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Mutational and Susceptibility Genetics Are Different Clinical Paradigms

Published online by Cambridge University Press:  10 January 2005

Allen D. Roses
Allen D. Roses
Affiliation:
Center for Human Genetics, Departments of Medicine, (Neurology) and Neurobiology, Duke University Medical Center, Durham, NC, USA

Extract

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During the past 2 years there have been several consensus conferences on diagnostic testing for Alzheimer's disease (AD), specifically related to the use of new genetic tests (Farrer et al., 1995; Relkin et al., 1996). Unfortunately there is an appearance of controversy between some of the published opinions and the empirical data (Saunders et al., 1996; Slooter et al., 1996). The clinical paradigm for AD has changed from “ruling out” a small list of reversible and treatment causes of dementia to “ruling in” the diagnosis of AD using adjunctive genetic tests with a high positive predictive value for some patients (Roses & Saunders, in press).

Type
Guest Editorials
Information
International Psychogeriatrics , Volume 9 , Issue 1 , March 1997 , pp. 7 - 10
Copyright
© 1997 International Psychogeriatric Association