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Risk of progression from mild memory impairment to clinically diagnosable Alzheimer's disease in a Japanese community (from the Nakayama Study)

Published online by Cambridge University Press:  16 December 2010

Naomi Sonobe ,
Ryuji Hata ,
Tomohisa Ishikawa ,
Kantaro Sonobe ,
Teruhisa Matsumoto ,
Yasutaka Toyota ,
Takaaki Mori ,
Ryuji Fukuhara ,
Kenjiro Komori  and
Shu-ichi Ueno
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Naomi Sonobe
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Ryuji Hata*
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan Department of Functional Histology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Tomohisa Ishikawa
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Kantaro Sonobe
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Teruhisa Matsumoto
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Yasutaka Toyota
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Takaaki Mori
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Ryuji Fukuhara
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Kenjiro Komori
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Shu-ichi Ueno
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Satoshi Tanimukai
Affiliation:
Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
Manabu Ikeda
Affiliation:
Department of Psychiatry and Neuropathobiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
*
Correspondence should be addressed to: Ryuji Hata, MD, PhD, Department of Functional Histology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. Phone: + 81 89960 5236; Fax: + 81 89960 5239. Email: [email protected].
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Abstract

Background: Memory impairment has been proposed as the most common early sign of Alzheimer's disease (AD). The aims of this work were to evaluate the risk of progression from mild memory impairment/no dementia (MMI/ND) to clinically diagnosable AD in a community-based prospective cohort and to establish the risk factors for progression from MMI/ND to AD in the elderly.

Methods: Elderly subjects aged over 65 years were selected from the participants in the first Nakayama study. MMI/ND was defined as memory deficit on objective memory assessment, without dementia, impairment of general cognitive function, or disability in activities of daily living. A total of 104 MMI/ND subjects selected from 1242 community-dwellers were followed longitudinally for five years.

Results: During the five-year follow-up, 11 (10.6%) subjects were diagnosed with AD, five (4.8%) with vascular dementia (VaD), and six (5.8%) with dementia of other etiology. Logistic regression analysis revealed that diabetes mellitus (DM) and a family history of dementia (within third-degree relatives) were positively associated with progression to AD, while no factor was significantly associated with progression to VaD or all types of dementia.

Conclusions: DM and a family history of dementia were significant risk factors for progression from MMI/ND to clinically diagnosable AD in the elderly in a Japanese community.

Keywords

dementiavascular dementiamild cognitive impairment
Type
Research Article
Information
International Psychogeriatrics , Volume 23 , Issue 5 , June 2011 , pp. 772 - 779
Copyright
Copyright © International Psychogeriatric Association 2010

