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Disease-specific anxiety symptomatology in Parkinson's disease

Published online by Cambridge University Press:  10 February 2016

Nadeeka N. W. Dissanayaka ,
John D. O'Sullivan ,
Nancy A. Pachana ,
Rodney Marsh ,
Peter A. Silburn ,
Elizabeth X. White ,
Elizabeth Torbey ,
George D. Mellick ,
David A. Copland  and
Gerard J. Byrne
Nadeeka N. W. Dissanayaka*
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia
John D. O'Sullivan
Affiliation:
Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Nancy A. Pachana
Affiliation:
School of Psychology, The University of Queensland, Brisbane, Australia
Rodney Marsh
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia Mental Health Service, Royal Brisbane & Women's Hospital, Herston, Brisbane, Australia
Peter A. Silburn
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Elizabeth X. White
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia
Elizabeth Torbey
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia
George D. Mellick
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia Neurology Research Centre, Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, Australia Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Australia
David A. Copland
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Health & Rehabilitation Sciences, The University of Queensland, St Lucia, Brisbane, Australia
Gerard J. Byrne
Affiliation:
UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, The University of Queensland, Brisbane, Australia School of Psychology, The University of Queensland, Brisbane, Australia School of Medicine, Royal Brisbane & Women's Hospital, The University of Queensland, Herston, Brisbane, Australia Mental Health Service, Royal Brisbane & Women's Hospital, Herston, Brisbane, Australia
*
Correspondence should be addressed to: Nadeeka Dissanayaka, The University of Queensland, UQ Centre for Clinical Research, Building 71/918 Royal Brisbane & Women's Hospital, Herston QLD4029, Brisbane, Australia. Phone: +61 7 33465577; +61 405715622. E-mail: [email protected].
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Abstract

Background:

Symptoms of anxiety relating to Parkinson's disease (PD) occur commonly and include symptomatology associated with motor disability and complications arising from PD medication. However, there have been relatively few attempts to profile such disease-specific anxiety symptoms in PD. Consequently, anxiety in PD is underdiagnosed and undertreated. The present study characterizes PD-related anxiety symptoms to assist with the more accurate assessment and treatment of anxiety in PD.

Methods:

Ninety non-demented PD patients underwent a semi-structured diagnostic assessment targeting anxiety symptoms using relevant sections of the Mini International Neuropsychiatric Interview (MINI-plus). In addition, they were assessed for the presence of 30 PD-related anxiety symptoms derived from the literature, the clinical experience of an expert panel and the PD Anxiety-Motor Complications Questionnaire (PDAMCQ). The onset of anxiety in relation to the diagnosis of PD was determined.

Results:

Frequent (>25%) PD-specific anxiety symptoms included distress, worry, fear, agitation, embarrassment, and social withdrawal due to motor symptoms and PD medication complications, and were experienced more commonly in patients meeting DSM-IV criteria for an anxiety disorder. The onset of common anxiety disorders was observed equally before and after a diagnosis of PD. Patients in a residual group of Anxiety Not Otherwise Specified had an onset of anxiety after a diagnosis of PD.

Conclusion:

Careful characterization of PD-specific anxiety symptomatology provides a basis for conceptualizing anxiety and assists with the development of a new PD-specific measure to accurately assess anxiety in PD.

Keywords

anxietyParkinson's Diseasesymptomatologyonset
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 7 , July 2016 , pp. 1153 - 1163
Copyright
Copyright © International Psychogeriatric Association 2016 

