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Shift from first generation antipsychotics to olanzapine may improve health-related quality of life of stable but residually symptomatic schizophrenic outpatients: A prospective, randomized study

Published online by Cambridge University Press:  01 October 2008

Grigori Joffe ,
Harri Sintonen  and
Björn Appelberg
Grigori Joffe
Affiliation:
Helsinki University Central Hospital
Harri Sintonen
Affiliation:
University of Helsinki
Björn Appelberg
Affiliation:
Helsinki University and Helsinki University Central Hospital
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Abstract

Objectives: The aim of this study was to elucidate, whether shift from first generation antipsychotics (FGA) to olanzapine can affect health-related quality of life (HRQoL) of residually symptomatic schizophrenic outpatients.

Methods: Patients were randomized to either olanzapine or to continuation on their FGA. The 15D-measured HRQoL at baseline and end-point (after 12 weeks) was compared.

Results: Patients (n = 21) randomized to olanzapine achieved better HRQoL than those (n = 21) who continued on their FGA. This difference on the 15D (0.048 on a 0–1 scale; p = .037) was clinically important and comparable to that resulting from common surgical interventions, for example, hip or knee replacement.

Conclusions: HRQoL of stable outpatients with residual symptoms or adverse effects may improve substantially after shift from FGAs to olanzapine.

Keywords

SchizophreniaOlanzapineAtypical antipsychoticsConventional antipsychotics15D
Type
GENERAL ESSAYS
Information
International Journal of Technology Assessment in Health Care , Volume 24 , Issue 4 , October 2008 , pp. 399 - 402
Copyright
Copyright © Cambridge University Press 2008

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References

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