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The Effects of Mood Changes and Antidepressants on the Cognitive Capacity of Elderly Depressed Patients

Published online by Cambridge University Press:  07 January 2005

Anastasios Georgotas ,
Robert E. McCue ,
Barry Reisberg ,
Steven H. Ferris ,
Narmada Nagachandran ,
Irene Chang  and
Pervez Mir
Anastasios Georgotas
Affiliation:
New York University Medical Center and School of Medicine, New York
Robert E. McCue
Affiliation:
New York University Medical Center and School of Medicine, New York
Barry Reisberg
Affiliation:
New York University Medical Center and School of Medicine, New York
Steven H. Ferris
Affiliation:
New York University Medical Center and School of Medicine, New York
Narmada Nagachandran
Affiliation:
New York University Medical Center and School of Medicine, New York
Irene Chang
Affiliation:
New York University Medical Center and School of Medicine, New York
Pervez Mir
Affiliation:
New York University Medical Center and School of Medicine, New York
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Abstract

Seventy-eight nondemented elderly depressed patients underwent an extensive battery of cognitive tess both before and after seven weeks of treatment with nortriptyline, phenelzine, or placebo. Clinical and cognitive evaluations of the patients were under double-blind conditions. Response to treatment did not appear to significantly affect cognitive capacity; neither did treatment with an active substance as compared to placebo. In addition, the baseline level of cognitive functioning did not appear related to whether a patient responded to treatment. The authors conclude that under optimal conditions neither antidepressant produces measurable changes in the cognitive capacity of nondemented elderly patients.

Type
Research and Reviews
Information
International Psychogeriatrics , Volume 1 , Issue 2 , September 1989 , pp. 135 - 143
Copyright
© 1989 Springer Publishing Company

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