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Differential associations between depression and cognitive function in MCI and AD: a cross-sectional study

Published online by Cambridge University Press:  30 January 2019

Chang Hyun Lee ,
Do Hoon Kim  and
Yoo Sun Moon
Chang Hyun Lee
Affiliation:
Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea Mind-Neuromodulation Laboratory, Hallym University College of Medicine, Chuncheon, South Korea
Do Hoon Kim*
Affiliation:
Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea Mind-Neuromodulation Laboratory, Hallym University College of Medicine, Chuncheon, South Korea
Yoo Sun Moon
Affiliation:
Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea Institute for Skeletal Aging, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea
*
Correspondence should be addressed to: Do Hoon Kim, Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, 77 Sakju-ro, 24253 Chuncheon, Gangwon-Do, South Korea. Phone: +82-33-240-5277; Fax: +82-33-244-0317. Email: [email protected].
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Abstract

Objective:

Despite the possibility that cognitive deficits associated with depression may have different patterns depending on the level of neurocognitive impairment, there remains no clear evidence of this. This study aimed to investigate the differential association between depression and cognitive function in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).

Methods:

A cross-sectional analysis was performed of data from 1,724 patients with MCI and 1,247 patients with AD from the Clinical Research Center for Dementia in Korea. Depression was assessed using the Korean form of the Geriatric Depression Scale, and cognition was measured using the Seoul Neuropsychological Screening Battery, which includes five domains (attention, language and related function, visuospatial function, memory, and frontal/executive function).

Results:

Significant differences were found between the two groups (non-depressed vs. depressed) in visuospatial, memory, and executive function domains in the MCI group, as well as in the attention domain in the AD group. The association between depressive symptoms and cognitive function was significantly greater in patients with MCI than in those with AD. These associations were more pronounced in memory and executive function.

Conclusion:

Our findings suggest that the association between depression and decreased cognitive function is more pronounced in MCI than AD.

Keywords

Alzheimer’s diseasemild cognitive impairmentdepressioncognitive impairmentneuropathology
Type
Original Research Article
Information
International Psychogeriatrics , Volume 31 , Issue 8: Issue Theme: Dementia Care , August 2019 , pp. 1151 - 1158
Copyright
© International Psychogeriatric Association 2019 

