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Regional Brain Atrophy in Patients With Mild Alzheimer's Disease and Delusions

Published online by Cambridge University Press:  10 January 2005

Cristina Geroldi ,
Lorena Bresciani ,
Orazio Zanetti  and
Giovanni B. Frisoni
Cristina Geroldi
Affiliation:
Laboratory of Epidemiology & Neuroimaging, IRCCS San Giovanni di Dio—FBF, Brescia, Italy. Alzheimer's Unit, IRCCS San Giovanni di Dio—FBF, Brescia, Italy.
Lorena Bresciani
Affiliation:
Laboratory of Epidemiology & Neuroimaging, IRCCS San Giovanni di Dio—FBF, Brescia, Italy.
Orazio Zanetti
Affiliation:
Alzheimer's Unit, IRCCS San Giovanni di Dio—FBF, Brescia, Italy.
Giovanni B. Frisoni
Affiliation:
Laboratory of Epidemiology & Neuroimaging, IRCCS San Giovanni di Dio—FBF, Brescia, Italy.
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Abstract

Background and Objective: The pathophysiology and the neurobiology of the behavioral disturbances in Alzheimer's disease (AD) are far from understood. The aim of the study was to assess whether delusional AD patients have a specific pattern of regional brain atrophy. Methods: The setting of the study was the outpatients facility of a memory clinic. Subjects were 41 AD patients with mild dementia severity (Mini-Mental State Exam score of 22 ± 3, range 18 to 27). Delusions were assessed with the pertinent subscale of the UCLA Neuropsychiatric Inventory (NPI). Nondelusional (n = 22) AD and delusional (n = 19) AD were defined on the basis of absence (NPI delusions subscale = 0) or presence (NPI delusions subscale = 1 or higher) of delusions. Thirteen (68%) of the delusional patients had isolated theft delusions, and 6 (32%) had theft associated with another paranoid delusion (of jealousy or persecution). None of the patients had misidentifications or other delusions of nonparanoid content. Temporal lobe and frontal lobe atrophy were assessed with linear measures (radial width of the temporal horn, rWTH, and frontal index, FI) taken from computed tomographic films. Temporal and frontal asymmetries were computed as right/left ratio of the rWTH and FI. Results: AD patients without delusions had symmetrical enlargement of both temporal (8.1 ± 3.9 vs. 8.5 ± 4.5) and frontal horns (35.8 ± 4.8 vs. 35.9 ± 4.6). On the contrary, AD with delusions showed temporal horns larger to the right (9.1 ± 3.3 vs. 7.7 ± 3.1, p = .06) and the frontal horn to the left (35.7 ± 4.3 vs. 37.5 ± 4.2, p = .02). This different pattern was confirmed with a gender-adjusted repeated measures analysis of variance model (interaction term between asymmetry and group: F1,38 = 5.5, p = .03). Discussion: AD patients with delusions are characterized by a specific pattern of frontal and temporal asymmetry of brain atrophy, whereas nondelusional patients are symmetric. Because the asymmetry pattern of the delusional patients is similar to the physiological pattern of asymmetry of individuals without dementia, the data indicate that the absence of theft delusions in the mild stage of AD rather than their presence is associated with an abnormal asymmetry pattern.

Keywords

Theft delusionCT scantemporal lobe asymmetryfrontal lobe asymmetry
Type
Articles
Information
International Psychogeriatrics , Volume 14 , Issue 4 , December 2002 , pp. 365 - 378
Copyright
© 2002 International Psychogeriatric Association

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