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Gullibility may be a warning sign of Alzheimer's disease dementia

Published online by Cambridge University Press:  25 June 2018

Tomoharu Yamaguchi ,
Yohko Maki ,
Masamitsu Takatama  and
Haruyasu Yamaguchi
Tomoharu Yamaguchi*
Affiliation:
Department of Rehabilitation, Gunma University of Health and Welfare, Gunma, Japan Gunma University Graduate School of Health Sciences, Gunma, Japan
Yohko Maki
Affiliation:
National Center for Geriatrics and Gerontology, Aichi, Japan
Masamitsu Takatama
Affiliation:
Geriatrics Research Institute and Hospital, Gunma, Japan
Haruyasu Yamaguchi
Affiliation:
Gunma University Graduate School of Health Sciences, Gunma, Japan Tokyo Dementia Care Research and Training Center, Tokyo, Japan
*
Correspondence should be addressed to: Tomoharu Yamaguchi, 6/F, Maebashi Plaza Genki 21 Building, 2-12-1 Hon-machi, Maebashi, Gunma 371-0023, Japan. Phone: +81-27-210-1294; Fax: +81-27-260-1294. Email: [email protected].
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Abstract

Background:

Theory of Mind reasoning, which plays a pivotal role in social interaction, is required to detect deception. Empirically, those with cognitive decline are vulnerable to deception.

Methods:

Participants were 45 healthy elderly adults with clinical dementia rating (CDR) 0, and 76 outpatients: 25 with amnestic mild cognitive impairment (aMCI, CDR 0.5), 34 with mild Alzheimer's disease dementia (ADD, CDR 1), and 17 with moderate ADD (CDR 2). The task consisted of two single-frame cartoons that depicted a character with an intention to deceive another character using social signs of gaze and pointing, and participants are provided clue questions to detect the character's intentions.

Results:

The percentage of participants who detected the character's intention decreased with ADD progression (CDR 0, 82.2%; CDR 0.5, 48.0%; CDR 1, 29.4%; and CDR 2, 0%). Total score (0–6) also decreased with ADD progression (CDR 0, 4.4 +/−1.1; CDR 0.5, 3.0 +/−1.3; CDR 1, 2.9 +/−1.5; and CDR 2, 1.6 +/−0.9).

Discussion and Conclusions:

The present study demonstrated that those with aMCI have difficulty in detecting other's deceiving intentions, when the intention was shown implicitly using social signs. In a previous study, we have reported that mild ADD showed difficulties in detecting intention, while aMCI succeeded in detection when the intention was depicted explicitly. These results together suggested that those with aMCI is vulnerable to deception when the intention was shown implicitly using non-verbal cues, while ADD may fail to detect the intention even when the intention was shown explicitly.

Keywords

dementiacarersAlzheimer's disease (AD)
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 3: Issue Theme: Caregiving for People with Dementia , March 2019 , pp. 363 - 370
Copyright
Copyright © International Psychogeriatric Association 2018 