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References

Berger, A. K., Fratiglioni, L., Winblad, B. and Bäckman, L. (2005). Alzheimer’s disease and depression: preclinical comorbidity effects on cognitive functioning. Cortex, 41, 1–8. doi: 10.1016/S0010-9452(08)70200-4.CrossRefGoogle ScholarPubMed
Brunet, J. et al. (2011). The relation between depressive symptoms and semantic memory in amnestic mild cognitive impairment and in late-life depression. Journal of the International Neuropsychological Society, 17, 865–874. doi: 10.1017/S1355617711000877.CrossRefGoogle ScholarPubMed
Cho, M. J. et al. (1999). Validation of geriatric depression scale, Korean version (GDS) in the assessment of DSM-III-R major depression. Journal of Korean Neuropsychiatric Association, 38, 48–63.Google Scholar
Choi, S. H. et al. (2001). Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale. Journal of the Korean Neurological Association, 19, 585–591.Google Scholar
Cipriani, G., Lucetti, C., Carlesi, C., Danti, S. and Nuti, A. (2015). Depression and dementia. A review. European Geriatric Medicine. 6, 479–486. doi: 10.1016/j.eurger.2015.07.010.CrossRefGoogle Scholar
Dong, H. S. et al. (2016). Characteristics of neurocognitive functions in mild cognitive impairment with depression. International Psychogeriatrics, 28, 1181–1190. doi: 10.1017/S1041610216000314.CrossRefGoogle ScholarPubMed
Geda, Y. E. et al. (2008). Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study. Archives of General Psychiatry, 65, 1193–1198. doi: 10.1001/archpsyc.65.10.1193.CrossRefGoogle ScholarPubMed
Geda, Y. E. et al. (2013). Neuropsychiatric symptoms in Alzheimer’s disease: past progress and anticipation of the future. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 9, 602–608. doi: 10.1016/j.jalz.2012.12.001.CrossRefGoogle Scholar
Hudon, C., Belleville, S. and Gauthier, S. (2008). The association between depressive and cognitive symptoms in amnestic mild cognitive impairment. International Psychogeriatrics, 20, 710–723. doi: 10.1017/S1041610208007114.CrossRefGoogle ScholarPubMed
Johnson, L. A. et al. (2013). Cognitive differences among depressed and non-depressed MCI participants: a Project FRONTIER study. International Journal of Geriatric Psychiatry, 28, 377–382. doi: 10.1002/gps.3835.CrossRefGoogle ScholarPubMed
Kang, Y., Na, D. L. and Hahn, S. (1997). A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. Journal of the Korean Neurological Association, 15, 300–308.Google Scholar
Kang, Y., Na, D. L. and Hahn, S. (2003). Seoul neuropsychological screening battery. Incheon: Human Brain Research & consulting co.Google Scholar
Kaup, A. R. et al. (2016). Trajectories of depressive symptoms in older adults and risk of dementia. JAMA Psychiatry, 73, 525–531. doi: 10.1001/jamapsychiatry.2016.0004.CrossRefGoogle Scholar
Lavretsky, H. et al. (2009). Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. American Journal of Geriatric Psychiatry, 17, 493–502. doi: 10.1097/JGP.0b013e3181953b82.CrossRefGoogle ScholarPubMed
Leong, C. (2014). Antidepressants for depression in patients with dementia: a review of the literature. The Consultant Pharmacist, 29, 254–263. doi: 10.4140/TCP.n.2014.254.CrossRefGoogle ScholarPubMed
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J. and DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 288, 1475–1483. doi: 10.1001/jama.288.12.1475.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939–939. doi: 10.1212/WNL.34.7.939.CrossRefGoogle ScholarPubMed
Mirza, S. S. et al. (2016). 10-year trajectories of depressive symptoms and risk of dementia: a population-based study. Lancet Psychiatry, 3, 628–635. doi: 10.1016/S2215-0366(16)00097-3.CrossRefGoogle ScholarPubMed
Modrego, P. J. and Ferrández, J. (2004). Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Archives of Neurology, 61, 1290–1293. doi: 10.1001/archneur.61.8.1290.CrossRefGoogle ScholarPubMed
Pink, A. et al. (2015). Neuropsychiatric symptoms, APOE ε4, and the risk of incident dementia: a population-based study. Neurology, 84, 935–943. doi: 10.1212/WNL.0000000000001307.CrossRefGoogle ScholarPubMed
Poletti, M., Nuti, A., Cipriani, G. and Bonuccelli, U. (2013). Behavioral and psychological symptoms of dementia: factor analysis and relationship with cognitive impairment. European Neurology, 69, 76–82. doi: 10.1159/000341956.CrossRefGoogle ScholarPubMed
Powlishta, K. K., Storandt, M., Mandernach, T. A., Hogan, E., Grant, E. A. and Morris, J. C. (2004). Absence of effect of depression on cognitive performance in early-stage Alzheimer disease. Archives of Neurology, 61, 1265–1268. doi: 10.1001/archneur.61.8.1265.CrossRefGoogle ScholarPubMed
Rapp, M. A. et al. (2011). Cognitive decline in patients with dementia as a function of depression. American Journal of Geriatric Psychiatry, 19, 357–363. doi: 10.1097/JGP.0b013e3181e898d0.CrossRefGoogle Scholar
Ravaglia, G. et al. (2008). Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort. American Journal of Geriatric Psychiatry, 16, 834–843. doi: 10.1097/JGP.0b013e318181f9b1.CrossRefGoogle Scholar
Sacuiu, S. et al. (2016). Chronic depressive symptomatology in mild cognitive impairment is associated with frontal atrophy rate which hastens conversion to Alzheimer dementia. American Journal of Geriatric Psychiatry, 24, 126–135. doi: 10.1016/j.jagp.2015.03.006.CrossRefGoogle ScholarPubMed
Shin, I. S., Carter, M., Masterman, D., Fairbanks, L. and Cummings, J. L. (2005). Neuropsychiatric symptoms and quality of life in Alzheimer disease. American Journal of Geriatric Psychiatry, 13, 469–474. doi: 10.1097/00019442-200506000-00005.CrossRefGoogle ScholarPubMed
Smith, G. E. et al. (1996). Definition, course, and outcome of mild cognitive impairment. Aging, Neuropsychology, and Cognition, 3, 141–147. doi: 10.1080/13825589608256619.CrossRefGoogle Scholar
Spalletta, G., Caltagirone, C., Girardi, P., Gianni, W., Casini, A. R. and Palmer, K. (2012). The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer’s disease patients. Psychiatry Research, 198, 263–268. doi: 10.1016/j.psychres.2011.11.018.CrossRefGoogle ScholarPubMed