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Management of delirium in older adults: challenges and opportunities

Published online by Cambridge University Press:  16 April 2021

Kathleen S. Bingham  and
Alastair J. Flint
Kathleen S. Bingham*
Affiliation:
Department of Psychiatry, University of Toronto, Toronto, ON, Canada Centre for Mental Health, University Health Network, Toronto, ON, Canada
Alastair J. Flint
Affiliation:
Department of Psychiatry, University of Toronto, Toronto, ON, Canada Centre for Mental Health, University Health Network, Toronto, ON, Canada
*
Email: [email protected]
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Abstract

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Type
Commentary
Information
International Psychogeriatrics , Volume 34 , Special Issue 10: Issue Theme: Pharmacotherapy for Serious Neuropsychiatric Disorders , October 2022 , pp. 861 - 864
Copyright
© International Psychogeriatric Association 2021

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References

Burry, L. et al. (2018). Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews, 2018, Issue 6, Art. No.: CD005594. https://doi.org/10.1002/14651858.CD005594.pub3 CrossRefGoogle Scholar
Dighe, K., Clarke, H., McCartney, C. J. and Wong, C. L. (2014). Perioperative gabapentin and delirium following total knee arthroplasty: a post-hoc analysis of a double-blind randomized placebo-controlled trial. Canadian Journal of Anesthesia, 61, 1136–1137. https://doi.org/10.1007/s12630-014-0235-5 CrossRefGoogle ScholarPubMed
Fabritius, M. L. et al. (2017). Benefit and harm of pregabalin in acute pain treatment: a systematic review with meta-analyses and trial sequential analyses. British Journal of Anesthesia, 119, 775–791. https://doi.org/10.1093/bja/aex227 CrossRefGoogle ScholarPubMed
Farlinger, C., Clarke, H. and Wong, C. L. (2018). Perioperative pregabalin and delirium following total hip arthroplasty: a post hoc analysis of a double-blind randomized placebo-controlled trial. Canadian Journal of Anesthesia, 65, 1269–1270. https://doi.org/10.1007/s12630-018-1195-y CrossRefGoogle ScholarPubMed
Flükiger, J. et al. (2018). Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. Annals of Intensive Care, 8, 92. https://doi.org/10.1186/s13613-018-0437-z CrossRefGoogle ScholarPubMed
Gupta, A. et al. (2022). Is there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults? International Psychogeriatrics, 34, 889–903. https://doi.org/10.1017/S1041610221000235 CrossRefGoogle ScholarPubMed
Hshieh, T. T. et al. (2015). Effectiveness of multi-component non-pharmacologic delirium interventions: A Meta-analysis. JAMA Internal Medicine, 175, 512–520. https://doi.org/10.1001/jamainternmed.2014.7779 CrossRefGoogle Scholar
Inouye, S. K. et al. (1999). A Multicomponent intervention to prevent delirium in hospitalized older patients. New England Journal of Medicine, 340, 669–676. https://doi.org/10.1056/NEJM199903043400901 CrossRefGoogle ScholarPubMed
Inouye, S. K., Leo-Summers, L., Zhang, Y., Bogardus, S. T., Leslie, D. L. and Agostini, J. V. (2005). A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. Journal of the American Geriatrics Society, 53, 312–318. https://doi.org/10.1111/j.1532-5415.2005.53120.x CrossRefGoogle ScholarPubMed
Inouye, S. K., van Dyck, C. H., Alessi, C. A., Balkin, S., Siegal, A. P. and Horwitz, R. I. (1990). Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Annals of Internal Medicine, 113, 941–948. https://doi.org/10.7326/0003-4819-113-12-941 CrossRefGoogle Scholar
Leung, J. M. et al. 2017. Perioperative gabapentin does not reduce postoperative delirium in older surgical patients: A randomized clinical trial. Anesthesiology, 127, 633–644. https://doi.org/10.1097/ALN.0000000000001804 CrossRefGoogle Scholar
Leung, J. M. et al. (2006). Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology, 67, 1251–1253. https://doi.org/10.1212/01.wnl.0000233831.87781.a9 CrossRefGoogle ScholarPubMed
Morandi, A. et al. (2017). The diagnosis of delirium superimposed on dementia: An emerging challenge. Journal of the American Medical Directors Association, 18, 12–18. https://doi.org/10.1016/j.jamda.2016.07.014 CrossRefGoogle Scholar
Morandi, A. et al. (2012). Tools to detect delirium superimposed on dementia: A systematic review. Journal of the American Geriatrics Society, 60, 2005–2013. https://doi.org/10.1111/j.1532-5415.2012.04199.x CrossRefGoogle ScholarPubMed
Oh, E. S., Fong, T. G., Hshieh, T. T. and Inouye, S. K. (2017). Delirium in older persons. JAMA, 318, 1161–1174. https://doi.org/10.1001/jama.2017.12067 CrossRefGoogle ScholarPubMed
Rose, L. et al. (2017) Development of core outcome sets for effectiveness trials of interventions to prevent and/or treat delirium (Del-COrS): study protocol. BMJ Open, 7, e016371. https://doi.org/10.1136/bmjopen-2017-016371 CrossRefGoogle ScholarPubMed
Sher, Y., Miller Cramer, A. C., Ament, A., Lolak, S. and Maldonado, J. R. (2015). Valproic acid for treatment of hyperactive or mixed delirium: rationale and literature review. Psychosomatics, 56, 615–625. https://doi.org/10.1016/j.psym.2015.09.008 CrossRefGoogle ScholarPubMed
Shi, Q., Warren, L., Saposnik, G. and Macdermid, J. C. (2013). Confusion assessment method: a systematic review and meta-analysis of diagnostic accuracy. Neuropsychiatric Disease and Treatment, 9, 1359–1370. https://doi.org/10.2147/NDT.S49520 CrossRefGoogle ScholarPubMed
Siddiqi, N., House, A. O. and Holmes, J. D. (2006). Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age and Ageing, 35, 350–364. https://doi.org/10.1093/ageing/afl005 CrossRefGoogle ScholarPubMed