aging, 25, 771–781.CrossRefGoogle ScholarPubMed
Hoehn, M. M. and Yahr, M. D. (1967). Parkinsonism: onset, progression and mortality. Neurology, 17, 422–427.CrossRefGoogle ScholarPubMed
Hope, T. et al. (1998). Predictors of institutionalization for people with dementia living at home with a carer. International Journal of Geriatric Psychiatry, 13, 682–690.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
Kyle, S. D., Morgan, M. and Espie, C. A. (2010). Insomnia and health-related quality of life. Sleep Medicine Reviews, 14, 69–82.CrossRefGoogle ScholarPubMed
Leger, D. et al. (2001). SF-36: Evaluation of quality of life in severe and mild insomniacs compared with good sleepers. Psychosomatic Medicine, 63, 49–55.CrossRefGoogle ScholarPubMed
Martinez-Martin, P. et al. (2008). Burden, perceived health status, and mood among caregivers of Parkinson's disease patients. Movement Disorders, 23, 1673–1680.CrossRefGoogle ScholarPubMed
McCabe, M. P., Firth, L. and O'Connor, E. (2009). A comparison of mood and quality of life among people with progressive neurological illnesses and their caregivers. Journal of Clinical Psychology in Medical Settings, 16, 355–362.CrossRefGoogle ScholarPubMed
McCurry, S. M. et al. (2007). Sleep disturbances in caregivers of persons with dementia: contributing factors and treatment implications. Sleep Medicine Reviews, 11, 143–153.CrossRefGoogle ScholarPubMed
McKhann, G. et al. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
McKibbin, C. L. et al. (2005). Sleep in spousal caregivers of people with Alzheimer's disease. Sleep, 28, 1245–1250.CrossRefGoogle ScholarPubMed
Morin, C. M. (2004). Cognitive-behavioral approaches to the treatment of insomnia. Journal of Clinical Psychiatry, 65 (Suppl 16), 33–40.Google Scholar
Morris, J. C. (1993). The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology, 43, 2412–2414.CrossRefGoogle ScholarPubMed
Neikrug, A. B. and Ancoli-Israel, S. (2010). Sleep disturbances in nursing homes. Journal of Nutrition, Health and Aging, 14, 207–211.CrossRefGoogle ScholarPubMed
Novak, M. and Guest, C. (1989). Application of a multidimensional caregiver burden inventory. Gerontologist, 29, 798–803.CrossRefGoogle ScholarPubMed
Pal, P. K. et al. (2004). Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson's disease and in their caregivers. Parkinsonism & Related Disorders, 10, 157–168.CrossRefGoogle ScholarPubMed
Pollak, C. P. and Perlick, D. (1991). Sleep problems and institutionalization of the elderly. Journal of Geriatric Psychiatry and Neurology, 4, 204–210.CrossRefGoogle ScholarPubMed
Raggi, A. and Ferri, R. (2010). Sleep disorders in neurodegenerative diseases. European Journal of Neurology, 17, 1326–1338.CrossRefGoogle ScholarPubMed
Rosch, P. J. (1996). Stress and sleep: some startling and sobering statistics. Stress Medicine, 12, 207–210.3.0.CO;2-8>CrossRefGoogle Scholar
Smith, M. C., Ellgring, H. and Oertel, W. H. (1997). Sleep disturbances in Parkinson's disease patients and spouses. Journal of the American Geriatrics Society, 45, 194–199.CrossRefGoogle ScholarPubMed
Välimäki, T. H. et al. (2009). Caregiver depression is associated with a low sense of coherence and health-related quality of life. Aging & Mental Health, 13, 799–807.CrossRefGoogle ScholarPubMed
Vitiello, M. V. and Borson, S. (2001). Sleep disturbances in patients with Alzheimer's disease. CNS Drugs, 15, 777–796.CrossRefGoogle ScholarPubMed
Zammit, G. K. et al. (1999). Quality of life in people with insomnia. Sleep, 22 (Suppl), S379–S385.Google ScholarPubMed
Zeitlhofer, J. et al. (2000). Sleep and quality of life in the Austrian population. Acta Neurologica Scandinavica, 102, 249–257.CrossRefGoogle ScholarPubMed