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Maternal Immunization to Prevent Infectious Diseases in the Neonate or Infant

Published online by Cambridge University Press:  14 October 2009

Richard A. Insel ,
Marvin Amstey ,
Kathleen Woodin  and
Michael Pichichero
Richard A. Insel
Affiliation:
University of Rochester Medical Center
Marvin Amstey
Affiliation:
University of Rochester Medical Center
Kathleen Woodin
Affiliation:
University of Rochester Medical Center
Michael Pichichero
Affiliation:
University of Rochester Medical Center
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Abstract

The approach of providing passive protection to young infants by immunizing pregnant women can bypass the problems of immunological immaturity in the neonate, avoid or delay active immunization of the infant in the first year of life, and prevent transmission of an infection from the mother to the neonate. Optimal vaccines for this approach should induce high immunoglobulin G antibody titers that quickly reach their maximum level after immunization and persist at protective levels for several years, thus providing passive protection in subsequent pregnancies. Specific applications of this approach include the worldwide practice of maternal immunization with tetanus toxoid vaccine and ongoing studies of maternal immunization to prevent Haemophilus influenzae type b, group B strepto-coccal, pneumococcal, meningococcal, and human immunodeficiency virus infection in the infant. Addressing the cultural, sociological, and legal aspects of maternal immunization will be required to ensure the success of this approach.

Type
Special Section: Vaccines and Public Health: Assessing Technologies and Public Policies
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 1 , Winter 1994 , pp. 143 - 153
Copyright
Copyright © Cambridge University Press 1994

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References

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