Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-09T15:49:05.571Z Has data issue: false hasContentIssue false
  • English
  • Français

Usefulness of Molecular Epidemiology for Outbreak Investigations

Published online by Cambridge University Press:  02 January 2015

William R. Jarvis
William R. Jarvis*
Affiliation:
Investigation and Prevention Branch, Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia
*
Hospital Infections Program, MailstopA-07, Centers for Disease Control and Prevention, 1600 Clifton Rd. NW, Atlanta, GA 30333
Get access Rights & Permissions [Opens in a new window]

Abstract

We conducted a retrospective review of nosocomial outbreak investigations conducted by the Hospital Infections Program, Centers for Disease Control and Prevention, from January 1991 through March 1994. Selected outbreaks have demonstrated the utility of molecular methods such as plasmid analysis, plasmid restriction endonuclease analysis, ribotyping, restriction fragment polymorphism, pulsed-field gel electrophoresis, and polymerase chain reaction in confirming the clonality of the outbreak and in confirming the source of the outbreak implicated in the epidemiologic investigation. These data show that molecular typing of isolates is particularly useful when combined with epidemiologic investigations of nosocomial outbreaks.

Type
From the Third International Conference on the Prevention of Infection
Information
Infection Control & Hospital Epidemiology , Volume 15 , Issue 7 , July 1994 , pp. 500 - 503
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Haley, RW, Tenney, JH, Lindsey, JO II. Garner, JS, Bennett, JV. How frequent are outbreaks of nosocomial infection in community hospitals? Infect Control 1985:6:233–236.Google Scholar
2. Jarvis, WR, The Epidemiology Branch. Nosocomial outbreaks: the Centers for Disease Control Hospital Infections Program experience, 1980-1990. Am J Med 1991;91:101S–106S.Google Scholar
3. Aber, RC, Mackel, DC. Epidemiologic typing of nosocomial microorganisms. Am J Med 1981;70:899–902.Google Scholar
4. McGowan, JE Jr Weinstein, RA. The Role of the Laboratory in Control of Nosocomial Infection. In: Bennett, JV and Brachman, PS, ed. Hospital Injections. 3rd ed. Boston, MA: Little, Brown & Co; 1992:187–220.Google Scholar
5. Rosenblum, LS, Villarino, ME, Nainan, OV, et al. Hepatitis A outbreak in a neonatal intensive care unit: risk factors for transmission and evidence of prolongedviral excretion among preterm infants. J Infect Dis 1991;164:476–482.Google Scholar
6. Panlilio, AL, Beck-Sague, CM, Siegel, JD, et al. Infections and pseudoinfections due to povidone-iodine solution contaminated with Pseudomonas cepacia . Clin Infect Dis 1992;14:1078–1083.CrossRefGoogle ScholarPubMed
7. Beck-Sague, CM, Dooley, SW, Hutton, MD, et al. Hospital outbreak of multidrug-resistant Mycobacterium tuberculosis infections: factors in transmission to staff and HIV-infected patients. JAMA 1992;268:1280–1286.Google Scholar
8. Pearson, ML, Pegues, DA, Carson, LA, et al. Cluster of Enterobacter cloacae pseudobacteremias associated with use of an agar slant blood culturing system.] Clin Microbial 1993;31:2599–2603.Google Scholar
9. Postsurgical infections associated with an extrinsically contaminated intravenous anesthetic agent. MMWR 1990;39:426–433.Google Scholar
10. Edlin, BR, Tokars, JI, Grieco, MH, et al. An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome: epidemiologic studies and restriction fragment polymorphism analysis. N Eng J Med 1992;326:1514–1522.Google Scholar
11. Pearson, ML, Jereb, JA, Frieden, TR, Crawford, JT, Davis, B, Dooley, SW, Jarvis, WR. Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis: a risk to hospitalized patients and health care workers. Ann Intern Med 1992;117:191–196.Google Scholar
12. Coronado, VG, Beck-Sague, CM, Hutton, MD, et al. Transmission of multidrug-resistant Mycobacterium tuberculosis among patients with human immunodeficiency virus infection in an urban hospital: epidemiologic and restriction fragment polymorphism analysis. J Infect Dis 1993;168:1052–1055.Google Scholar
13. Maloney, S, Welbel, S, Daves, B, et al. Mycobacterium abscessus pseudoinfection traced to an automated endoscope washer: utility of epidemiologic and laboratory investigation. J Infect Dis 1994;169:1166–1169.Google Scholar
14. Welbel, SF, McNeil, MM. Pramanik, A, et al. Nosocomial Malassezia pachydermatis bloodstream infections in a neonatal intensive care unit. Pediatr Infect Dis J 1994;13:104–109.Google Scholar