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Dementia time to death: a systematic literature review on survival time and years of life lost in people with dementia

Published online by Cambridge University Press:  13 February 2012

Henry Brodaty ,
Katrin Seeher  and
Louisa Gibson
Henry Brodaty*
Affiliation:
Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, NSW, Australia
Katrin Seeher
Affiliation:
Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, NSW, Australia
Louisa Gibson
Affiliation:
Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, NSW, Australia
*
Correspondence should be addressed to: Professor Henry Brodaty, Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Euroa Centre, Avoca Street, Gate 6, Randwick, NSW 2031, Australia. Phone: +61-2-9382-3759; Fax: +61-2-9382-3762. Email: [email protected].
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Abstract

Background: Life expectancy with dementia directly influences rates of prevalence and service needs and is a common question posed by families and patients. As well as years of survival, it is useful to consider years of life lost after a diagnosis of dementia.

Methods: We systematically reviewed the literature on mortality and survival with dementia which were compared to estimated life expectancies in the general population. Both were then compared by age (under 65 years vs. 65+ years), gender, dementia type, severity, and two epochs (prior to and after introduction of cholinesterase inhibitors in 1997).

Results: Survival after a diagnosis of dementia varies considerably and depends on numerous factors and their complex interaction. Relative loss of life expectancy decreases with age at diagnosis across varying gender, dementia subtypes (except for frontotemporal dementia and dementia with Lewy bodies), and severity stages. Numerous study deficiencies precluded a meta-analysis of survival in dementia.

Conclusion: Estimates of years of life lost through dementia may be helpful for patients and their families. Recommendations for future research methods are proposed.

Keywords

dementiasurvivalmortalitydeathlife expectancyAlzheimer's disease
Type
Review Article
Information
International Psychogeriatrics , Volume 24 , Issue 7 , July 2012 , pp. 1034 - 1045
Copyright
Copyright © International Psychogeriatric Association 2012

