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Association between C-reactive protein and cognitive deficits in elderly men and women: a meta-analysis

Published online by Cambridge University Press:  04 January 2012

Dawson W. Hedges ,
Thomas J. Farrer  and
Bruce L. Brown
Dawson W. Hedges*
Affiliation:
Department of Psychology, Brigham Young University, Provo, Utah, USA The Neuroscience Center, Brigham Young University, Provo, Utah, USA
Thomas J. Farrer
Affiliation:
Department of Psychology, Brigham Young University, Provo, Utah, USA
Bruce L. Brown
Affiliation:
Department of Psychology, Brigham Young University, Provo, Utah, USA
*
Correspondence should be addressed to: Dawson W. Hedges, MD, Department of Psychology, Brigham Young University, Provo, Utah 84602, USA. Phone: +801-422-6357. Email: [email protected].
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Abstract

Background: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.

Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.

Results: While we identified no studies containing only male subjects, the two identified studies containing both female and male subjects (n = 2,525) showed an effect size for cognition of −0.1809 (95% confidence interval, −0.2652 to −0.0967, p = 0.000025) between high and low C-reactive-protein groups. In contrast, the two identified studies containing only female subjects (n = 1,754) showed an effect size for cognition of 0.0345 (95% confidence interval, −0.0594 to 0.1285, not significant).

Conclusions: In the context of a small number of source studies and lack of an all-male group, these results suggest that any association between C-reactive protein and cognitive deficits may be stronger in elderly men than in elderly women.

Keywords

C-reactive proteincognitioncognitive deficitsgenderMini-Mental State Examination
Type
Review Article
Information
International Psychogeriatrics , Volume 24 , Issue 9 , September 2012 , pp. 1387 - 1392
Copyright
Copyright © International Psychogeriatric Association 2012

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References

Aartsen, M. J., Martin, M., Zimprich, D. and the Longitudinal Aging Study Amsterdam (2004). Gender differences in level and change in cognitive functioning: results from the Longitudinal Aging Study Amsterdam. Gerontology, 50, 35–38.CrossRefGoogle ScholarPubMed
Aiello, A. E., Haan, M., Blythe, L., Moore, K., Gonzalez, J. M. and Jagust, W. (2006). The influence of latent viral infection on rate of cognitive decline over 4 years. Journal of the American Geriatrics Society, 54, 1046–1054.CrossRefGoogle ScholarPubMed
Alley, D. E., Crimmins, E. M., Karlamangla, A., Hu, P. and Seeman, T. E. (2008). Inflammation and rate of cognitive change in high-functioning older adults. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 63, 50–55.CrossRefGoogle ScholarPubMed
Anderson, V. A., Anderson, P., Northam, E., Jacobs, R. and Catroppa, C. (2001). Development of executive functions through late childhood and adolescence in an Australian sample. Developmental Neuropsychology, 20, 385–406.CrossRefGoogle Scholar
Borenstein, M., Hedges, L. V., Higgins, J. P. T. and Rothstein, H. R. (2009). Introduction to Meta-Analysis. Chichester: John Wiley & Sons, Ltd.CrossRefGoogle Scholar
Clark, C. R. et al. (2006). Standardized assessment of cognitive functioning during development and aging using an automated touchscreen battery. Archives of Clinical Neuropsychology, 21, 449–467.CrossRefGoogle ScholarPubMed
Compton, D. M., Avet-Compton, T., Bachman, L. D. and Brand, D. (2003). Working memory and perceptual speed mediation of age-associated changes in cognition within a sample of highly-educated adults. North American Journal of Psychology, 5, 451–477.Google Scholar
Dickerson, F., Stallings, C., Origoni, A., Boronow, J. and Yolken, R. (2007). C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophrenia Research, 93, 261–265.CrossRefGoogle Scholar
Dik, M. G., Jonker, C., Hack, C. E., Smit, J. H., Comijs, H. C. and Eikelenboom, P. (2005). Serum inflammatory proteins and cognitive decline in older persons. Neurology, 64, 1371–1377.CrossRefGoogle ScholarPubMed
Dziedzic, T. (2006). Systemic inflammatory markers and risk of dementia. American Journal of Alzheimer's Disease and Other Dementias, 21, 258–262.CrossRefGoogle ScholarPubMed
Finkel, D., Reynolds, C. A., Berg, S. and Pedersen, N. L. (2006). Surprising lack of sex differences in normal cognitive aging in twins. International Journal of Aging & Human Development, 62, 335–357.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state:” a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle ScholarPubMed
Guilmette, T. J. and Rasile, D. (1995). Sensitivity, specificity, and diagnostic accuracy of three verbal memory measures in the assessment of mild brain injury. Neuropsychology, 9, 338–344.CrossRefGoogle Scholar
Hedges, L. V. and Olkin, I. (1985). Statistical Methods for Meta-Analysis. Orlando, FL: Academic Press.Google Scholar
Ho, K. M. and Lipman, J. (2009). An update on C-reactive protein for intensivists. Anaesthesia and Intensive Care, 37, 234–241.CrossRefGoogle ScholarPubMed
Komulainen, P. et al. (2007). Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age and Ageing, 36, 443–448.CrossRefGoogle ScholarPubMed
Kukull, W. A. (2006). The growing global burden of dementia. Lancet Neurology, 5, 199–200.CrossRefGoogle ScholarPubMed
Kuo, H. K., Yen, C. J., Chang, C. H., Kuo, C. K., Chen, J. H. and Sorond, F. (2005). Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurology, 4, 371–380.CrossRefGoogle ScholarPubMed
Nieuwenhuis-Mark, R. E. (2010). The death knoll for the MMSE: has it outlived its purpose? Journal of Geriatric Psychiatry and Neurology, 23, 151–157.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. (2010). Prevalence of mild cognitive impairment is higher in men. the Mayo Clinic Study of Aging. Neurology, 75, 889–897.CrossRefGoogle ScholarPubMed
Teunissen, C. E. et al. (2003). Inflammation markers in relation to cognition in a healthy aging population. Journal of Neuroimmunology, 134, 142–150.CrossRefGoogle Scholar
Tilvis, R. S., Kahonen-Vare, M. H., Jolkkonen, J., Valvanne, J., Pitkala, K. H. and Strandberg, T. E. (2004). Predictors of cognitive decline and mortality of aged people over a 10-year period. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 59, 268–274.CrossRefGoogle ScholarPubMed
van Hooren, S. A., Valentijn, A. M., Bosma, H., Ponds, R. W., van Boxtel, M. P. and Jolles, J. (2007). Cognitive functioning in healthy older adults aged 64–81: a cohort study into the effects of age, sex, and education. Neuropsychology, Development, and Cognition Section B, Aging, Neuropsychology, and Cognition, 14, 40–54.CrossRefGoogle ScholarPubMed
Wassel, C. L., Barrett-Connor, E. and Laughlin, G. A. (2010). Association of circulating C-reactive protein and interleukin-6 with longevity into the 80s and 90s: The Rancho Bernardo Study. The Journal of Clinical Endocrinology and Metabolism, 95, 4748–4755.CrossRefGoogle ScholarPubMed
Weuve, J., Ridker, P. M., Cook, N. R., Buring, J. E. and Grodstein, F. (2006). High-sensitivity C-reactive protein and cognitive function in older women. Epidemiology, 17, 183–189.CrossRefGoogle ScholarPubMed
Whitehead, A. (2002). Meta-Analysis of Controlled Clinical Trials. Chichester: John Wiley & Sons.CrossRefGoogle Scholar
Yaffe, K. et al. (2003). Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology, 61, 76–80.CrossRefGoogle ScholarPubMed