Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-20T09:23:22.302Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of age, education and gender in the Consortium to Establish a Registry for the Alzheimer's Disease (CERAD)-Neuropsychological Assessment Battery for Cantonese-speaking Chinese elders

Published online by Cambridge University Press:  05 July 2011

Karen P. Y. Liu ,
Michael C. C. Kuo ,
Kin-chung Tang ,
Allison W. S. Chau ,
Iris H. T. Ho ,
Matthew P. H. Kwok ,
Wallis C. W. Chan ,
Roy H. K. Choi ,
Natalie C. W. Lam  and
Mary M. L. Chu
...Show all authors
Karen P. Y. Liu*
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Michael C. C. Kuo
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Kin-chung Tang
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Allison W. S. Chau
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Iris H. T. Ho
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Matthew P. H. Kwok
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Wallis C. W. Chan
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Roy H. K. Choi
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Natalie C. W. Lam
Affiliation:
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong
Mary M. L. Chu
Affiliation:
Occupational Therapy Department, Queen Mary Hospital, Hong Kong
Leung-wing Chu
Affiliation:
Department of Medicine, Queen Mary Hospital, Hong Kong
*
Correspondence should be addressed to: Karen Liu, PhD, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Phone: +852 2766 4801; Fax: +852 2330 8656. Email: [email protected].
Get access Rights & Permissions [Opens in a new window]

Abstract

Background: The Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) offers information on the clinical diagnosis of Alzheimer's disease (AD) and gives a profile of cognitive functioning. This study explores the effects of age, education and gender on participants' performance on eight subtests in the Chinese-Cantonese version of the CERAD-NAB.

Methods: The original English version of the CERAD-NAB was translated and content-validated into a Chinese-Cantonese version to suit the Hong Kong Chinese population. The battery was administered to 187 healthy volunteers aged 60 to 94 years. Participants were excluded if they had neurological, medical or psychiatric disorders (including dementia). Stepwise multiple linear regression analyses were performed to assess the relative contribution of the demographic variables to the scores on each subtest.

Results: The Cantonese version of CERAD-NAB was shown to have good content validity and excellent inter-rater reliability. Stepwise multiple regression analyses revealed that performances on seven and four out of eight subtests in the CERAD-NAB were significantly influenced by education level and age, respectively. Age and education had significant effects on participants' performance on many tests. Gender also showed a significant effect on one subtest.

Conclusions: The preliminary data will serve as an initial phase for clinical interpretation of the CERAD-NAB for Cantonese-speaking Chinese elders.

Keywords

cognitive profilevalidationAlzheimer's diseaseChinese elders
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 10 , December 2011 , pp. 1575 - 1581
Copyright
Copyright © International Psychogeriatric Association 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chiu, F. K. et al. (1998). Prevalence of dementia in Chinese elderly in Hong Kong. Neurology, 50, 1002–1009.CrossRefGoogle ScholarPubMed
Ganguli, M. et al. (1991). Effects of age, gender, and education on cognitive tests in a rural elderly community sample: norms from the Monongahela Valley Independent Elders survey. Neuroepidemiology, 10, 42–52.CrossRefGoogle Scholar
Lee, D. Y. et al. (2004). A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. Journal of the International Neuropsychological Society, 10, 72–81.CrossRefGoogle ScholarPubMed
Morris, J. C. et al. (1993). Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Part IV. Rates of cognitive change, a longitudinal assessment of probable Alzheimer's disease. Neurology, 43, 2457–2465.CrossRefGoogle Scholar
Morris, J. C., Mohs, R. C., Rogers, H., Fillenbaum, G. and Heyman, A. (1988). CERAD: clinical and neuropsychological assessment of Alzheimer's disease. Psychopharmacology Bulletin, 4, 641–652.Google Scholar
People's Daily Online (2006). China's elderly population reaches 143 million. China. Available at www.people.com.cn.Google Scholar
Sosa, A. L. et al. (2009). Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey. BMC Neurology, 9, 48.CrossRefGoogle Scholar
Stewart, R., Richards, M., Brayne, C. and Mann, A. (2001). Cognitive function in UK community dwelling African Caribbean elders: normative data for a test battery. International Journal of Geriatric Psychiatry, 16, 518–527.CrossRefGoogle ScholarPubMed
US Department Of Health And Human Services (1996). Early Alzheimer's Disease: Recognition and Assessment. AHCPR Publication No 97 – R123. Washington, DC: US Agency for Health Care Policy and Research.Google Scholar
Welsh-Bohmer, K. A. and Mohs, R. C. (1997). Neuropsychological assessment of Alzheimer's disease. Neurology, 49, S11–S13.CrossRefGoogle ScholarPubMed
Welsh, K., Butters, N., Hughes, J. P., Mohs, R. and Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Archives of Neurology, 48, 278–281.CrossRefGoogle ScholarPubMed
Welsh, K. et al. (1994). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V: A normative study of the neuropsychological battery. Neurology, 44, 609–614.CrossRefGoogle Scholar