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References

Ambermoon, P., Carter, A., Hall, W., Dissanayaka, N. and O'Sullivan, J. (2012). Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?. Addiction, 107, 241–247.CrossRefGoogle Scholar
Ambermoon, P., Carter, A., Hall, W. D., Dissanayaka, N. N. and O'Sullivan, J. D. (2011). Impulse control disorders in patients with Parkinson's disease receiving dopamine replacement therapy: evidence and implications for the addictions field. Addiction, 106, 283–293.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. Washington, DC: American Psychiatric Association.Google Scholar
Berg, D. et al. (2013). Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities. The Lancet Neurology, 12, 514–524.CrossRefGoogle ScholarPubMed
Bower, J. H. et al. (2010). Anxious personality predicts an increased risk of Parkinson's disease. Movement Disorders, 25, 2105–2113.CrossRefGoogle ScholarPubMed
Brown, R. G. et al. (2011). Depression and anxiety related subtypes in Parkinson's disease. Journal Neurology Neurosurgery Psychiatry, 82, 803–809.CrossRefGoogle ScholarPubMed
Chen, J. J. and Marsh, L. (2014). Anxiety in Parkinson's disease: identification and management. Therapeutic Advances in Neurological Disorders, 7, 52–59.CrossRefGoogle ScholarPubMed
Chen, Y. K. et al. (2010). Anxiety disorders in Chinese patients with Parkinson's disease. The International Journal of Psychiatry in Medicine, 40, 97–107.CrossRefGoogle ScholarPubMed
Dissanayaka, N. N., Sellbach, A., Silburn, P. A., O'Sullivan, J. D., Marsh, R. and Mellick, G. D. (2011). Factors associated with depression in Parkinson's disease. Journal of Affective Disorders, 132, 82–88.CrossRefGoogle ScholarPubMed
Dissanayaka, N. N., Silburn, P. A., O'Sullivan, J. D. and Mellick, G. D. (2009). Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease. Movements Disorders, 24, 111–115.CrossRefGoogle Scholar
Dissanayaka, N. N. W., Torbey, E. and Pachana, N. (2015a). Anxiety rating scales in Parkinson's disease: a critical review updating recent literature. International Psychogeriatrics, Epub ahead of print. PMID: 26100107.CrossRefGoogle Scholar
Dissanayaka, N. N. W., White, E., O'Sullivan, J. D., Marsh, R., Pachana, N. A. and Byrne, G. J. (2014). The clinical spectrum of anxiety in Parkinson's disease. Movement Disorders, 29, 967–975.CrossRefGoogle ScholarPubMed
Dissanayaka, N. N. W. et al. (2010). Anxiety disorders in Parkinson's disease: prevalence and risk factors. Movement Disorders, 25, 838–845.CrossRefGoogle ScholarPubMed
Dissanayaka, N. N. W. et al. (2015b). Characteristics and treatment of anxiety disorders in Parkinson's disease. Movement Disorder Clinical Practice, 2, 155–162.CrossRefGoogle ScholarPubMed
Forjaz, M. J. et al. (2013). Rasch analysis of anxiety scales in Parkinson's disease. Journal of Psychosomatic Research, 74, 414–419.CrossRefGoogle ScholarPubMed
Goetz, C. G. et al. (2007). Movement Disorder Society-sponsored revision of the Unified Parkinson's disease rating scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 22, 41–47.CrossRefGoogle ScholarPubMed
Jacob, E. L., Gatto, N. M., Thompson, A., Bordelon, Y. and Ritz, B. (2010). Occurrence of depression and anxiety prior to Parkinson's disease. Parkinsonism and Related Disorders, 16, 576–581.CrossRefGoogle ScholarPubMed
Kummer, A., Cardoso, F. and Teixeira, A. L. (2010). Generalized anxiety disorder and the hamilton anxiety rating scale in Parkinson's disease. Arquivos de Neuropsiquiatria, 68, 495–501.CrossRefGoogle ScholarPubMed
Lauterbach, E. C., Freeman, A. and Vogel, R. L. (2003). Correlates of generalized anxiety and panic attacks in dystonia and Parkinson disease. Cognitive and Behavioral Neurology, 16, 225–233.CrossRefGoogle ScholarPubMed
Lauterbach, E. C., Freeman, A. and Vogel, R. L. (2004). Differential DSM-III psychiatric disorder prevalence profiles in dystonia and Parkinson's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 16, 29–36.CrossRefGoogle ScholarPubMed
Leentjens, A. F., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I. H. and Starkstein, S. E. (2011a). Symptomatology and markers of anxiety disorders in Parkinson's disease: a cross-sectional study. Movement Disorders, 26, 484–492.CrossRefGoogle ScholarPubMed
Leentjens, A. F., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I. H. and Starkstein, S. E. (2012). Anxiety and motor fluctuations in Parkinson's disease: a cross-sectional observational study. Parkinsonism and Related Disorders, 18, 1084–1088.CrossRefGoogle ScholarPubMed
