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Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease

Published online by Cambridge University Press:  15 December 2009

Tomoyuki Nagata ,
Shunichiro Shinagawa ,
Yusuke Ochiai ,
Hirohide Kada ,
Hiroo Kasahara ,
Kazutaka Nukariya  and
Kazuhiko Nakayama
Tomoyuki Nagata*
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Shunichiro Shinagawa
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
Yusuke Ochiai
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Hirohide Kada
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Hiroo Kasahara
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Kazutaka Nukariya
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
Kazuhiko Nakayama
Affiliation:
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
*
Correspondence should be addressed to: Tomoyuki Nagata, Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, 163–1 Kashiwashita, Kashiwa, Chiba 277–8567, Japan. Phone: +81-4-7164-1111; Fax: +81-4-7164-9374. Email: [email protected].
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Abstract

Background: In order to address the neuropsychological pathogenesis of aberrant motor behaviors in Alzheimer's disease (AD), we used a cross-sectional study design to investigate the association between frontal lobe function, including executive function, and activity disturbances (wandering, purposeless activities and inappropriate activities).

Methods: Among 75 consecutive outpatients with AD, 50 subjects with a Clinical Dementia Rating (CDR) score of 1 or 2 were selected and divided into two groups based on data obtained from interviews with their caregivers: an aberrant motor behaviors (AMB) group (n = 22), and a non-aberrant motor behaviors (NAMB) group (n = 28). Aberrant motor behavior was defined according to whether the “activity disturbance” score (ranging from 0 to 9) of the Behavioral Pathology in Alzheimer Disease (Behave-AD) scale was 0 or ≥1. The total and subtest scores of the Frontal Assessment Battery (FAB) were then compared between the two groups.

Results: Significant differences were found between the FAB total (P < 0.05) and the subtest scores (lexical fluency, conflicting instructions; P < 0.05) in the two groups. The FAB score was significantly associated with the activity disturbance score (r = −0.49; P<0.001). A stepwise multiple regression analysis showed that only the FAB score significantly influenced the activity disturbance score (P < 0.001).

Conclusions: This finding suggested that in addition to episodic memory disturbance, frontal lobe dysfunctions might lead patients with AD to develop aberrant motor behavior.

Keywords

Frontal Assessment Batterydementiaactivity disturbanceswanderingexecutive function
Type
Research Article
Information
International Psychogeriatrics , Volume 22 , Issue 3 , May 2010 , pp. 463 - 469
Copyright
Copyright © International Psychogeriatric Association 2009

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