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Effective Mucosal Immunity: Current Concepts for Vaccine Delivery and Immune Response Analysis

Published online by Cambridge University Press:  14 October 2009

Jerry R. McGhee
Affiliation:
University of Alabama at Birmingham
Hiroshi Kiyono
Affiliation:
University of Alabama at Birmingham

Abstract

It is now established that the mucosal immune system is a separate entity and is regulated in a different fashion than that in peripheral lymphoid tissues (the systemic immune system). In this brief review, five selected areas within the field of mucosal immunity are discussed in the context of the goals for vaccines for the Children's Vaccine Initiative.

Type
Special Section: Vaccines and Public Health: Assessing Technologies and Public Policies
Copyright
Copyright © Cambridge University Press 1994

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References

REFERENCES

1.Abraham, E., & Robinson, A.Oral administration with bacterial polysaccharide and adjuvant enhances antigen-specific pulmonary secretory antibody response and resistance to pneumonia. Vaccine, 9, 1991, 757–64.CrossRefGoogle ScholarPubMed
2.Babb, J. L., Kiyono, H., Michalek, S. M., et al. LPS regulation of the immune response: Suppression of immune response to orally-administered T-independent antigen. Journal of Immunology, 1981, 27, 1052–57.CrossRefGoogle Scholar
3.Berek, C., Berger, A., & Apel, M.Maturation of the immune response in germinal centers. Cell, 1991, 67, 1121–29.CrossRefGoogle ScholarPubMed
4.Blier, P., & Bothwell, A.A limited number of B cell lineages generates the heterogeneity of a secondary immune responses. Journal of Immunology, 1987, 139, 39964006.CrossRefGoogle Scholar
5.Bockman, D. E., & Cooper, M. D.Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix and Peyer's patches: An electron microscopic study. American Journal of Anatomy, 1973, 136, 455–77.CrossRefGoogle ScholarPubMed
6.Brandtzaeg, P. Immune functions of human nasal mucosa and tonsils in health and disease. In Bienenstock, J. (ed.), Immunology of the lung and upper respiratory tract. New York: McGraw-Hill Book Co., 28–95.Google Scholar
7.Brandtzaeg, P. Distribution and characteristics of mucosal immunoglobulin-producing cells. In Ogra, P. L, et al. (eds.), Mucosal immunology. Academic Press, in press.Google Scholar
8.Brandtzaeg, P., & Bjerke, K.Immunomorphological characteristics of human Peyer's patches. Digestion, 1990, 46: 262–73.CrossRefGoogle ScholarPubMed
9.Brown, T. A., & Mestecky, J.Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigens. Infection and Immunity, 1988, 49, 459–62.CrossRefGoogle Scholar
10.Butcher, E. C., Rouse, R. V., Coffman, R. L., et al. Surface phenotype of Peyer's patch germinal center cells: Implications for the role of germinal centers in B cell differentiation. Journal of Immunology, 1982, 129, 2698–707.CrossRefGoogle ScholarPubMed
11.Conley, M. E., & Delacroix, D. L.Intravascular and mucosal immunoglobulin A: Two separate but related systems of immune defense? Annals of Internal Medicine, 1987, 106, 892–99.CrossRefGoogle ScholarPubMed
12.Delacroix, D. L., Hodgson, H. J. F., McPherson, A., et al. Selective transport of polymeric IgA in bile: Quantitative relationships of monomeric and polymeric IgA, IgM and other proteins in serum, bile and saliva. Journal of Clinical Investigation, 1991, 88, 230–41.Google Scholar
13.Fujihashi, K., McGhee, J. R., Lue, C., et al. Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgAl and IgA2 synthesis. Journal of Clinical Investigation, 1991, 88, 248–52.CrossRefGoogle Scholar
14.Hammarstrom, L., & Smith, C. I. E.IgG subclass changes in response to vaccination. Monographs in Allergy, 1986, 19, 241–52.Google ScholarPubMed
15.Hanson, L. A., & Brandtzaeg, P. The mucosal defense system. In Stiehm, E. R. (ed.), Immunologic disorders in infants and children. Philadelphia, PA: W. B. Saunders, Co., 1989, 116–55.Google Scholar
16.Inman, L., & Cantey, J.Specific adherence of Escherichia coli (strain RDEC -1) to membranous M cells of the Peyer's patch in Escherichia coli diarrhea in the rabbit. Journal of Clinical Investigation, 1983, 71, 18.CrossRefGoogle ScholarPubMed
17.Jacob, J., Kelsoe, G., Rajewsky, K., et al. Intraclonal generation of antibody mutants in germinal centres. Nature, 1991, 354, 389–92.CrossRefGoogle ScholarPubMed
18.Kett, K., Brandtzaeg, P., Radl, J., et al. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. Journal of Immunology, 1986, 136, 3631–35.CrossRefGoogle ScholarPubMed
19.Kiyono, H., Bienenstock, J., McGhee, J. R., et al. The mucosal immune system: Features of inductive and effector sites to consider in mucosal immunization and vaccine development. Regional Immunology, 1992, 4, 5462.Google ScholarPubMed