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References

Adolphs, R. (2003). Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience, 4, 165–178.Google Scholar
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn, DSM-5. Washington, DC: American Psychiatric Publishing.Google Scholar
Bora, E., Walterfang, M. and Velakoulis, D. (2015). Theory of mind in behavioural-variant frontotemporal dementia and Alzheimer's disease: a meta-analysis. Journal of Neurology, Neurosurgery, and Psychiatry, 86, 714–719.Google Scholar
Byom, L. J. and Mutlu, B. (2013). Theory of mind: mechanisms, methods, and new directions. Frontiers in Human Neuroscience, 7, 413.Google Scholar
Castelli, I. et al. (2011). Mapping levels of theory of mind in Alzheimer's disease: a preliminary study. Aging & Mental Health, 15, 157–168.Google Scholar
Cuerva, A. G., Sabe, L., Kuzis, G., Tiberti, C., Dorrego, F. and Starkstein, S. E. (2001). Theory of mind and pragmatic abilities in dementia. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 14, 153–158.Google Scholar
Dennett, D. (1978). Beliefs about beliefs. Behavioral and Brain Sciences, 1, 568–570.Google Scholar
Dubois, B. et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. The Lancet Neurology, 6, 734–746.Google Scholar
Fernandez-Duque, D., Baird, J. A. and Black, S. E. (2009). False-belief understanding in frontotemporal dementia and Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 31, 489–497.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.Google Scholar
Freedman, M., Binns, M. A., Black, S. E., Murphy, C. and Stuss, D. T. (2012). Theory of mind and recognition of facial emotion in dementia: challenge to current concepts. Alzheimer Disease & Associated Disorders, 27, 56–61.Google Scholar
Frith, C. and Frith, U. (2005). Theory of mind. Current Biology, 15, R644–R646.Google Scholar
Gitlin, L. N., Winter, L., Dennis, M. P. and Hauck, W. W. (2007). A non-pharmacological intervention to manage behavioral and psychological symptoms of dementia and reduce caregiver distress: design and methods of project ACT3. Clinical Interventions in Aging, 2, 695–703.Google Scholar
Gregory, C. et al. (2002). Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications. Brain, 125, 752–764.Google Scholar
Le Bouc, R. et al. (2012). My belief or yours? Differential theory of mind deficits in frontotemporal dementia and Alzheimer's disease. Brain, 135, 3026–3038.Google Scholar
Maki, Y. et al. (2012). Effects of intervention using a community-based walking program for prevention of mental decline: a randomized controlled trial. Journal of the American Geriatrics Society, 60, 505–510.Google Scholar
Maki, Y., Yamaguchi, T., Koeda, T. and Yamaguchi, H. (2013). Communicative competence in Alzheimer's disease: metaphor and sarcasm comprehension. American Journal of Alzheimers Disease & Other Dementias, 28, 69–74.Google Scholar
Moreau, N., Rauzy, S., Viallet, F. and Champagne-Lavau, M. (2016). Theory of mind in Alzheimer disease: evidence of authentic impairment during social interaction. Neuropsychology, 30, 312–321.Google Scholar
Narme, P., Mouras, H., Roussel, M., Devendeville, A. and Godefroy, O. (2013). Assessment of socioemotional processes facilitates the distinction between frontotemporal lobar degeneration and Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 35, 728–744.Google Scholar
Petersen, R. C. (2007). Mild cognitive impairment: current research and clinical implications. Seminars in Neurology, 27, 22–31.Google Scholar
Pinquart, M. and Sorensen, S. (2003). Associations of stressors and uplifts of caregiving with caregiver burden and depressive mood: a meta-analysis. The Journal of Gerontology. Series B, Psychological Sciences and Social Sciences, 58, P112–128.Google Scholar
Poletti, M. and Bonuccelli, U. (2013). Alteration of affective theory of mind in amnestic mild cognitive impairment. Journal of Neuropsychology, 7, 121–131.Google Scholar
Potkins, D. et al. (2003). Language impairment in dementia: impact on symptoms and care needs in residential homes. International Journal of Geriatric Psychiatry, 18, 1002–1006.Google Scholar
Premack, D. and Woodruff, G. (1978). Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences, 1, 515–526.Google Scholar
Reisberg, B., Ferris, S. H., Kluger, A., Franssen, E., Wegiel, J. and de Leon, M. J. (2008). Mild cognitive impairment (MCI): a historical perspective. International Psychogeriatrics, 20, 18–31.Google Scholar
Sandoz, M., Demonet, J. F. and Fossard, M. (2014). Theory of mind and cognitive processes in aging and Alzheimer type dementia: a systematic review. Aging & Mental Health, 18, 815–827.Google Scholar
Schulz, R. and Beach, S. R. (1999). Caregiving as a risk factor for mortality: the caregiver health effects study. JAMA, 282, 2215–2219.Google Scholar
Shany-Ur, T. et al. (2012). Comprehension of insincere communication in neurodegenerative disease: lies, sarcasm, and theory of mind. Cortex, 48, 1329–1341.Google Scholar
Wimmer, H. and Perner, J. (1983). Beliefs about beliefs: representation and constraining function of wrong beliefs in young children's understanding of deception. Cognition, 13, 103–128.Google Scholar
Yamaguchi, T., Maki, Y. and Yamaguchi, H. (2012). Pitfall intention explanation task with clue questions (Pitfall task): assessment of comprehending other people's behavioral intentions in Alzheimer's disease. International Psychogeriatrics, 24, 1919–1926.Google Scholar
Zaitchik, D., Koff, E., Brownell, H., Winner, E. and Albert, M. (2004). Inference of mental states in patients with Alzheimer's disease. Cognitive Neuropsychiatry, 9, 301–313.Google Scholar