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References

Aevarsson, O., Svanborg, A. and Skoog, I. (1998). Seven-year survival rate after age 85 years: relation to Alzheimer disease and vascular dementia. Archives of Neurology, 55, 1226–1232.CrossRefGoogle ScholarPubMed
Aguero-Torres, H. et al. (1999). Mortality from dementia in advanced age: a 5-year follow-up study of incident dementia cases. Journal of Clinical Epidemiology, 52, 737–743.CrossRefGoogle ScholarPubMed
Aguero-Torres, H., Qiu, C., Winblad, B. and Fratiglioni, L. (2002). Dementing disorders in the elderly: evolution of disease severity over 7 years. Alzheimer Disease & Associated Disorders, 16, 221–227.CrossRefGoogle ScholarPubMed
Alladi, S. et al. (2007). Focal cortical presentations of Alzheimer's disease. Brain, 130, 2636–2645.CrossRefGoogle ScholarPubMed
Almeida, O. P. and Xiao, J. (2007). Mortality associated with incident mental health disorder after stroke. Australian and New Zealand Journal of Psychiatry, 41, 274–281.CrossRefGoogle ScholarPubMed
Andersen, K., Lolk, A., Martinussen, T. and Kragh-Sorensen, P. (2010). Very mild to severe dementia and mortality: a 14-year follow-up – The Odense study. Dementia & Geriatric Cognitive Disorders, 29, 61–67.CrossRefGoogle ScholarPubMed
Barclay, L. L. et al. (1985a). Factors associated with duration of survival in Alzheimer's disease. Biological Psychiatry, 20, 86–93.Google Scholar
Barclay, L. L., Zemcov, A., Blass, J. P. and Sansone, J. (1985b). Survival in Alzheimer's disease and vascular dementias. Neurology, 35, 834–840.CrossRefGoogle ScholarPubMed
Beard, C. M. et al. (1994). Are patients with Alzheimer's disease surviving longer in recent years? Neurology, 44, 1869–1871.CrossRefGoogle ScholarPubMed
Bhargava, D. et al. (2006). Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease. Journal of Geriatric Psychiatry & Neurology, 19, 78–82.Google Scholar
Boersma, F., van den Brink, W., Deeg, D. J., Eefsting, J. A. and van Tilburg, W. (1999). Survival in a population-based cohort of dementia patients: predictors and causes of mortality. International Journal of Geriatric Psychiatry, 14, 748–753.Google Scholar
Börjesson-Hanson, A., Gustafson, D., Skoog, I., Borjesson-Hanson, A., Gustafson, D. and Skoog, I. (2007). Five-year mortality in relation to dementia and cognitive function in 95-year-olds. Neurology, 69, 2069–2075.Google Scholar
Borroni, B. et al. (2009). Survival in frontotemporal lobar degeneration and related disorders: latent class predictors and brain functional correlates. Rejuvenation Research, 12, 33–44.Google Scholar
Bowen, J., Malter, A., Sheppard, L. and Kukull, W. et al. (1996). Predictors of mortality in patients diagnosed with probable Alzheimer's disease. Neurology, 47, 433–439.Google Scholar
Bracco, L., Gallato, R., Grigoletto, F. and Lippi, A. et al. (1994). Factors affecting course and survival in Alzheimer's disease: a 9-year longitudinal study. Archives of Neurology, 51, 1213–1219.CrossRefGoogle ScholarPubMed
Brookmeyer, R., Corrada, M. M., Curriero, F. C. and Kawas, C. (2002). Survival following a diagnosis of Alzheimer disease. Archives of Neurology, 59, 1764–1767.CrossRefGoogle ScholarPubMed
Bruandet, A. et al. (2009). Alzheimer disease with cerebrovascular disease and vascular dementia: clinical features and course compared with Alzheimer disease. Journal of Neurology, Neurosurgery & Psychiatry, 80, 133–139.CrossRefGoogle ScholarPubMed
Claus, J. J. et al. (1998). Predicting survival in patients with early Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 9, 284–293.CrossRefGoogle ScholarPubMed
Consentino, S., Scarmeas, N., Albert, S. M. and Stern, Y. (2006). Verbal fluency predicts mortality in Alzheimer's disease. Cognitive and Behavioral Neurology, 19, 123–129.Google Scholar
Doody, R., Massman, P. and Dunn, K. (2001). A method of estimating progression rates in Alzheimer disease. Archives of Neurology, 58, 449–454.Google Scholar
Doody, R. et al. (2005). Changing patient characteristics and survival experience in an Alzheimer's center patient cohort. Dementia and Geriatric Cognitive Disorders, 20, 198–208.CrossRefGoogle Scholar
Drachman, D. A., O'Donnell, B. F., Lew, R. A. and Swearer, J. M. (1990). The prognosis in Alzheimer's disease. “How far” rather than “how fast” best predicts the course. Archives of Neurology, 47, 851–856.CrossRefGoogle Scholar