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References

Ahtiluoto, S. et al. (2010). Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology, 75, 1195–1202.Google Scholar
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. Washington, DC: American Psychiatric Association.Google Scholar
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A. and Bennett, D. A. (2004). Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Archives of Neurology, 61, 661–666.CrossRefGoogle ScholarPubMed
Bendlin, B. B. et al. (2010). Midlife predictors of Alzheimer's disease. Maturitas, 65, 131–137.Google Scholar
Biessels, G. J., De Leeuw, F. E., Lindeboom, J., Barkhof, F. and Scheltens, P. (2006). Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus. Journal of Neurology, Neurosurgery and Psychiatry, 77, 304–307.CrossRefGoogle ScholarPubMed
Burns, A. and O'Brien, J. (2006). Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology. Journal of Psychopharmacology, 20, 732–755.CrossRefGoogle ScholarPubMed
Chen, J. H., Lin, K. P. and Chen, Y. C. (2009). Risk factors for dementia. Journal of the Formosan Medical Association, 108, 754–764.CrossRefGoogle ScholarPubMed
Farias, S. T., Mungas, D., Reed, B. R., Harvey, D. and DeCarli, C. (2009). Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts. Archives of Neurology, 66, 1151–1157.Google Scholar
Gasparini, L. and Xu, H. (2003). Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences, 26, 404–406.CrossRefGoogle ScholarPubMed
Gatz, M. et al. (2005). Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study. Neurobiology of Aging, 26, 439–447.Google Scholar
Gauthier, S. et al. (2006). Mild cognitive impairment. The Lancet, 367, 1262–1270.CrossRefGoogle ScholarPubMed
Heun, R., Kolsch, H. and Jessen, F. (2006). Risk factors and early signs of Alzheimer's disease in a family study sample: risk of AD. European Archives of Psychiatry and Clinical Neuroscience, 256, 28–36.CrossRefGoogle Scholar
Hulette, C. M., Welsh-Bohmer, K. A., Murray, M. G., Saunders, A. M., Mash, D. C. and McIntyre, L. M. (1998). Neuropathological and neuropsychological changes in “normal” aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. Journal of Neuropathology and Experimental Neurology, 57, 1168–1174.Google Scholar
Ikeda, M. et al. (2001). Increased prevalence of vascular dementia in Japan: a community-based epidemiological study. Neurology, 57, 839–844.Google Scholar
Ishikawa, T., Ikeda, M., Matsumoto, N., Shigenobu, K., Brayne, C. and Tanabe, H. (2006). A longitudinal study regarding conversion from mild memory impairment to dementia in a Japanese community. International Journal of Geriatric Psychiatry, 21, 134–139.Google Scholar
Kirshner, H. S. (2009). Vascular dementia: a review of recent evidence for prevention and treatment. Current Neurology and Neuroscience Reports, 9, 437–442.Google Scholar
Kodl, C. T. and Seaquist, E. R. (2008). Cognitive dysfunction and diabetes mellitus. Endocrine Reviews, 29, 494–511.CrossRefGoogle ScholarPubMed
Luck, T., Luppa, M., Briel, S. and Riedel-Heller, S. G. (2010). Incidence of mild cognitive impairment: a systematic review. Dementia and Geriatric Cognitive Disorders, 29, 164–175.Google Scholar
MacKnight, C., Rockwood, K., Awalt, E. and McDowell, I. (2002). Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dementia and Geriatric Cognitive Disorders, 14, 77–83.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.Google Scholar
Meyer, J. S., Xu, G., Thornby, J., Chowdhury, M. H. and Quach, M. (2002). Is mild cognitive impairment prodromal for vascular dementia like Alzheimer's disease? Stroke, 33, 1981–1985.Google Scholar
Mitchell, A. J. and Shiri-Feshki, M. (2009). Rate of progression of mild cognitive impairment to dementia: meta-analysis of 41 robust inception cohort studies. Acta Psychiatrica Scandinavica, 119, 252–265.Google Scholar
Mohs, R. C. et al. (2001). A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients. Neurology, 57, 481–488.Google Scholar
Mosconi, L. et al. (2010). Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's. Proceedings of the National Academy of Sciences of the United States of America, 107, 5949–5954.CrossRefGoogle ScholarPubMed
O'Brien, J. T. et al. (2003). Vascular cognitive impairment. The Lancet Neurology, 2, 89–98.Google Scholar
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194.CrossRefGoogle ScholarPubMed
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G. and Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303–308.Google Scholar
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L. and DeKosky, S. T. (2001). Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133–1142.CrossRefGoogle Scholar
Qiu, W. Q. and Folstein, M. F. (2006). Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiology of Aging, 27, 190–198.Google Scholar
Román, G. C. et al. (1993). Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–260.Google Scholar
Roriz-Filho, J. S. et al. (2009). (Pre)diabetes, brain aging, and cognition. Biochimica et Biophysica Acta, 5, 432–443.Google Scholar
Schneider, J. A., Aggarwal, N. T., Barnes, L., Boyle, P. and Bennett, D. A. (2009). The neuropathology of older persons with and without dementia from community versus clinic cohorts. Journal of Alzheimer's Disease, 18, 691–701.CrossRefGoogle ScholarPubMed
Stephan, B. C., Matthews, F. E., Khaw, K. T., Dufouil, C. and Brayne, C. (2009). Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimer's Research and Therapy, 1, 4.Google Scholar
Viswanathan, A., Rocca, W. A. and Tzourio, C. (2009). Vascular risk factors and dementia: how to move forward? Neurology, 72, 368–374.Google Scholar
Yesavage, J. A. (1988). Geriatric Depression Scale. Psychopharmacology Bulletin, 24, 709–711.Google ScholarPubMed