A common “interdependence problematique” can be found in recent literature on security interdependence, regional integration processes, ecological limits to growth, and global political economy. Six problematical aspects of interdependence relationships should therefore be given definitional significance: existing or proposed transnational or intergovernmental relationships in the post-Cold War era typically raise issues concerning the degree of public consumption interdependence, the extent to which situational interests are non-zero sum, the need for coordinated production relationships, the extent of cross-sector or inter-functional interdependence and the vulnerabilities involved in breaking with or doing without any such institutionalized relationships. Twenty methodological maxims are useful for appraising the design relevance of empirical research on partial, regime-like world order alternatives. Much but not all previous research has been severely deficient in addressing the efficiency, equity, conservation, and feasibility implications of contending interdependence alternatives.