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Susceptibility of a Trypanosoma congolense Isolate of Water-Buffalo Origin to Diminazene Aceturate and Isometamidium Chloride
Published online by Cambridge University Press: 19 September 2011
Abstract
Laboratory mice infected with a Trypanosoma congolense isolate of water-buffalo origin did not respond when treated with diminazene aceturate (Berenil, Hoechst, West Germany) at 3.5 mg/kg and 7 mg/kg body weight (b.wt.) and also isometamidium chloride (Samorin, May & Baker, Dagenham, England) at doses less than 3 mg/kg b.wt. Effective cure was achieved with isometamidium and diminazene at 3 mg/kg and 14 mg/kg b.wt. respectively; doses in excess of those recommended for use in the field to treat animal trypanosomiasis by the manufacturers. Irregular use of the two drugs on infected water-buffaloes while improperly restrained may be one of the factors responsible for the dual drug resistant T. congolense isolate emerging.
Résumé
Des souris de laboratoire infectées par inoculation avec des isolats de Trypanosoma congolense prélevés sur des buffles n'ont pas réagi à un traitement à l'acéturate de diminazene (Bĕrénil, Hoechst, Rép. fed. d'Allemagne) dosé à 3,5 et 7 mg/kg de poids vif, ni á des doses de moins de 3 mg/kg de poids vif de chlorure d'isométamidium (Samorin, May & Baker, Dagenham, Angleterre). Pour obtenir une guérison, il a fallu employer des doses de 3 mg/kg de poids vif d'isométamidium et de 14 mg/kg de poids vif de diminazène. Ces doses excèdent celles recommandées par les fabricants pour traiter la trypanosomiase animale sur le terrain. L'usage irrégulier et mal contrôlé de ces deux produits pour le traitement de buffles infectés explique en partie l'émergence d'isolats de T. congolense résistants à ces deux médicaments.
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References
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