Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-28T19:32:31.791Z Has data issue: false hasContentIssue false
  • English
  • Français

Growth-Inhibitory Activity of 1-Benzyl-5[E]-2, 6-Dimethyl-1, 5-Heptadienyl Imidazole (KK-42) on Spodoptera litura

Published online by Cambridge University Press:  19 September 2011

Archana Kumari  and
H.C. Agarwal
Archana Kumari
Affiliation:
Department of Zoology, University of Delhi, Delhi-110 007, India
H.C. Agarwal
Affiliation:
Department of Zoology, University of Delhi, Delhi-110 007, India
Get access

Abstract

The ecdysteroid agonist KK-42 [l-benzyl-5(E)-2,6- dimethyl-1,5-heptadienyl] imidazole adversely affected the growth of Spodoptera litura and caused a delay in pupation. The compound also caused adult deformation, increased sex ratio in favour of males, and adversely affected the fecundity and fertility of emergent females. The ecdysteroid 20-hydroxyecdysone, identified by HPLC, was present in treated and control insects. Ecdysone was also detected in only the insects treated with 1 μg/larva KK-42.

Résumé

L'inhibiteur antagonique de la biosynthèses de l'ecdystéroide: le KK-42 [l-bénzyle-5(E)-2,6-diméthyle-l, 5 heptodiényle] imidazole affectait sérieusement la croissance et le développement de Spodoptera litura et retardait la chrysalidation. Cette substance provoquait également des malformations chez adultes et le décalage du sex ratio en faveur de l'augmentation du taux de mâles par rapport aux femelles. De même, le produit affectait négativement la fécondité et la fertilité des femelles émergées. L'ecdystéroide 20-hydroxyecdysone identifié par méthode HPCL, était trouvé tant chez les sujets traités que chez les témoins. De même, l'ecdysone était détectée seulement chez les insectes traités à la dose de 1 μg de KK-42 par larve.

Keywords

[1-benzyl-5[E]-26-dimethyl-15-heptadienyl] imidazoleSpodoptera lituraantiecdysteroidal activityKK-42[1-benzyle-5(E)-26-diméthyle-15 heptodiényle] imidazoleactivité anti-ecdystéroïdaleKK-42
Type
Research Articles
Information
International Journal of Tropical Insect Science , Volume 18 , Issue 4 , December 1998 , pp. 365 - 369
Copyright
Copyright © ICIPE 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Gelman, D. B., Bell, R. A., Demilo, A. B. and Kochansky, J. P. (1995) Effect of KK-42 on the growth, development, molting and metamorphosis of the European corn borer, Ostrinia nubilalis (Hubner). Arch. Insect. Biochem. Physiol. 28, 1–15.CrossRefGoogle Scholar
Kadono-Okuda, K., Kuwano, E., Eto, M. and Yamashita, O. (1987a) Anti-ecdysteroid action of some imidazole derivatives on pupal-adult development of the silkworm, Bombyx mori (Lepidoptera:Bombycidae). Appi. Ent. Zool. 22, 370–379.Google Scholar
Kadono-Okuda, K., Kuwano, E., Eto, M. and Yamashita, O. (1987b) Inhibitory action of an imidazole compound on ecdysone synthesis in prothoracic glands of the silkworm, Bombyx mori. Dev. Grow. Diff. 29, 527–533.Google Scholar
Koga, D., Funakoshi, T., Fujimoto Hv Kuwano, E., Eto, M. and Ide, A. (1991) Effects of 20-hydroxyecdysone and KK-42 on chitinase and beta-N-acetylglucosaminidase during the larval-pupal transformation of Bombyx mori. Insect Biochem. 21, 277–284.CrossRefGoogle Scholar
Kuthiala, A., Agarwal, H. C., Thompson, M. J. and Svoboda, J. A. (1987) 25-azasteroid inhibition of development and conversion of C28 and C29 phytosterols to cholesterol in Spodoptera litura (F.). Arch. Insect Biochem. Physiol. 4, 57–66.CrossRefGoogle Scholar
Kuwano, E., Takeya, R. and Eto, M. (1985) Synthesis and anti-juvenile hormone activity of 1-substituted-5-[(E)-2,6-dimethyl-1, 5-heptadienyl] imidazoles. Agrie. Biol. Chem. 49, 483–486.Google Scholar
Kuwano, E., Tanaka, Y., Kikuchi, M. and Eto, M. (1988) Effects of anti-juvenile hormones and related compounds on development in the larvae of Bombyx mori. J. Vac. Agr., Kyushu Univ. 33, 17–28.Google Scholar
Monroe, R. E. (1960) Effect of dietary cholesterol on house fly reproduction. Ann. Entomol. Soc. Am. 53, 821–824.CrossRefGoogle Scholar
Saxena, R. (1984) Sterol requirement, absorption, metabolism and the inhibitive effects of some compounds in Spodoptera litura (F.). PhD thesis submitted to University of Delhi for the Degree of Doctor of Philosophy.Google Scholar
Snedecor, G. W. and Cochran, W. G. (1970) Statistical Methods. The Iowa State Univ. Press, Ames.534 pp.Google Scholar
Thompson, M. J., Feldlaufer, M. F., Lozano, R., Rees, H. H., Lusby, W. R., Svoboda, J. A. and Wilzer, K. R. Jr (1987) Metabolism of 26-(14C)hydroxyecdysone26-phosphate in the tobacco hornworm, Manduca sexta to a new ecdysteroid conjugate: 26-(14C)hydroxyecdysone 22-glucoside. Arch. Insect Biochem. Physiol. 4, 1–15.Google Scholar
Thompson, M. J., Svoboda, J. A. and Weirich, G. F. (1984) Ecdysteroids in developing ovaries and eggs of the tobacco hornworm. Steroids 43, 333–342.Google Scholar