20.Krall, W. J., & Braun, J.In vivo retroviral marking of antigen-specific B lymphocytes. Seminars in Immunology, 1992, 4, 1928.Google ScholarPubMed
21.Kuper, C. F., Koornstra, P. J., Hameleers, D. M. H., et al. The role of nasopharyngeal lymphoid tissue. Immunology Today, 1991, 12, 219–24.Google Scholar
22.Liu, Y.-J., Johnson, G. D., Gordon, J., et al. Germinal centres in T-cell-dependent antibody responses. Immunology Today, 1992, 13, 1721.CrossRefGoogle ScholarPubMed
23.Lycke, N., Hellstrom, U., & Holmgren, J.Circulating cholera antitoxin memory cells in the blood one year after oral cholera vaccination in humans. Scandinavian Journal of Immunology, 1987, 26, 207–11.CrossRefGoogle ScholarPubMed
24.Lycke, N., & Holmgren, J.Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin. Scandinavian Journal of Immunology, 1986, 23, 611–16.CrossRefGoogle ScholarPubMed
25.Lycke, N., & Holmgren, J.Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization. Scandinavian Journal of Immunology, 1987, 25, 407–12.CrossRefGoogle ScholarPubMed
26.Lycke, N., and Holmgren, J.Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin. Infection and Immunity, 1989, 57, 1137–41.CrossRefGoogle ScholarPubMed
27.Mayer, L., & Shlien, R.Evidence for function of la molecules on gut epithelial cells in man. Journal of Experimental Medicine, 1987, 166, 1471–83.CrossRefGoogle Scholar
28.McGhee, J. R., Mestecky, J., Dertzbaugh, M. T., et al. The mucosal immune system: From fundamental concepts to vaccine development. Vaccine, 1992, 10, 7588.CrossRefGoogle ScholarPubMed
29.Mega, J., McGhee, J. R., & Kiyono, H.Cytokine and Ig-producing cells in mucosal effector tissues: Analysis of IL-5- and IFN-y producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues. Journal of Immunology, 1992, 148, 2030–39.CrossRefGoogle Scholar
30.Mestecky, J.The common mucosal immune system and current strategies for induction of immune responses in external secretions. Journal of Clinical Immunology, 1987, 7, 265–76.CrossRefGoogle ScholarPubMed
31.Mestecky, J., Lue, C., & Russell, M. W.Selective transport of IgA: Cellular and molecular aspects. Gastroenterology Clinics of North America, 1991, 20, 441–71.CrossRefGoogle ScholarPubMed
32.Mestecky, J., & McGhee, J. R.Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. Advances in Immunology, 1987, 40, 153245.CrossRefGoogle ScholarPubMed
33.Mestecky, J., & Russell, M.W.IgA subclasses. Monographs in Allergy, 1986, 19, 277301.Google ScholarPubMed
34.Michetti, P., Mahan, M. J., Slauch, J. M., et al. Monoclonal secretory IgA protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infection and Immunity, 1992, 60, 1786–92.CrossRefGoogle ScholarPubMed
35.Mongini, P. K. A., Paul, W. E., & Metcalf, E. S.IgG subclass, IgE and IgA antitrinitrophenyl antibody production within trinitrophenyl-ficoll-responsive B cell clones. Evidence in support of three distinct switching pathways. Journal of Experimental Medicine, 1983, 157, 6985.CrossRefGoogle ScholarPubMed
36.Mosmann, T. R., & Coffman, R. L.Two types of mouse helper T-cell clone. Immunology Today, 1987, 8, 223–27.CrossRefGoogle ScholarPubMed
37.Mosmann, T. R., & Coffman, R. L.Thl and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology, 1989, 7, 145–73.CrossRefGoogle Scholar
38.Owens, R. L., & Jones, A. L.Epithelial cell specialization within human Peyer's patches: An ultrastructural study of intestinal lymphoid follicles. Gastroenterology, 1974, 66, 189203.CrossRefGoogle Scholar
39.Street, N. E., & Mosmann, T. R.Functional diversity of T lymphocytes due to secretion of different cytokines patterns. FASEB Journal, 1991, 5, 171–77.CrossRefGoogle Scholar
40.Taguchi, T., McGhee, J. R., Coffman, R. L., et al. Analysis of Thl and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-y and IL-5. Journal of Immunology, 1990, 145, 6877.CrossRefGoogle Scholar
41.Winner, L., Mack, J., Weltzin, R., et al. New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infection and Immunology, 1991, 59, 977–82.CrossRefGoogle ScholarPubMed
42.Wolf, J. L., Rubin, D. H., Finberg, R., et al. Intestinal M cells: A pathway for entry of reovirus into the host. Science, 1981, 212, 471–72.CrossRefGoogle ScholarPubMed
43. Xu-Amano, J., Aicher, W. K., Taguchi, T., et al. Selective induction of Th2 cells in murine Peyer's patches by oral immunization. International Immunology, 1992, 4, 433–45.CrossRefGoogle Scholar
44.Xu-Amano, J., Fujihashi, K., Jackson, R., et al. Mucosal vaccine and Thl/Th2 responses. Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa-associated tissues. Journal of Experimental Medicine, 1993, 178, 1309–20.CrossRefGoogle Scholar
45.Xu-Amano, J., Fujihashi, K., Jackson, R. J., et al. Effect of cholera toxin on induction of Thl and Th2 responses in mucosa-associated tissues. Manuscript submitted for publication.Google Scholar