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Cognitive Decline in Alzheimer's Disease: Elaborating on the Nature of the Longitudinal Factor Structure of the Mini-Mental State Examination

Published online by Cambridge University Press:  07 January 2005

John O. Brooks ,
Jerome A. Yesavage ,
Joy Taylor ,
Leah Friedman ,
Elizabeth Decker Tanke ,
Victoria Luby  and
Jared Tinklenberg
John O. Brooks
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Jerome A. Yesavage
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Joy Taylor
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Leah Friedman
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Elizabeth Decker Tanke
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Victoria Luby
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
Jared Tinklenberg
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, and the Veterans Administration Medical Center, Palo Alto, California, U.S.A.
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Abstract

The purpose of this paper was to use the Wechsler Adult Intelligence Scale (WAIS) to further define the nature of the underlying factors of the Mini-Mental State Examination (MMSE) as proposed by Tinklenberg et al. (1990). The MMSE was administered to 51 patients once every 6 months for at least one year; the WAIS was administered only at the beginning of the study. Stepwise regression analyses yielded these results: for the Following Commands factor, the best correlate was the Comprehension subtest; for the Language Repetition factor, the best correlate was the Picture Arrangement subtest; and for the Language Expression factor, the best correlates were the Digit Symbol and Object Assembly subtests. These relations help clarify the correlates of decline of AD patients on the MMSE.

Type
Research and Reviews
Information
International Psychogeriatrics , Volume 5 , Issue 2 , September 1993 , pp. 135 - 146
Copyright
© 1993 Springer Publishing Company

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