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Homocysteine levels and dementia risk in Yoruba and African Americans

Published online by Cambridge University Press:  30 July 2013

Hugh C. Hendrie ,
Olusegun Baiyewu ,
Kathleen A. Lane ,
Christianna Purnell ,
Sujuan Gao ,
Ann Hake ,
Adesola Ogunniyi ,
Oye Gureje ,
Frederick W. Unverzagt  and
Jill Murrell
...Show all authors
Hugh C. Hendrie*
Affiliation:
Indiana University Center for Aging Research, Indianapolis, Indiana, USA Regenstrief Institute Inc., Indianapolis, Indiana, USA Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Olusegun Baiyewu
Affiliation:
Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria
Kathleen A. Lane
Affiliation:
Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Christianna Purnell
Affiliation:
Regenstrief Institute Inc., Indianapolis, Indiana, USA
Sujuan Gao
Affiliation:
Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Ann Hake
Affiliation:
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Adesola Ogunniyi
Affiliation:
Department of Medicine, College of Medicine, University of Ibadan, Nigeria
Oye Gureje
Affiliation:
Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria
Frederick W. Unverzagt
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Jill Murrell
Affiliation:
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Mark A. Deeg
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
Kathleen Hall
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
*
Correspondence should be addressed to: Hugh C. Hendrie, MB, ChB, DSc, Indiana University Center for Aging Research, 410 W 10th St., Suite 2000 Indianapolis, IN 46202, USA. Phone: +(317)-423-5591; Fax: +(317)-423-5695. Email: [email protected].
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Abstract

Background:

High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa.

Methods:

In this longitudinal study of two community-dwelling cohorts of elderly Yoruba and African Americans, levels of homocysteine, vitamin B12 and folate were measured from blood samples taken in 2001. These levels were compared in two groups, participants who developed incident dementia in the follow-up until 2009 (59 Yoruba and 101 African Americans) and participants who were diagnosed as cognitively normal or in the good performance category at their last follow-up (760 Yoruba and 811 African Americans). Homocysteine levels were divided into quartiles for each site.

Results:

After adjusting for age, education, possession of ApoE, smoking, and time of enrollment the higher quartiles of homocysteine were associated with a non-significant increase in dementia risk in the Yoruba (homocysteine quartile 4 vs. 1 OR: 2.19, 95% CI 0.95–5.07, p = 0.066). For the African Americans, there was a similar but non-significant relationship between higher homocysteine levels and dementia risk. There were no significant relationships between levels of vitamin B12 and folate and incident dementia in either site although folate levels were lower and vitamin B12 levers were higher in the Yoruba than in the African Americans.

Conclusions:

Increased homocysteine levels were associated with a similar but non-significant increase in dementia risk for both Yoruba and African Americans despite significant differences in folate levels between the two sites.

Keywords

dementiaAlzheimer’s diseasehomocysteineAfrican AmericansYoruba
Type
Research Article
Information
International Psychogeriatrics , Volume 25 , Issue 11 , November 2013 , pp. 1859 - 1866
Copyright
Copyright © International Psychogeriatric Association 2013 

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