Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-25T05:12:51.614Z Has data issue: false hasContentIssue false
  • English
  • Français

Magnetic Resonance Spectroscopy Emerges as a Quantitative Diagnostic Tool and an Aid to Therapeutic Procedures

Published online by Cambridge University Press:  10 March 2009

Britton Chance  and
Roger Wheatley
Britton Chance
Affiliation:
Department of Biochemistry and BiophysicsUniversity of Pennsylvania
Roger Wheatley
Affiliation:
Phospho-Energetics, Inc. Philadelphia
Get access Rights & Permissions [Opens in a new window]

Extract

These new developments show the value of MR in studying a phase of metabolism hitherto unavailable, namely that of “preventive” study prior to significant lactate formation and surely prior to the cell damage edema and cell death so characteristic of stroke and heart disease. We believe that these approaches can be developed appropriately for clinical application and will thereby open a new type of diagnosis and therapy.

Type
An International View of Magnetic Resonance—Imaging and Spectroscopy
Information
International Journal of Technology Assessment in Health Care , Volume 1 , Issue 3 , July 1985 , pp. 607 - 613
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Chance, B., Eleff, S., Sokolow, D., & Sapega, A.Mitochondrial regulation of phos-phocreatine, phosphate ratios in exercised human muscle: A gated 31-P NMR study. Proceedings of the National Academy of Science, 1981, 78, 6714–18.CrossRefGoogle Scholar
2.Chance, B., Sapega, A., Sokolow, D., Eleff, S., Leigh, J. S. Jr, Graham, T., Armstrong, J., & Warnell, R. Fatigue in retrospect and prospect: 31-P NMR studies of exercise performance. In Knuttgen, H. G., Vogal, J. A., & Poortmans, J., (eds.), Biochemistry of Exercise (International Symposium in Sports Medicine, Vol. 13). Chicago, IL: Human Kinetics, 1983, 895–908.Google Scholar
3.Eleff, S., Kennaway, N. G., Buist, N. R. M., Darley-Usmar, V. M., Capaldi, R. A., Bank, W. J., & Chance, B.31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle. Proceedings of the National Academy of Science, 1984, 81, 3529–33.CrossRefGoogle Scholar
4.Gyulai, L., Roth, Z., Leigh, J. S. Jr, & Chance, B.Bioenergetic studies of mitochondrial oxidative phosphorylation by 31P NMR spectroscpy, 3rd Annual Meeting of the Society of Magnetic Resonance in Medicine, 1984, 285.Google Scholar
5.Gyulai, L., Bolinger, L., Leigh, J. S. Jr, Barlow, C., & Chance, B.Phosphoryle-thanolamine—the major constituent of the phosphomonoester peak observed by 31P NMR on developing dog brain. FEBS Letters, 1984, 178, 137–42.CrossRefGoogle ScholarPubMed
6.Hope, P. L., Cady, E. B., Tofts, P. S., Hamilton, P. A., Costello, A. M.de L., Delpy, D. T., Chu, A., Reynolds, E. O. R., & Wilkie, D. R.Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. The Lancet 1984, 08 18, 366–70.CrossRefGoogle Scholar
7.Maris, J. M., Evans, E. A., McLaughlin, A. C., D'Angio, G. H. J., Bolinger, L., Manos, H., & Chance, B.31P Nuclear magnetic resonance spectroscopic investigation of human neuroblastoma in situ. New England Journal of Medicine. In press.Google Scholar
8.Whitman, G. J., Chance, B., Bode, H., Maris, J., Haselgrove, J., Kelley, R., Clark, B. J., & Harken, A.Diagnosis and therapeutic evaluation of a pediatric cardiomyopathy using 31P NMR. Journal of the American College of Cardiology, in press.Google Scholar
9.Younkin, D. P., Delivoria-Papadopoulos, M., Leonard, J. C., Subramanian, V.Harihara, Eleff, S., Leigh, J. S. Jr, & Chance, B.Unique aspects of human newborn cerebral metabolism evaluated with phosphorus nuclear magnetic resonance spectroscopy. Annals of Neurology, 1984, 15, 581–86.CrossRefGoogle Scholar