Eisai Inc. and Pfizer Inc. (2008). About Aricept. Available at http://www.aricept.com/about.html/.Google Scholar
Emilien, G., Beyreuther, K., Masters, C. L. and Maloteaux, J. M. (2000). Prospects for pharmacological intervention in Alzheimer disease. Archives of Neurology, 57, 454–459.CrossRefGoogle ScholarPubMed
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Kawas, C. H. and Jagust, W. (2005). Survival following dementia onset: Alzheimer's disease and vascular dementia. Journal of the Neurological Sciences, 229–230, 43–49.Google Scholar
Forbes, W. F., Gentleman, J. F. and Park, E. (1995). Dementia and age at death. Experimental Gerontology, 30, 445–453.CrossRefGoogle ScholarPubMed
Ganguli, M., Dodge, H. H., Shen, C., Pandav, R. S. and DeKosky, S. T. (2005). Alzheimer disease and mortality: a 15-year epidemiological study. Archives of Neurology, 62, 779–784.Google Scholar
Garcin, B. et al. (2009). Determinants of survival in behavioral variant frontotemporal dementia. Neurology, 73, 1656–1661.Google Scholar
Gasper, M. C., Ott, B. R. and Lapane, K. L. (2005). Is donepezil therapy associated with reduced mortality in nursing home residents with dementia? American Journal of Geriatric Pharmacotherapy, 3, 1–7.CrossRefGoogle ScholarPubMed
Gühne, U., Riedel-Heller, S. and Angermeyer, M. C. (2005). Mortality in dementia: a systematic review. Neuroepidemiology, 25, 153–162.Google Scholar
Heeren, T. J., van Hemert, A. M. and Rooymans, H. G. (1992). A community-based study of survival in dementia. Acta Psychiatrica Scandinavica, 85, 415–418.Google Scholar
Helmer, C., Joly, P., Letenneur, L., Commenges, D. and Dartigues, J. F. (2001). Mortality with dementia: results from a French prospective community-based cohort. American Journal of Epidemiology, 154, 642–648.CrossRefGoogle ScholarPubMed
Helzner, E. P., Scarmeas, N., Cosentino, S., Tang, M. X., Schupf, N. and Stern, Y. (2008). Survival in Alzheimer disease: a multiethnic, population-based study of incident cases. Neurology, 71, 1489–1495.Google Scholar
Hier, D. B., Warach, J. D., Gorelick, P. B. and Thomas, J. (1989). Predictors of survival in clinically diagnosed Alzheimer's disease and multi-infarct dementia. Archives of Neurology, 46, 1213–1216.CrossRefGoogle ScholarPubMed
Hodges, J., Davies, R., Xuereb, J., Kril, J. and Halliday, G. (2003). Survival in frontotemporal dementia. Neurology, 61, 349–354.CrossRefGoogle ScholarPubMed
Hu, W. T. et al. (2007). Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia. Alzheimer Disease & Associated Disorders, 21, S39–S43.Google Scholar
Jagger, C., Clarke, M. and Stone, A. (1995). Predictors of survival with Alzheimer's disease: a community-based study. Psychological Medicine, 25, 171–177.Google Scholar
Jicha, G. A. et al. (2006). Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Archives of Neurology, 63, 674.Google Scholar
Jorm, A. (1990). The Epidemiology of Alzheimer's Disease and Related Disorders. London: Chapman and Hall.Google Scholar
Jost, B. C. and Grossberg, G. T. (1995). The natural history of Alzheimer's disease: a brain bank study. Journal of the American Geriatrics Society, 43, 1248–1255.CrossRefGoogle ScholarPubMed
Kay, D. W., Forster, D. P. and Newens, A. J. (2000). Long-term survival, place of death, and death certification in clinically diagnosed pre-senile dementia in northern England: follow-up after 8–12 years. British Journal of Psychiatry, 177, 156–162, Aug 2000.CrossRefGoogle ScholarPubMed
Keene, J., Hope, T., Fairburn, C. G. and Jacoby, R. (2001). Death and dementia. International Journal of Geriatric Psychiatry, 16, 969–974.CrossRefGoogle ScholarPubMed
Knopman, D. S., Rocca, W. A., Cha, R. H., Edland, S. D. and Kokmen, E. (2003). Survival study of vascular dementia in Rochester, Minnesota. Archives of Neurology, 60, 85–90.Google Scholar
Koedam, E. L. G. E. et al. (2008). Early-onset dementia is associated with higher mortality. Dementia & Geriatric Cognitive Disorders, 26, 147–152.CrossRefGoogle ScholarPubMed
Larson, E. B. et al. (2004). Survival after initial diagnosis of Alzheimer disease. [see comment]. Annals of Internal Medicine, 140, 501–509.CrossRefGoogle ScholarPubMed
Martin, D. C., Miller, J. K., Kapoor, W., Arena, V. C. and Boller, F. (1987). A controlled study of survival with dementia. Archives of Neurology, 44, 1122–1126.Google Scholar
