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DNA Technology and Vaccines

Published online by Cambridge University Press:  10 March 2009

Fred Brown
Fred Brown
Affiliation:
U.S. Department of Agriculture
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Abstract

It has been 20 years since the concepts that are now embraced in the term recombinant DNA technology were first described. The technology has been used to design new vaccines, and one product — that for hepatitis B — has been in widespread use for almost a decade. Several other engineered vaccines have shown considerable promise in laboratory trials. Nevertheless, the potential of the approach is still to be realized. This article describes the principles that are involved in the design of these new vaccines, focusing on those for hepatitis B and rabies.

Type
Special Section: Genetic Technology
Information
International Journal of Technology Assessment in Health Care , Volume 10 , Issue 4 , Fall 1994 , pp. 583 - 591
Copyright
Copyright © Cambridge University Press 1994

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References

REFERENCES

1.Almond, J. W., & Burke, K. L.Poliovirus as a vector for the presentation of foreign antigens. Seminars in Virology, 1990, 1, 11–20.Google Scholar
2.Behring, E., & Kitasato, S.Ueber das Zustandekommen der Diphtherie-immunitat und Tetanus immunitat bei Tieren. Deutsche Medizinische Wochenschrift, 1890,16,1113–14.Google Scholar
3.Bloom, B. R., Snapper, S. B., Kieser, T., & Jacobs, W. R.Development of recombinant BCG vaccines. Seminars in Virology, 1990, 1, 21–27.Google Scholar
4.Brown, F.Synthetic viral vaccines. Annual Review of Microbiology, 1984, 38, 221–35.CrossRefGoogle ScholarPubMed
5.Brown, F.The potential of peptides as vaccines. Seminars in Virology, 1990, 1, 67–74.Google Scholar
6.Dougan, G., & Tite, J.Live bacterial vaccines for delivering antigens to the mammalian immune system. Seminars in Virology, 1990, 1, 29–37.Google Scholar
7.Francki, R. I. B., Fauquet, C. M., Knudson, D. L., & Brown, F. Classification and nomenclature of viruses. Archives of Virology, 1991, Supplementum, 2.CrossRefGoogle Scholar
8.Glenny, A. T. & Hopkins, B. E.Diphtheria toxoid as an immunising agent. British Journal of Experimental Pathology, 1923, 4, 283–88.Google Scholar
9.Graham, F. L. & Prevec, L. Adenovirus-based expression vectors and recombinant vaccines. In Ellis, R. W. (ed.), Vaccines: New approaches to immunological problems. Boston, MA: Butterworth-Heinemann, 1992, 363–90.CrossRefGoogle Scholar
10.Jenner, E.An inquiry into the causes and effects of the variolae vaccinae, a disease discovered in some of the western counties of England, particularly Gloucestershire and known by the name of smallpox. London: Samson Low, 1798.Google Scholar
11.Kit, M.Kit, S.Little, S. et al. Bovine herpesvirus-1 (infectious bovine rhinotracheitis virus)-based viral vector which expresses foot-and-mouth disease epitopes. Vaccine, 1991, 9, 564–72.CrossRefGoogle ScholarPubMed
12.Mackett, M.Vaccinia virus as a vector for delivering foreign antigens. Seminars in Virology, 1990, 1, 39–47.Google Scholar
13.Matsuura, Y.Possee, R. D.Overton, H. A. & Bishop, D. H. L.Baculovirus expression vectors: The requirements for high level expression of proteins, including glycoproteins. Journal of General Virology, 1987, 68, 1233–50.CrossRefGoogle ScholarPubMed
14.Morein, B.Fossum, C.Lovgren, K. & Hoglund, S.The iscom—A modern approach to vaccines. Seminars in Virology, 1990, 1, 49–55.Google Scholar
15.Naked DNA points way to vaccines. Research News, Science, 1993, 259, 1691–92.CrossRefGoogle Scholar
16.Racaniello, V. R. & Baltimore, D.Cloned poliovirus complementary DNA is infectious in mammalian cells. Science, 1981, 214, 916–19.CrossRefGoogle ScholarPubMed
17.Ramon, G.Sur le pouvoir floculant et sur les proprietes immunisantes d'une toxin diphterique rendue anatoxique (anatoxine). Comptes Rendus Academie Science, 1923, 177, 1338–40.Google Scholar
18.Ramon, G. & Zoeller, C.L'anatoxine tetanique et l'immunisation active de I'homme vis-à-vis du tetanus Annales de I'Institut Pasteur, 1927, 41, 803–33.Google Scholar
19.Ulmer, J. B.Donnelly, J. J. & Parker, S. E. et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science, 1993, 259, 1745–49.CrossRefGoogle ScholarPubMed
20.Valenzuela, P.Medina, A.Rutter, W. J. et al. Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature, 1983, 298, 347–50.CrossRefGoogle Scholar
21.Yilma, T.Hsu, D.Jones, L. et al. Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science, 1988, 242, 1058–61.CrossRefGoogle ScholarPubMed