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Hippocampal atrophy in people with memory deficits: results from the population-based IPREA study

Published online by Cambridge University Press:  13 February 2014

Luca Ferrarini ,
Baldur van Lew ,
Johan H. C. Reiber ,
Claudia Gandin ,
Lucia Galluzzo ,
Emanuele Scafato ,
Giovanni B. Frisoni ,
Julien Milles  and
Michela Pievani
Luca Ferrarini
Affiliation:
LKEB – Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands Campus IFOM-IEO, Milan, Italy
Baldur van Lew
Affiliation:
LKEB – Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Johan H. C. Reiber
Affiliation:
LKEB – Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Claudia Gandin
Affiliation:
National Center on Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy
Lucia Galluzzo
Affiliation:
National Center on Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy
Emanuele Scafato
Affiliation:
National Center on Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome, Italy
Giovanni B. Frisoni*
Affiliation:
Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland
Julien Milles
Affiliation:
LKEB – Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Michela Pievani
Affiliation:
Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, Brescia, Italy
*
Correspondence should be addressed to: Giovanni B. Frisoni, MD, Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Istituto Centro San Giovanni di Dio, Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy. Phone: +39-030-3501361; Fax: +39-030-3501592. Email: [email protected].
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Abstract

Background:

Clinical studies have shown that hippocampal atrophy is present before dementia in people with memory deficits and can predict dementia development. The question remains whether this association holds in the general population. This is of interest for the possible use of hippocampal atrophy to screen population for preventive interventions. The aim of this study was to assess hippocampal volume and shape abnormalities in elderly adults with memory deficits in a cross-sectional population-based study.

Methods:

We included individuals participating in the Italian Project on the Epidemiology of Alzheimer Disease (IPREA) study: 75 cognitively normal individuals (HC), 31 individuals with memory deficits (MEM), and 31 individuals with memory deficits not otherwise specified (MEMnos). Hippocampal volumes and shape were extracted through manual tracing and the growing and adaptive meshes (GAMEs) shape-modeling algorithm. We investigated between-group differences in hippocampal volume and shape, and correlations with memory deficits.

Results:

In MEM participants, hippocampal volumes were significantly smaller than in HC and were mildly associated with worse memory scores. Memory-associated shape changes mapped to the anterior hippocampus. Shape-based analysis detected no significant difference between MEM and HC, while MEMnos showed shape changes in the posterior hippocampus compared with HC and MEM groups.

Conclusions:

These findings support the discriminant validity of hippocampal volumetry as a biomarker of memory impairment in the general population. The detection of shape changes in MEMnos but not in MEM participants suggests that shape-based biomarkers might lack sensitivity to detect Alzheimer's-like pathology in the general population.

Keywords

hippocampal atrophymemoryMRIpopulation-based
Type
Research Article
Information
International Psychogeriatrics , Volume 26 , Issue 7 , July 2014 , pp. 1067 - 1081
Copyright
Copyright © International Psychogeriatric Association 2014 

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