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Circadian Rhythm-Related Behavioral Disturbances and Structural Hypothalamic Changes in Alzheimer's Disease

Published online by Cambridge University Press:  07 January 2005

Witte J. G. Hoogendijk ,
Eus J. W. van Someren ,
Majid Mirmiran ,
Michel A. Hofman ,
Paul J. Lucassen ,
Jiang-Ning Zhou  and
Dick F. Swaab
Witte J. G. Hoogendijk
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands Valerius Clinic, Department of Psychiatry, Research Institute Neurosciences Free University, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Eus J. W. van Someren
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Majid Mirmiran
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Michel A. Hofman
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Paul J. Lucassen
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Jiang-Ning Zhou
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
Dick F. Swaab
Affiliation:
Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
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Extract

Age-related changes in circadian rhythm (e.g., fragmented sleep-wake patterns) occur in many older persons but are particularly pronounced in patients with Alzheimer's disease. In these patients, disruptions of circadian rhythms can be severe enough to increase mental decline, agitation during the day, and restlessness at night. Moreover, patients whose nocturnal restlessness disrupts the sleep of the caregiver are more likely to be institutionalized than those who have cognitive impairment alone.

Type
Etiology
Information
International Psychogeriatrics , Volume 8 , Issue S3 , May 1997 , pp. 245 - 252
Copyright
© 1996 International Psychogeriatric Association

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