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Semantic clustering and sleep in patients with amnestic mild cognitive impairment or with vascular cognitive impairment-no dementia

Published online by Cambridge University Press:  12 May 2016

Qingna Sun ,
Lanlan Luo ,
Honglei Ren ,
Changjuan Wei ,
Mengya Xing ,
Yan Cheng  and
Nan Zhang
Qingna Sun
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Lanlan Luo
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Honglei Ren
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Changjuan Wei
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Mengya Xing
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Yan Cheng
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Nan Zhang*
Affiliation:
Department of Neurology, Key Laboratory of Post-traumatic Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
*
Correspondence should be addressed to: Nan Zhang, MD, PhD, Department of Neurology, Tianjin Medical University General Hospital, 154, Anshan Road, Tianjin 300052, China. Phone: +8622 60814622; Fax: +8622 60817471. Email: [email protected].
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Abstract

Background:

Cognition and sleep deficits occur in amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment-no dementia (VCIND). However, how memory and sleep deficits differ between aMCI and VCIND remains unclear.

Methods:

Fifty aMCI and 50 VCIND patients and 38 sex- and age-matched healthy controls (HCs) were administered the Hopkins Verbal Learning Test-Revised (HVLT-R), Trail Making Test-A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Benton Judgment of Line Orientation (JLO) test, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Insomnia Severity Index (ISI) to quantify cognitive deficits and subjective sleep disturbance.

Results:

Compared with VCIND patients, aMCI patients had lower HVLT-R scores for total recall (p < 0.001), delayed recall (p < 0.001) and recognition (p = 0.001), and for total-recall (p = 0.002) and delayed-recall (p < 0.001) semantic clustering ratios (SCRs). However, VCIND patients exhibited more obvious executive dysfunction (TMT-A, p < 0.001; TMT-B, p < 0.001; WCST, p < 0.001), lower information processing speed (PASAT, p = 0.003; SDMT, p < 0.001), and more severe sleep disturbance (PSQI, p < 0.001; ESS, p < 0.001; ISI, p < 0.001). Additionally, sleep quality and efficiency were related to total and delayed recall (all r values from −0.31 to −0.60, p < 0.05) in aMCI and VCIND.

Conclusions:

aMCI and VCIND differ in cognitive function, memory strategy and sleep impairment; these characteristics are helpful to identify and distinguish patients with very early cognitive impairment. Our results also suggest that memory deficits are associated with sleep disturbance in aMCI and VCIND.

Keywords

amnestic mild cognitive impairmentvascular cognitive impairment-no dementiamemorysemantic clusteringsleep
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 9 , September 2016 , pp. 1493 - 1502
Copyright
Copyright © International Psychogeriatric Association 2016 

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