Leentjens, A. F., Dujardin, K., Marsh, L., Richard, I. H., Starkstein, S. E. and Martinez-Martin, P. (2011b). Anxiety rating scales in Parkinson's disease: a validation study of the Hamilton anxiety rating scale, the Beck anxiety inventory, and the hospital anxiety and depression scale. Movement Disorders, 26, 407–415.CrossRefGoogle ScholarPubMed
Leentjens, A. F., Dujardin, K., Pontone, G. M., Starkstein, S. E., Weintraub, D. and Martinez-Martin, P. (2014). The Parkinson anxiety scale (PAS): development and validation of a new anxiety scale. Movement Disorders, 29, 1035–1043.CrossRefGoogle ScholarPubMed
Leentjens, A. F. et al. (2008). Anxiety rating scales in Parkinson's disease: critique and recommendations. Movement Disorders, 23, 2015–2025.CrossRefGoogle ScholarPubMed
Macht, M., Schwarz, R. and Ellgring, H. (2005). Patterns of psychological problems in Parkinson's disease. Acta Neurologica Scandinavica, 111, 95–101.CrossRefGoogle ScholarPubMed
Marinus, J., Leentjens, A. F., Visser, M., Stiggelbout, A. M. and van Hilten, J. J. (2002). Evaluation of the hospital anxiety and depression scale in patients with Parkinson's disease. Clinical Neuropharmacology, 25, 318–324.CrossRefGoogle ScholarPubMed
Marsh, L. (2000). Anxiety disorders in Parkinson's disease. International Review of Psychiatry, 12, 307–318.CrossRefGoogle Scholar
Marsh, L., McDonald, W. M., Cummings, J. and Ravina, B. (2006). Provisional diagnostic criteria for depression in Parkinson's disease: report of an NINDS/NIMH Work Group. Movement Disorders, 21, 148–158.CrossRefGoogle ScholarPubMed
Martinez-Martin, P. et al. (2013). Designing a new scale to measure anxiety symptoms in Parkinson's disease: Item selection based on canonical correlation analysis. European Journal of Neurology, 20, 1198–1203.CrossRefGoogle ScholarPubMed
Matheson, S. F. et al. (2012). Validity and reliability of the Geriatric Anxiety Inventory in Parkinson's disease. Australasian Journal on Ageing, 31, 13–16.CrossRefGoogle ScholarPubMed
Menza, M. A., Robertson-Hoffman, D. E. and Bonapace, A. S. (1993). Parkinson's disease and anxiety: comorbidity with depression. Biological Psychiatry, 34, 465–470.CrossRefGoogle ScholarPubMed
Molloy, D. W., Alemayehu, E. and Roberts, R. (1991). Reliability of a standardized mini-mental-state-examination compared with the traditional mini-mental-state-examination. The American Journal of Psychiatry, 148, 102–105.Google ScholarPubMed
Mondolo, F., Jahanshahi, M., Grana, A., Biasutti, E., Cacciatori, E. and Di Benedetto, P. (2007). Evaluation of anxiety in Parkinson's disease with some commonly used rating scales. Neurological Sciences, 28, 270–275.CrossRefGoogle ScholarPubMed
Pachana, N. A. et al. (2013). Clinical issues in the treatment of anxiety and depression in older adults with Parkinson's disease. Movement Disorders, 28, 1930–1934.CrossRefGoogle ScholarPubMed
Pagonabarraga, J., Kulisevsky, J., Llebaria, G., Garcia-Sanchez, C., Pascual-Sedano, B. and Gironell, A. (2008). Parkinson's disease-cognitive rating scale: a new cognitive scale specific for Parkinson's disease. Movement Disorders, 23, 998–1005.CrossRefGoogle Scholar
Peron, J., Dondaine, T., Le Jeune, F., Grandjean, D. and Verin, M. (2012). Emotional processing in Parkinson's disease: a systematic review. Movement Disorders, 27, 186–199.CrossRefGoogle ScholarPubMed
Pontone, G. M. et al. (2009). Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease. Movement Disorders, 24, 1333–1338.CrossRefGoogle ScholarPubMed
Qureshi, S. U., Amspoker, A. B., Calleo, J. S., Kunik, M. E. and Marsh, L. (2012). Anxiety disorders, physical illnesses, and health care utilization in older male veterans with Parkinson disease and comorbid depression. Journal of Geriatric Psychiatry and Neurology, 25, 233–239.CrossRefGoogle ScholarPubMed
Sheehan, D. V. et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 20 (Suppl. 59), 22–33.Google Scholar
Starkstein, S. E. et al. (2014). Anxiety has specific syndromal profiles in Parkinson disease: a data-driven approach. The American Journal of Geriatric Psychiatry, 22, 1410–1417.CrossRefGoogle ScholarPubMed
Stein, M. B., Heuser, I. J., Juncos, J. L. and Uhde, T. W. (1990). Anxiety disorders in patients with Parkinson's disease. The American Journal of Psychiatry, 147, 217–220.Google ScholarPubMed
Torbey, E., Pachana, N. A. and Dissanayaka, N. N. (2015). Depression rating scales in Parkinson's disease: a critical review updating recent literature. Journal of Affective Disorders, 184, 216–224.CrossRefGoogle ScholarPubMed
Uitti, R. J. (2009). Parkinson's disease and issues related to driving. Parkinsonism and Related Disorders, 15 (Suppl. 3), S122–125.CrossRefGoogle ScholarPubMed