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An international perspective on advanced neuroimaging: cometh the hour or ivory tower?

Published online by Cambridge University Press:  15 August 2011

Craig W. Ritchie ,
David Ames ,
James R. Burke ,
Julian Bustin ,
Peter Connelly ,
Jan Laczo  and
Florence Portet
Craig W. Ritchie*
Affiliation:
Centre for Mental Health, Imperial College London, UK
David Ames
Affiliation:
National Ageing Research Unit, Melbourne, Victoria, Australia
James R. Burke
Affiliation:
Memory Disorders Clinic, Duke University Medical Center, Durham, North Carolina, USA
Julian Bustin
Affiliation:
Geriatric Psychiatry, INECO and Neurosciences Institute of the Favaloro Foundation, Buenos, Aires, Argentina
Peter Connelly
Affiliation:
Murray Royal Hospital, Perth, Scotland, UK
Jan Laczo
Affiliation:
Department of Neurology, Charles University, 2nd Medical School, Prague, Czech Republic
Florence Portet
Affiliation:
Neurology B Department, CHU Gui de Chauliac, Montpellier, France
*
Correspondence should be addressed to: Dr. Craig W Ritchie, Centre for Mental Health, Imperial College London, Claybrook Centre, 37 Claybrook Road, Hammersmith, London, UK. Phone: +44 (0) 20 7386 1233; Fax: +44 (0) 20 7386 1216. Email: [email protected]
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Abstract

Over the past five to ten years, neuroimaging capability for neurodegenerative diseases has made remarkable progress. However, debate remains as to the true clinical utility of these advanced and costly investigations. Not only is the place of these tests in diagnostic algorithms unclear, but the access to them varies both within and between countries. We sought to gather informed opinion from recognized leaders in the field who can combine both an academic and a clinical perspective on the use of neuroimaging in their own countries. Opinion is presented from Scotland, Argentina, the Czech Republic, France, the USA and Australia. The emerging consensus was one of ongoing caution. While in most countries there was a sense that the use of more advanced imaging techniques was growing, their hour has not yet cometh. However, these techniques, rather than falling from the Ivory Tower, should descend slowly step by step onto fertile and receptive clinics from where better clinical guidelines will emerge.

Keywords

dementianeuroimagingdiagnosismagnetic resonance imagingPET scanamyloidAlzheimer's disease
Type
Review Article
Information
International Psychogeriatrics , Volume 23 , Supplement S2: Clinical use of neuroimaging in dementia: an international perspective , September 2011 , pp. S58 - S64
Copyright
Copyright © International Psychogeriatric Association 2011

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References

Bartoš, A., Píchová, R., Trojanová, H., Lang, O. and Řípová, D. (2008). Brain SPECT in the diagnosis of Alzheimer's disease. Psychiatrie, 12 (Suppl. 3), 8–11.Google Scholar
Cano, S. J. et al. (2010). The ADAS-Cog in Alzheimer's disease clinical trials: psychometric evaluation of the sum and its parts. Journal of Neurology, Neurosurgery and Psychiatry, 81, 1363–1368.CrossRefGoogle ScholarPubMed
Chupin, M. et al. (2007). Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: method and validation on controls and patients with Alzheimer's disease. Neuroimage, 34, 996–1019.CrossRefGoogle ScholarPubMed
Dubois, B. et al. (2010). Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurology, 9, 1118–1127.CrossRefGoogle ScholarPubMed
Ellis, K. et al. (2009). The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21, 672–687.CrossRefGoogle ScholarPubMed
Foy, J. (2008). A survey of memory clinic practice in Scotland. Psychiatric Bulletin, 32, 467–469.CrossRefGoogle Scholar
Holmerová, I. (2007). Supporting Family Carers of Older People in Europe: The National Background Report for the Czech Republic. LIT Verlag: Münster Westf.Google Scholar
Iglehart, J. K. (2009). Health insurers and medical-imaging policy: a work in progress. New England Journal of Medicine, 360, 1030–1037CrossRefGoogle ScholarPubMed
Jack, C. R. et al. for the Alzheimer's Disease Neuroimaging Initiative (2009). Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain, 132, 1355–1365.CrossRefGoogle ScholarPubMed
Kalaria, R. N. et al. (2008). Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurology, 7, 812–826.CrossRefGoogle ScholarPubMed
Matthews, F. E., Stephan, B. C., McKeith, I. G., Bond, J. and Brayne, C. for the Medical Research Council Cognitive Function and Ageing Study (2008). Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree? Journal of the American Geriatric Society, 56, 1424–1433.CrossRefGoogle ScholarPubMed
McKeith, I. et al. for the DLB Study Group (2007). Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurology, 6, 305–313.CrossRefGoogle ScholarPubMed
National Center for Health Statistics (2010). Health, United States, 2009: With Special Feature on Medical Technology. Hyattsville, MD: National Center for Health Statistics.Google Scholar
Nobili, F. et al. (2008). Brain SPECT in subtypes of mild cognitive impairment: findings from the DESCRIPA multicenter study. Journal of Neurology, 255, 1344–5133.CrossRefGoogle ScholarPubMed
Ott, A. et al. (1995). Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam Study. BMJ, 310, 970.CrossRefGoogle ScholarPubMed
Pages Larraya, F., Grasso, L. and Mari, G. (2004). Prevalence of dementia of the Alzheimer type, vascular dementia and other DSM-IV and ICD-10 dementias in Republica Argentina. Revista Neurologica Argentina, 29, 144–153.Google Scholar
Pelosi, A. J., McNulty, S. V. and Jackson, G. A. (2006). Role of cholinesterase inhibitors in dementia care needs rethinking. BMJ, 333 491–493.CrossRefGoogle ScholarPubMed
Plassman, B. L. et al. (2008). Prevalence of cognitive impairment without dementia in the United States. Annals of Internal Medicine, 148, 427–434.CrossRefGoogle ScholarPubMed
Ritchie, K. et al. (2010). Caffeine, cognitive functioning, and white matter lesions in the elderly: establishing causality from epidemiological evidence. Journal of Alzheimer's Disease, 20 (Suppl. 1), S161–166.CrossRefGoogle ScholarPubMed
Stephan, B. C. M., Savva, G. M., Brayne, C., Bond, J. B. A., McKeith, I. G. and Matthews, F. E. for the Medical Research Council Cognitive Function and Ageing Study (2010). Optimizing mild cognitive impairment for discriminating dementia risk in the general older population. American Journal of Geriatric Psychiatry, 18, 662–673.CrossRefGoogle ScholarPubMed
van de Pol, L. A. et al. (2009). White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study. Journal of Neurology, Neurosurgery and Psychiatry, 80, 1069–1074.CrossRefGoogle ScholarPubMed
Villain, N. et al. (2010). Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease. Brain, 133, 3301–3314.CrossRefGoogle ScholarPubMed