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Sensitivity to change of composite and frequency scores of the Neuropsychiatric Inventory in mild to moderate dementia

Published online by Cambridge University Press:  30 November 2012

Jeffrey L. Cummings ,
Ralf Ihl ,
Horst Herrschaft ,
Robert Hoerr  and
Michael Tribanek
Jeffrey L. Cummings
Affiliation:
Lou Ruvo Center for Brain Health, The Andrea L. and Joseph F. Hahn MD Chair of Neurotherapeutics, Cleveland Clinic, Las Vegas, NV, USA
Ralf Ihl
Affiliation:
Alexian Hospital Krefeld and Department of Psychiatry, University of Duesseldorf, Duesseldorf, Germany
Horst Herrschaft
Affiliation:
Medical Faculty, University of Cologne, Cologne, Germany
Robert Hoerr*
Affiliation:
Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany
Michael Tribanek
Affiliation:
Statistician, Hamburg, Germany
*
Correspondence should be addressed to: Robert Hoerr, MD, PhD, Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG, Willmar-Schwabe-Str. 4, 76227 Karlsruhe, Germany. Phone: +49 721 4005-492; Fax: +49 721 4005-8492. Email: [email protected].
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Abstract

Background: The Neuropsychiatric Inventory (NPI) is widely used to assess psychopathology in dementia. The scoring involves ratings of frequency and severity, as well as the calculation of a composite score. It was suggested recently that, due to lower variance, the frequency score might be more sensitive to detect treatment-related change and to discriminate active treatment from placebo than the composite score, particularly in milder forms of the disease.

Methods: Based on data from three randomized controlled trials in patients with mild to moderate dementia, standardized changes were calculated for both frequency and composite scores for two strata of disease severity. The two strata were formed by dichotomizing the sample along the median score of the short cognitive performance test (SKT) battery.

Results: Across all studies and for both severity strata, standardized changes in frequency scores were not consistently larger than those in composite scores and both scores discriminated active treatment from placebo at similar probabilities for type-1 error.

Conclusion: Our findings do not support the notion that there is a difference between frequency score and composite score with respect to their sensitivity to treatment-related change.

Keywords

assessmentbehaviorNPIpsychometric properties
Type
Research Article
Information
International Psychogeriatrics , Volume 25 , Issue 3 , March 2013 , pp. 431 - 438
Copyright
Copyright © International Psychogeriatric Association 2012

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