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Apathy and depression as risk factors for dementia conversion in mild cognitive impairment

Commentary on “Apathy and Depression in Mild Cognitive Impairment: Distinct Longitudinal Trajectories and Clinical Outcomes” by Connors et al.

Published online by Cambridge University Press:  30 January 2023

Latha Velayudhan
Latha Velayudhan*
Affiliation:
Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom South London and Maudsley NHS Foundation Trust, London, United Kingdom Department of Population Health Sciences, University of Leicester, Leicester, United Kingdom
*
Email: [email protected]
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Type
Commentary
Information
International Psychogeriatrics , Volume 35 , Special Issue 11: Issue Theme: Neuropsychiatric Symptoms of Mild and Major Neurocognitive Disorders , November 2023 , pp. 598 - 600
Copyright
© International Psychogeriatric Association 2023

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References

Connors, M., Teixeira-Pinto, A., Ames, D., Woodward, M. and Brodaty, H. (2023). Apathy and depression in mild cognitive impairment: distinct longitudinal trajectories and clinical outcomes. International Pyschogeriatrics. https://doi.org/10.1017/S1041610222001089CrossRefGoogle ScholarPubMed
Fan, Z., et al. (2021). Apathy as a risky neuropsychiatric syndrome of progression from normal aging to mild cognitive impairment and dementia: a systematic review and meta-analysis. Frontiers in Psychiatry, 12, 792168.10.3389/fpsyt.2021.792168CrossRefGoogle ScholarPubMed
Fang, F., Gao, Y., Schulz, P. E., Selvaraj, S. and Zhang, Y. (2021). Brain controllability distinctiveness between depression and cognitive impairment. Journal of Affective Disorders, 294, 847–856.10.1016/j.jad.2021.07.106CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.10.1016/0022-3956(75)90026-6CrossRefGoogle ScholarPubMed
Karameh, W. K., et al. (2022). Comparing cardiovascular risk factors in older persons with mild cognitive impairment and lifetime history of major depressive disorder. International Psychogeriatrics, 34, 563–569.10.1017/S1041610221000259CrossRefGoogle ScholarPubMed
Kim, S., et al. (2016). Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct. International Journal of Geriatric Psychiatry, 31, 818–826.10.1002/gps.4400CrossRefGoogle ScholarPubMed
Kraynak, T. E. and Andreescu, C. (2022). Pathways linking hypertension and depression with mild cognitive impairment in older adults. International Psychogeriatrics, 34, 515–517.10.1017/S1041610222000278CrossRefGoogle ScholarPubMed
Lee, C. H., Kim, D. H. and Moon, Y. S. (2019). Differential associations between depression and cognitive function in MCI and AD: a cross-sectional study. International Psychogeriatrics, 31, 1151–1158.10.1017/S1041610218001527CrossRefGoogle Scholar
Martin, E. and Velayudhan, L. (2020). Neuropsychiatric symptoms in mild cognitive impairment: a literature review. Dementia and Geriatric Cognitive Disorders, 49, 146–155.10.1159/000507078CrossRefGoogle ScholarPubMed
Monastero, R., Mangialasche, F., Camarda, C., Ercolani, S. and Camarda, R. (2009). A systematic review of neuropsychiatric symptoms in mild cognitive impairment. Journal of Alzheimers Disease, 18, 11–30.10.3233/JAD-2009-1120CrossRefGoogle ScholarPubMed
Mortby, M. E., et al. (2022). Apathy as a treatment target in Alzheimer’s disease: implications for clinical trials. The American Journal of Geriatric Psychiatry, 30, 119–147.10.1016/j.jagp.2021.06.016CrossRefGoogle ScholarPubMed
Palmer, K., et al. (2010). Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer’s disease: the role of depression and apathy. Journal of Alzheimers Disease, 20, 175–183.10.3233/JAD-2010-1352CrossRefGoogle ScholarPubMed
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194.10.1111/j.1365-2796.2004.01388.xCrossRefGoogle ScholarPubMed
Richard, E., et al. (2012). Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer’s disease in non-depressed subjects. Dementia and Geriatric Cognitive Disorders, 33, 204–209.10.1159/000338239CrossRefGoogle ScholarPubMed
Ruthirakuhan, M., Herrmann, N., Vieira, D., Gallagher, D. and Lanctôt, K. L. (2019). The roles of apathy and depression in predicting Alzheimer disease: a longitudinal analysis in older adults with mild cognitive impairment. American Journal of Geriatric Psychiatry, 27, 873–882.10.1016/j.jagp.2019.02.003CrossRefGoogle ScholarPubMed
Siafarikas, N., et al. (2021). Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer’s disease with dementia. International Psychogeriatrics, 33, 1217–1228.10.1017/S1041610221000934CrossRefGoogle ScholarPubMed
Starkstein, S. E., Mizrahi, R., Capizzano, A. A., Acion, L., Brockman, S. and Power, B. D. (2009). Neuroimaging correlates of apathy and depression in Alzheimer’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 21, 259–265.10.1176/jnp.2009.21.3.259CrossRefGoogle ScholarPubMed
Vicini Chilovi, B., Conti, M., Zanetti, M., Mazzù, I., Rozzini, L. and Padovani, A. (2009). Differential impact of apathy and depression in the development of dementia in mild cognitive impairment patients. Dementia and Geriatric Cognitive Disorders, 27, 390–398.10.1159/000210045CrossRefGoogle ScholarPubMed
Wong, B., Ismail, Z. and Goodarzi, Z. (2022). Detecting depression in persons living with mild cognitive impairment: a systematic review. International Psychogeriatrics, 34, 453–465.10.1017/S1041610222000175CrossRefGoogle ScholarPubMed
Zacková, L., Jáni, M., Brázdil, M., Nikolova, Y. S. and Marečková, K. (2021). Cognitive impairment and depression: meta-analysis of structural magnetic resonance imaging studies. NeuroImage: Clinical, 32, 102830.10.1016/j.nicl.2021.102830CrossRefGoogle ScholarPubMed