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Assessment of Screening Tests for Transfusion-Associated Non-A Non-B Hepatitis

Published online by Cambridge University Press:  10 March 2009

Frederic Fleurette ,
Pierre Durieux ,
Renaldo N. Battista ,
Jean-Pierre Benhamou ,
Françoise Degos ,
Christian Brechot ,
Anne-Marie Courouce ,
Christian Janot  and
Christian Trepo
Frederic Fleurette
Affiliation:
Agence Nationale pour le Développement de l'Evaluation Medicate, Paris
Pierre Durieux
Affiliation:
Agence Nationale pour le Développement de l'Evaluation Medicate, Paris
Renaldo N. Battista
Affiliation:
Montreal General Hospital, Montreal
Jean-Pierre Benhamou
Affiliation:
Hopital Beaujon, Clichy
Françoise Degos
Affiliation:
Hopital Beaujon, Clichy
Christian Brechot
Affiliation:
CHU Necker Enfants Malades, Paris
Anne-Marie Courouce
Affiliation:
Institut National de Transfusion Sanguine, Paris
Christian Janot
Affiliation:
CRTS, Vandoeuvre les Nancy
Christian Trepo
Affiliation:
Hôtel Dieu, Lyon
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Abstract

Non-A non-B hepatitis is the most common serious sequela of blood transfusion, and its screening has become an essential goal of blood transfusion centers. Before 1989, two surrogate screening tests (for alanine aminotransferase and for antibody to hepatitis B core antigen) were used; in 1989, a direct test for the antibody to hepatitis C virus (the main agent of this hepatitis) was developed. The French National Agency for the Development of Medical Evaluation undertook an investigation to determine the optimal prevention strategy for posttransfusion non-A and non-B hepatitis (PTH). A detailed literature review was performed, complemented by expert group opinion. The performance of each test was derived indirectly by calculating the number of cases of PTH averted by each test. Hepatitis C virus testing is probably the most promising strategy, but different policies can be developed given the uncertainties of scientific data. Cost considerations should be taken into account in identifying the best screening strategy.

Type
General Essays
Information
International Journal of Technology Assessment in Health Care , Volume 9 , Issue 4 , Fall 1993 , pp. 479 - 489
Copyright
Copyright © Cambridge University Press 1993

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