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Depressive symptoms and depression in people screened positive for dementia in primary care – results of the DelpHi-study

Published online by Cambridge University Press:  20 January 2016

Jochen René Thyrian ,
Tilly Eichler ,
Melanie Reimann ,
Diana Wucherer ,
Adina Dreier ,
Bernhard Michalowsky  and
Wolfgang Hoffmann
Jochen René Thyrian*
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Tilly Eichler
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Melanie Reimann
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Diana Wucherer
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Adina Dreier
Affiliation:
Institute for Community Medicine, University of Greifswald, Epidemiology of Health Care and Community Health, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Bernhard Michalowsky
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany
Wolfgang Hoffmann
Affiliation:
German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany Institute for Community Medicine, University of Greifswald, Epidemiology of Health Care and Community Health, Ellernholzstr. 1-2, 17489 Greifswald, Germany
*
Correspondence should be addressed to: Jochen René Thyrian, German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Ellernholzstr. 1-2, 17489 Greifswald, Germany. Phone: +49 3834 867592; Fax: +49 3834 86 19551. Email: [email protected].
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Abstract

Background:

Dementia and depression are common syndromes in the elderly. There is lack of knowledge concerning the frequency of depressive symptoms in people with dementia (PWD) and factors associated with depression. The aim of this analysis is to (a) describe the frequency of depressive symptoms in people screened positive for dementia, (b) describe differences between PWD with and without depressive symptoms, and (c) analyze associations between depressive symptoms and other dementia-related variables.

Methods:

Analyses are based on data of the GP-based intervention trial DelpHi-MV. A sample of 430 (6.29%) people screened positive for dementia in primary care was analyzed regarding depression according to the German version of the Geriatric Depression Scale (GDS, 15-items), demographic variables, and dementia/depression-related variables. Multivariate analyses were conducted to identify factors associated with depressive symptoms.

Results:

The mean GDS-score of depressive symptoms in n = 430 PWD was m = 3.21 (SD 2.45) with 67 PWD (15.55%) showing clinically relevant depression (GDS < 5) m = 7.71 (SD = 1.92). A total of n = 72 (16.74%) received a formal diagnosis of depression and n = 62 (14.42%) received antidepressive drug treatment. Depressive symptoms are significantly associated with age (OR = 0.93), functional impairment (OR = 1.36), and quality of life (OR = 0.01, CI: 0.00–0.06).

Conclusion:

Our results support previous findings that clinically relevant depressive symptoms are more common in people screened positive for dementia than in the general population and are often missed or mismanaged. Our findings underline the importance of managing quality of life, functional status, or depressive symptoms. Also, the results highlight the benefit of including the partner (and probably other carers) for adequate treatment of PWD.

Keywords

depressiondementiaprimary careprimary healthcare
Type
Research Article
Information
International Psychogeriatrics , Volume 28 , Issue 6 , June 2016 , pp. 929 - 937
Copyright
Copyright © International Psychogeriatric Association 2016 

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