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Differentiating illiteracy from Alzheimer's disease by using neuropsychological assessments

Published online by Cambridge University Press:  22 July 2011

Jung-Hae Youn ,
Maryse Siksou ,
R. Scott Mackin ,
Jung-Seok Choi ,
Jeanyung Chey  and
Jun-Young Lee
Jung-Hae Youn
Affiliation:
Department of Psychiatry, Seoul National University Boramae Hospital, Seoul, Korea
Maryse Siksou
Affiliation:
Department of Psychology, University of Paris – Paris 7, Paris, France
R. Scott Mackin
Affiliation:
Department of Psychiatry, University of California, San Francisco, California, USA
Jung-Seok Choi
Affiliation:
Department of Psychiatry, Seoul National University Boramae Hospital, Seoul, Korea
Jeanyung Chey
Affiliation:
Department of Psychology, Seoul National University, Seoul, Korea
Jun-Young Lee*
Affiliation:
Department of Psychiatry, Seoul National University Boramae Hospital, Seoul, Korea
*
Correspondence should be addressed to: JY Lee, Department of Psychiatry, Seoul National University Boramae Hospital, 395 Sindaebang-2-dong, Dongjak-ku, Seoul 156-707, Korea. Phone: +82-2870-2462; Fax: +82-2870-3866. Email: [email protected].
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Abstract

Background: In Asia, where illiteracy rates are high, determining the degree to which neuropsychological measures can be used to identify cognitive impairment in illiterate elders is important. The aim of this study was to evaluate the effectiveness of using formal neuropsychological assessments to distinguish healthy illiterate elders from dementia patients.

Methods: We compared the cognitive performance of healthy elders who were illiterate (illiterate NC, n = 25) with those who were literate (literate NC, n = 25), literate patients with mild Alzheimer's disease (literate AD, n = 25), and illiterate patients with mild AD (illiterate AD, n = 25). Neuropsychological measures included the Mini-Mental State Examination (MMSE), the verbal fluency test, the Boston naming test, the Rosen drawing test, and the verbal learning test.

Results: In the between-group analyses, the scores on all tests, except verbal fluency and recognition memory, were lower for illiterate NC compared to the literate NC. The scores on the MMSE, Boston naming test, Rosen drawing test, and immediate free recall could not distinguish the illiterate NC from literate AD. However, the scores on all tests, except the Rosen drawing test, could distinguish illiterate NC from illiterate AD. ROC analyses showed the same pattern of results. In addition, age-, sex-, and education-matched cut-off scores of all tests, except immediate recall and delayed recall trials of the verbal learning test, showed good specificities in participants who were illiterate compared to those in participants who were literate.

Conclusion: These findings suggest that the impact of literacy on neuropsychological test performance is an important aspect of cognitive evaluations for elders who are illiterate.

Keywords

illiteracycognitionAlzheimer's diseaseneuropsychological testeducation
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 10 , December 2011 , pp. 1560 - 1568
Copyright
Copyright © International Psychogeriatric Association 2011

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