Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-25T04:45:49.312Z Has data issue: false hasContentIssue false

Dimensions of positive symptoms in late versus early onset psychosis

Published online by Cambridge University Press:  23 October 2012

Oliver Mason*
Affiliation:
Research Department of Clinical, Educational and Health Psychology, University College London, London, UK North East London Foundation NHS Trust, Ilford, UK
Joshua Stott
Affiliation:
Research Department of Clinical, Educational and Health Psychology, University College London, London, UK
Ruth Sweeting
Affiliation:
Research Department of Clinical, Educational and Health Psychology, University College London, London, UK
*
Correspondence should be addressed to: Dr. Oliver Mason, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London WC1E 6BT, UK. Phone: +44-0207-679-8230; Fax: +44-0207-916-1989. Email: [email protected].
Get access

Abstract

Background: Casenote studies have characterized late onset schizophrenia (LOS) and related psychoses as somewhat different symptomatically from patients with an early onset schizophrenia (EOS). This study examined a range of phenomenological aspects of delusions and hallucinations as well as traditional symptom measures in both groups.

Methods: 34 LOS and 235 EOS completed the Positive and Negative Syndrome Scale, the Psychotic Symptom Rating Scales, and the Beck Depression and Anxiety inventories. Subgroups experiencing delusions were compared matching for chronological age and gender, and also when matched for chronicity and gender.

Results: Delusions were very common at over 80% in both groups. LOS participants with delusions exhibited greater suspiciousness/paranoia, greater belief-conviction, and reduced insight when compared with the EOS group. These findings remained when matching for chronicity of illness, but disappeared when matching for chronological age. Hallucinations were surprisingly rarer in LOS (35%) than EOS (57%), with half the LOS group reporting whispers rather than clearly audible sounds. In general, anxiety, depression, and distress were as marked in LOS and EOS.

Conclusions: Similarities between EOS and LOS far outweighed the differences across a range of symptoms and measures. Greater delusional conviction, paranoia, and poorer insight in LOS were associated with the later age of onset rather than relating to chronicity of illness. As belief-conviction in LOS was not associated with increased grandiosity, disorientation, or unusualness of thought content, as it was in EOS, delusional conviction may be determined somewhat differently later in life.

