Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-01-24T01:50:46.907Z Has data issue: false hasContentIssue false
  • English
  • Français

Pattern of behavioral disturbances in corticobasal degeneration syndrome and progressive supranuclear palsy

Published online by Cambridge University Press:  27 March 2009

Barbara Borroni ,
Antonella Alberici ,
Chiara Agosti ,
Maura Cosseddu  and
Alessandro Padovani
Barbara Borroni*
Affiliation:
Department of Neurology, University of Brescia, Italy
Antonella Alberici
Affiliation:
Department of Neurology, University of Brescia, Italy
Chiara Agosti
Affiliation:
Department of Neurology, University of Brescia, Italy
Maura Cosseddu
Affiliation:
Department of Neurology, University of Brescia, Italy
Alessandro Padovani
Affiliation:
Department of Neurology, University of Brescia, Italy
*
Correspondence should be addressed to: Barbara Borroni, M.D., Clinica Neurologica, Università degli Studi di Brescia, Pza Spedali Civili, 1 – 25100 Brescia, Italy. Phone +39 0303995632; Fax +39 0303995027. Email: [email protected].
Get access

Abstract

Background: A careful characterization of behavioral abnormalities in corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) by reliable tools is still lacking. Literature data provided evidence of the usefulness of the Frontal Behavioral Inventory (FBI) to operationalize such disturbances, particularly in the frontotemporal lobar degeneration spectrum. The study aimed to evaluate the frequency and pattern of presentation of behavioral disturbances in a large sample of CBDS and PSP patients by FBI.

Methods: Sixty-eight CBDS and 57 PSP patients entered the study and underwent a standardized clinical and neuropsychological battery, and a structural brain imaging study. Behavioral disturbances were carefully analyzed by FBI.

Results: FBI scores were relatively low in both groups, being 6.7 ± 8.2 and 5.6 ± 6.1 in CBDS and PSP, respectively. Comparison of the behavioral profile between CBDS and PSP patients showed significant differences in apathy were more frequent in the latter (57.9% vs. 33.8%, P = 0.007), and the presence of alien hand/apraxia more frequent in the former group 39.7% vs. 10.5%, P = 0.001). Apathy correlated neither with age nor with motor disturbances as measured by UPDRS-III. Overall, the most frequent behavioral abnormalities present in both groups (>25%) were aspontaneity and logopenia. Aphasia (27.9%) and irritability (35.3%) were more frequent in CBDS compared to PSP, even if not statistically different.

Discussion: The present study has provided measures of behavioral disturbances in a population of PSP and CBDS patients, and further confirms the usefulness of the FBI scale.

Keywords

behaviorcorticobasal degeneration syndromeprogressive supranuclear palsy
Type
Research Article
Information
International Psychogeriatrics , Volume 21 , Issue 3 , June 2009 , pp. 463 - 468
Copyright
Copyright © International Psychogeriatric Association 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aarsland, D., Litvan, I. and Larsen, J. P. (2001). Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 13, 42–49.CrossRefGoogle ScholarPubMed
Alberici, A. et al. (2007). The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease. Neurological Sciences, 28, 80–86.CrossRefGoogle ScholarPubMed
Cordato, N. J., Halliday, G. M., Caine, D. and Morris, J. G. (2006). Comparison of motor, cognitive, and behavioral features in progressive supranuclear palsy and Parkinson's disease. Movement Disorders, 21, 5, 632–638.CrossRefGoogle ScholarPubMed
Cummings, J. L., Mega, M. S., Gray, K., Rosenberg-Thompson, S., Carusi, D. A. and Gornbein, J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308–2314.CrossRefGoogle ScholarPubMed
Czernecki, V. et al. (2008). Apathy following subthalamic stimulation in Parkinson disease: a dopamine responsive symptom. Movement Disorders, 23, 7, 964–969.CrossRefGoogle ScholarPubMed
Golbe, L. I., Davis, P. H., Schoenberg, B. S. and Duvoisin, R. C. (1988). Prevalence and natural history of progressive supranuclear palsy. Neurology, 38, 1031–1034.CrossRefGoogle ScholarPubMed
Kertesz, A., Nadkarni, N., Davidsob, W. and Thomas, A. W. (2000). The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia. Journal of the International Neuropsychological Society, 6, 460–468.CrossRefGoogle ScholarPubMed
Kertesz, A., Hillis, A. and Munoz, D. (2003). Frontotemporal degeneration, Pick's Disease, Pick Complex and Ravel. Annals of Neurology, 54, S5, 1–2.CrossRefGoogle ScholarPubMed
Kertesz, A., McMonagle, P., Blair, M., Davidson, W. and Munoz, D. G. (2005). The evolution and pathology of frontotemporal dementia. Brain, 128, 1996–2005.CrossRefGoogle ScholarPubMed
Lantos, P. L. (2000). Diagnostic criteria for corticobasal degeneration. Journal of Neurology Neurosurgery and Psychiatry, 69, 705–706.CrossRefGoogle ScholarPubMed
Levy, R. and Czernecki, V. (2006). Apathy and basal ganglia. Journal of Neurology, 253 (Suppl. 7), 54–61.CrossRefGoogle ScholarPubMed
Litvan, I. (1999). Recent advances in atypical parkinsonian disorders. Current Opinion in Neurology, 12, 441–446.CrossRefGoogle ScholarPubMed
Litvan, I. et al. (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology, 47, 1–9.CrossRefGoogle ScholarPubMed
Mahapatra, R. K., Edwards, M. J., Schott, J. M. and Bhatia, K. P. (2004). Corticobasal degeneration. Lancet Neurology, 3, 736–43CrossRefGoogle ScholarPubMed
O'Keeffe, F. M. et al. (2007). Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy. Brain, 130, 753–764.CrossRefGoogle ScholarPubMed
Padovani, A. et al. (2006). Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy. Journal of Neurology Neurosurgery and Psychiatry, 77, 457–463.CrossRefGoogle ScholarPubMed
Rebeiz, J. J., Kolodny, E. H. and Richardson, E. P. Jr. (1967). Corticodentatonigral degeneration with neuronal achromasia: a progressive disorder of late adult life. Transactions of the American Neurological Association, 92, 23–26.Google ScholarPubMed
Spillantini, M. G. and Goedert, M. (2000). Tau mutations in familial frontotemporal dementia. Brain, 123, 857–859.CrossRefGoogle ScholarPubMed
Steele, J. C., Richardson, J. C. and Olszewski, J. (1964). Progressive Supranuclear Palsy. A heterogeneous degeneration involving the brainstem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Archives of Neurology, 10, 333–359.CrossRefGoogle ScholarPubMed