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MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17)

Published online by Cambridge University Press:  01 December 2016

Robert Haussmann ,
Marek Wysocki ,
Moritz D. Brandt ,
Andreas Hermann  and
Markus Donix
Robert Haussmann*
Affiliation:
Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Marek Wysocki
Affiliation:
Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Moritz D. Brandt
Affiliation:
Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Andreas Hermann
Affiliation:
Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany German Center for Neurodegenerative Diseases (DZNE), Research Site Dresden, Dresden, Germany
Markus Donix
Affiliation:
Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany German Center for Neurodegenerative Diseases (DZNE), Research Site Dresden, Dresden, Germany
*
Correspondence should be addressed to: Robert Haussmann, MD, Fetscherstraße 74, 01307 Dresden, Germany. Phone: +49351-458-3561; Fax: +49351-458-5380. Email: robert.haussmann@uniklinikum-dresden.
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Abstract

We present a 56-year-old patient suffering from frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). The history included a three-generation pedigree and the patient was found to be a mutation carrier. The diagnosis was hindered by late appearance of the hypokinetic movement disorder. For clinicians, it is important to consider rare neurodegenerative disease variants in early-onset familial dementia syndromes with behavioral, cognitive, and motor symptoms.

Keywords

frontotemporal dementiadementiageneticsParkinson's disease
Type
Case Report
Information
International Psychogeriatrics , Volume 29 , Issue 5 , May 2017 , pp. 869 - 871
Copyright
Copyright © International Psychogeriatric Association 2016 

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