Type
Research Article
Copyright
Copyright © International Psychogeriatric Association 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Almeida, O. P., Howard, R. J., Levy, R. and David, A. S. (1995). Psychotic states arising in late-life (late paraphrenia): the role of risk-factors. British Journal of Psychiatry, 166, 215228.CrossRefGoogle ScholarPubMed
Almeida, O. P., Levy, R., Howard, R. J. and David, A. S. (1996). Insight and paranoid disorders in late life (late paraphrenia). International Journal of Geriatric Psychiatry, 11, 653658.3.0.CO;2-9>CrossRefGoogle Scholar
Beck, A., Epstein, N., Brown, G. and Steer, R. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893897.CrossRefGoogle ScholarPubMed
Beck, A. T., Steer, R. A. and Brown, G. K. (1996). The Beck Depression Inventory-II: Manual. San Antonio, TX: Psychological Corporation.Google Scholar
Castle, D. J., Wessely, S., Howard, R. and Murray, R. M. (1997). Schizophrenia with onset at the extremes of adult life. International Journal of Geriatric Psychiatry, 12, 712717.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Cohen, C. I., Vahia, I., Reyes, P., Diwan, S., Bankole, A. O. and Palekar, N. (2008). Schizophrenia in later life: clinical symptoms and social well-being. Psychiatric Services, 59, 232234.CrossRefGoogle ScholarPubMed
Drake, R., Haddock, G., Tarrier, N., Bentall, R. and Lewis, S. (2007). The Psychotic Symptom Rating Scales (PSYRATS): their usefulness and properties in first episode psychosis. Schizophrenia Research, 89, 119122.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). Mini-mental state: practical method for grading cognitive state of patients for clinician. Journal of Psychiatric Research, 12, 189198.CrossRefGoogle ScholarPubMed
Haddock, G., McCarron, J., Tarrier, N. and Faragher, E. B. (1999). Scales to measure dimensions of hallucinations and delusions: the Psychotic Symptom Rating Scales (PSYRATS). Psychological Medicine, 29, 879889.CrossRefGoogle ScholarPubMed
Häfner, H., Riecherrossler, A., Anderheiden, W., Maurer, K., Fatkenheuer, B. and Loffler, W. (1993). Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia. Psychological Medicine, 23, 925940.CrossRefGoogle ScholarPubMed
Häfner, H., Hambrecht, M., Loffler, W., Munk-Jorgensen, P. and Riecher-Rossler, A. (1998). Is schizophrenia a disorder of all ages? A comparison of first episodes and early course across the life-cycle. Psychological Medicine, 28, 351365.CrossRefGoogle Scholar
Hassett, A. (1997). The case for a psychological perspective on late-onset psychosis. Australian and New Zealand Journal of Psychiatry, 31, 6875.CrossRefGoogle ScholarPubMed
Howard, R., Castle, D., Wessely, S. and Murray, R. (1993a). A comparative study of 470 cases of early-onset and late-onset schizophrenia. British Journal of Psychiatry, 163, 352357.CrossRefGoogle ScholarPubMed
Howard, R., Almeida, O. and Levy, R. (1993b). Schizophrenic symptoms in late paraphrenia. Psychopathology, 26, 95101.CrossRefGoogle ScholarPubMed
Howard, R., Rabins, P. V., Seeman, M. V. and Jeste, D. V. (2000). Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. American Journal of Psychiatry, 157, 172178.CrossRefGoogle ScholarPubMed
Huang, C. and Zhang, Y. L. (2009). Clinical differences between late-onset and early-onset chronically hospitalized elderly schizophrenic patients in Taiwan. International Journal of Geriatric Psychiatry, 24, 11661172.CrossRefGoogle ScholarPubMed
Jeste, D. V., Harris, M. J., Krull, A., Kuck, J., McAdams, L. A. and Heaton, R. (1995). Clinical and neuropsychological characteristics of patients with late-onset schizophrenia. American Journal of Psychiatry, 152, 722730.Google ScholarPubMed
Kay, S. R., Opler, L. A. and Lindenmayer, J.-P. (1989). The Positive and Negative Syndrome Scale: PANSS rationale and standardization. British Journal of Psychiatry, 155, 5965.CrossRefGoogle Scholar
Mayer, C., Kelterborn, G. and Naber, D. (1993). Age of onset in schizophrenia: relations to psychopathology and gender. British Journal of Psychiatry, 162, 665671.CrossRefGoogle ScholarPubMed
McPherson, M., Smith-Lovin, L. and Brashears, M. (2006). Social isolation in America: changes in core discussion networks over two decades. American Sociological Review, 71, 353375.CrossRefGoogle Scholar
Mitter, P., Reeves, S., Romero-Rubiales, F., Bell, P., Stewart, R. and Howard, R. (2005). Migrant status, age, gender and social isolation in very late-onset schizophrenia-like psychosis. International Journal of Geriatric Psychiatry, 20, 10461051.CrossRefGoogle ScholarPubMed
Moore, R., Blackwood, N., Corcoran, R., Rowse, G., Kinderman, P. and Bentall, R. (2006). Misunderstanding the intentions of others: an exploratory study of the cognitive etiology of persecutory delusions in very late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry, 14, 410418.CrossRefGoogle ScholarPubMed
Pearlson, G. D., Kreger, L., Rabins, P. V., Chase, G. A., Cohen, B. and Wirth, J. B. (1989). A chart review study of late-onset and early-onset schizophrenia. American Journal of Psychiatry, 146, 15681574.Google ScholarPubMed
Prager, S. and Jeste, D. V. (1993). Sensory impairment in late-life schizophrenia. Schizophrenia Bulletin, 19, 755772.CrossRefGoogle ScholarPubMed
Sato, T., Bottlender, R., Schröter, A. and Möller, H. J. (2004). Psychopathology of early-onset versus late-onset schizophrenia revisited: an observation of 473 neuroleptic-naive patients before and after first-admission treatments. Schizophrenia Research, 67, 175183.CrossRefGoogle ScholarPubMed
Vahia, I. V., Palmer, B. W., Depp, C., Fellows, I., Golshan, S. and Kraemer, H. C. (2010). Is late-onset schizophrenia a subtype of schizophrenia? Acta Psychiatrica Scandinavica, 122, 414426.CrossRefGoogle ScholarPubMed
Van Os, J., Howard, R., Takei, N. and Murray, R. (1995). Increasing age is a risk factor for psychosis in the elderly Social Psychiatry and Psychiatric Epidemiology, 30, 161164.CrossRefGoogle ScholarPubMed