Max Planck Insitute for Demographic Research, Department of Demography at the University of California and Institut national d'etudes demographiques (2007). The Human Life-Table Database. Max-Planck-Gesellschaft. Available at www.lifetable.de.Google Scholar
McGonigal, G., McQuade, C. A., Thomas, B. M. and Whalley, L. J. (1992). Survival in presenile Alzheimer's and multi-infarct dementias. Neuroepidemiology, 11, 121–126.Google Scholar
Mitchell, J., Arnold, R., Dawson, K., Nestor, P. J. and Hodges, J. R. (2009). Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm. Journal of Neurology, 256, 1500–1509.CrossRefGoogle ScholarPubMed
Molsa, P., Marttila, R. and Rinne, U. (1995). Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia. Acta Neurologica Scandinavica, 91, 159–164.CrossRefGoogle ScholarPubMed
Newens, A., Forster, D., Kay, D., Kirkup, W., Bates, D. and Edwardson, J. (1993). Clinically diagnosed presenile dementia of the Alzheimer type in the Northern Health Region: ascertainment, prevalence, incidence and survival. Psychological Medicine, 23, 631–644.Google Scholar
Olichney, J. M. et al. (1998). Cognitive decline is faster in Lewy body variant than in Alzheimer's disease. Neurology, 51, 351–357.Google Scholar
Rait, G., Walters, K., Bottomley, C., Petersen, I., Iliffe, S. and Nazareth, I. (2010). Survival of people with clinical diagnosis of dementia in primary care: cohort study. BMJ, 341, c3584. doi: 10.1136/bmj.c3584.Google Scholar
Reisberg, B., Ferris, S. H., Franssen, E. H. and Shulman, E. (1996). Mortality and temporal course of probable Alzheimer's disease: a 5-year prospective study. International Psychogeriatrics, 8, 291–311.Google Scholar
Roberson, E. D. et al. (2005). Frontotemporal dementia progresses to death faster than Alzheimer disease. Neurology, 65, 719–725.Google Scholar
Samson, W. N., van Duijn, C. M., Hop, W. C. and Hofman, A. (1996). Clinical features and mortality in patients with early-onset Alzheimer's disease. European Neurology, 36, 103–106.Google Scholar
Schoenberg, B. S., Kokmen, E. and Okazaki, H. (1987). Alzheimer's disease and other dementing illnesses in a defined United States population: incidence rates and clinical features. Annals of Neurology, 22, 724–729.Google Scholar
Smithurst, B. A. and Pozzi, E. (1988). Survival of patients in hospital with dementia. Singapore Medical Journal, 29, 74–75.Google ScholarPubMed
Tschanz, J. et al. (2004). Dementia: the leading predictor of death in a defined elderly population: the Cache County Study. Neurology, 62, 1156–1162.Google Scholar
Walker, Z., Allen, R. L., Shergill, S., Mullan, E. and Katona, C. L. (2000). Three years survival in patients with a clinical diagnosis of dementia with Lewy bodies. International Journal of Geriatric Psychiatry, 15, 267–273.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Walsh, J. S., Welch, H. G. and Larson, E. B. (1990). Survival of outpatients with Alzheimer-type dementia. Annals of Internal Medicine, 113, 429–434.CrossRefGoogle ScholarPubMed
Wang, L. Y. et al. (2009). Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample. Journal of Geriatric Psychiatry & Neurology, 22, 256–265.Google Scholar
Waring, S. C., Doody, R. S., Pavlik, V. N., Massman, P. J. and Chan, W. (2005). Survival among patients with dementia from a large multi-ethnic population. Alzheimer Disease & Associated Disorders, 19, 178–183.Google Scholar
Williams, M. M., Xiong, C., Morris, J. C. and Galvin, J. E. (2006). Survival and mortality differences between dementia with Lewy bodies vs. Alzheimer disease. Neurology, 67, 1935–1941.CrossRefGoogle ScholarPubMed
Wolfson, C. et al. (2001). A reevaluation of the duration of survival after the onset of dementia. The New England Journal of Medicine, 344, 1111–1116.Google Scholar
Wood, E., Whitfield, E. and Christie, A. (1991). Changes in survival in demented hospital inpatients 1957–1987. International Journal of Geriatric Psychiatry, 6, 523–528.CrossRefGoogle Scholar
Yaffe, K., Petersen, R. C., Lindquist, K., Kramer, J. and Miller, B. (2006). Subtype of mild cognitive impairment and progression to dementia and death. Dementia and Geriatric Cognitive Disorders, 22, 312–319.CrossRefGoogle ScholarPubMed
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