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Dopaminergic imaging: clinical utility now and in the future

Published online by Cambridge University Press:  15 August 2011

Zuzana Walker  and
Joanne Rodda
Zuzana Walker*
Affiliation:
University College London and North Essex Partnership NHS Foundation Trust, Mental Health Unit, St Margaret's Hospital, Epping, Essex, UK
Joanne Rodda
Affiliation:
Research Department of Mental Health Sciences, University College London, London, UK
*
Correspondence should be addressed to: Zuzana Walker, MD, FRCPsych, University College London and North Essex Partnership NHS Foundation Trust, Mental Health Unit, St Margaret's Hospital, The Plain, Epping, Essex, CM16 6TN, UK. Phone: +44 1279-827-893; Fax: +44 1992-571-089. Email: [email protected].
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Abstract

Over the past ten years, dopaminergic imaging has become increasingly part of the assessment and diagnosis of dementia. There are numerous PET and SPECT ligands available that target different steps in the process of neurotransmission. Abnormalities in dopaminergic imaging measures are consistent features of dementia with Lewy bodies (DLB) and other parkinsonian syndromes, and can be used to facilitate diagnosis, particularly in distinguishing between DLB and Alzheimer's disease. This review summarizes present knowledge in this area and the implications for current and future clinical practice.

Keywords

dopaminergic imagingdementia with Lewy bodiesparkinsonian syndromes[123I] FP-CIT-SPECT[18F]DOPA- PET[11C]DTBZ- PET
Type
Review Article
Information
International Psychogeriatrics , Volume 23 , Supplement S2: Clinical use of neuroimaging in dementia: an international perspective , September 2011 , pp. S32 - S40
Copyright
Copyright © International Psychogeriatric Association 2011

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