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Viral whole-genome sequencing to assess impact of universal masking on SARS-CoV-2 transmission among pediatric healthcare workers

Published online by Cambridge University Press:  01 October 2021

Larry K. Kociolek Open the ORCID record for Larry K. Kociolek [Opens in a new window] ,
Ami B. Patel ,
Judd F. Hultquist ,
Egon A. Ozer ,
Lacy M. Simons ,
Matthew McHugh ,
William J. Muller  and
Ramon Lorenzo-Redondo
Larry K. Kociolek*
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
Ami B. Patel
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
Judd F. Hultquist
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois
Egon A. Ozer
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois
Lacy M. Simons
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois
Matthew McHugh
Affiliation:
Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
William J. Muller
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois
Ramon Lorenzo-Redondo
Affiliation:
Northwestern University Feinberg School of Medicine, Chicago, Illinois
*
Author for correspondence: Larry K. Kociolek, E-mail: [email protected]
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Abstract

Objective:

To identify the impact of universal masking on COVID-19 incidence and putative SARS-CoV-2 transmissions events among children’s hospital healthcare workers (HCWs).

Design:

Quasi-experimental study.

Setting:

Single academic free-standing children’s hospital.

Methods:

We performed whole-genome sequencing of SARS-CoV-2- PCR-positive samples collected from HCWs 3 weeks before and 6 weeks after implementing a universal masking policy. Phylogenetic analyses were performed to identify clusters of clonally related SARS-CoV-2 indicative of putative transmission events. We measured COVID-19 incidence, SARS-CoV-2 test positivity rates, and frequency of putative transmission events before and after the masking policy was implemented.

Results:

HCW COVID-19 incidence and test positivity declined from 14.3 to 4.3 cases per week, and from 18.4% to 9.0%, respectively. Putative transmission events were only identified prior to universal masking.

Conclusions:

A universal masking policy was associated with reductions in HCW COVID-19 infections and occupational acquisition of SARS-CoV-2.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 43 , Issue 10 , October 2022 , pp. 1408 - 1412
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Seidelman, JL, Lewis, SS, Advani, SD, et al. Universal masking is an effective strategy to flatten the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) healthcare worker epidemiologic curve. Infect Control Hosp Epidemiol 2020;41:1466–1467.CrossRefGoogle ScholarPubMed
Wang, X, Ferro, EG, Zhou, G, Hashimoto, D, Bhatt, DL. Association between universal masking in a health care system and SARS-CoV-2 positivity among healthcare workers. JAMA 2020;324:703–704.Google Scholar
Furukawa, NW, Brooks, JT, Sobel, J. Evidence supporting transmission of severe acute respiratory syndrome coronavirus 2 while presymptomatic or asymptomatic. Emerg Infect Dis 2020;26(7):e201595.CrossRefGoogle ScholarPubMed
Sung, AD, Sung, JAM, Thomas, S, et al. Universal mask usage for reduction of respiratory viral infections after stem cell transplant: a prospective trial. Clin Infect Dis 2016;63:999–1006.Google ScholarPubMed
Tong, WY, Yung, CF, Chiew, LC, et al. Universal face masking reduces respiratory viral infections among inpatient very-low-birthweight neonatal infants. Clin Infect Dis 2020;71:2958–2961.CrossRefGoogle ScholarPubMed
Chu, DK, Akl, EA, Duda, S, Solo, K, Yaacoub, S, Schünemann, HJ. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020;395:1973–1987.Google ScholarPubMed
Gandhi, M, Beyrer, C, Goosby, E. Masks do more than protect others during COVID-19: reducing the inoculum of SARS-CoV-2 to protect the wearer. J Gen Intern Med 2020;35:3063–3066.CrossRefGoogle ScholarPubMed
Fletcher, JJ, Feucht, EC, Hahn, PY, et al. Healthcare acquired COVID-19 is less symptomatic than community acquired disease among healthcare workers. Infect Control Hosp Epidemiol 2021. doi: 10.1017/ice.2021.167.Google ScholarPubMed
Hou, YJ, Chiba, S, Halfmann, P, et al. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science 2020;370:1464–1468.CrossRefGoogle ScholarPubMed
Plante, JA, Liu, Y, Liu, J, et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature 2021;592:116–121.CrossRefGoogle ScholarPubMed
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