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Subsequent carbapenem-resistant Enterobacteriaceae (CRE)–associated infections among hospitalized patients with CRE colonization: Impact of antibiotic use and other factors

Published online by Cambridge University Press:  01 June 2020

Thana Khawcharoenporn*
Affiliation:
Division of Infectious Diseases, Thammasat University, Pathumthani, Thailand
Wipada Laichuthai
Affiliation:
Department of Internal Medicine, Thammasat University, Pathumthani, Thailand
*
Author for correspondence: Thana Khawcharoenporn, E-mail: [email protected]

Abstract

We demonstrated a 20% rate of subsequent carbapenem-resistant Enterobacteriaceae (CRE)–associated infections among hospitalized CRE carriers. Independent factors associated with the infections were number of colonization sites, central-line insertion, and receiving vancomycin before colonization. These findings underscore the importance of antibiotic stewardship and device-related infection control measures to prevent CRE infections.

Type
Concise Communication
Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

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Footnotes

PREVIOUS PRESENTATION. Parts of this study were presented as a poster at IDWeek 2019 on October 3rd, 2019, in Washington, DC.

References

Logan, LK, Weinstein, RA. The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace. J Infect Dis 2017;215:S28S36.CrossRefGoogle ScholarPubMed
Dickstein, Y, Edelman, R, Dror, T, Hussein, K, Bar-Lavie, Y, Paul, M. Carbapenem-resistant Enterobacteriaceae colonization and infection in critically ill patients: a retrospective matched cohort comparison with non-carriers. J Hosp Infect 2016;94:5459.CrossRefGoogle ScholarPubMed
Schechner, V, Kotlovsky, T, Kazma, M, et al.Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect 2013;19:451456.CrossRefGoogle ScholarPubMed
Borer, A, Saidel-Odes, L, Eskira, S, et al.Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K. pneumoniae. Am J Infect Control 2012;40:421425.CrossRefGoogle ScholarPubMed
Giannella, M, Trecarichi, EM, De Rosa, FG, et al.Risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection among rectal carriers: a prospective observational multicentre study. Clin Microbiol Infect 2014;20:13571362.CrossRefGoogle ScholarPubMed
Zhang, L, Zhai, W, Lin, Q, et al.Carbapenem-resistant Enterobacteriaceae in hematological patients: outcome of patients with carbapenem-resistant Enterobacteriaceae infection and risk factors for progression to infection after rectal colonization. Int J Antimicrob Agents 2019;54:527529.CrossRefGoogle ScholarPubMed
Correa, AAF, Fortaleza, CMCB. Incidence and predictors of healthcare-associated infections among patients colonized with carbapenem-resistant Enterobacteriaceae. Am J Infect Control 2019;47:213216.CrossRefGoogle ScholarPubMed
Grice, EA, Segre, JA. The skin microbiome. Nat Rev Microbiol 2011;9:244253.CrossRefGoogle ScholarPubMed
Zimmerman, FS, Assous, MV, Bdolah-Abram, T, Lachish, T, Yinnon, AM, Wiener-Well, Y. Duration of carriage of carbapenem-resistant Enterobacteriaceae following hospital discharge. Am J Infect Control 2013;41:190194.CrossRefGoogle ScholarPubMed
Haverkate, MR, Weiner, S, Lolans, K, et al.Duration of colonization with Klebsiella pneumoniae carbapenemase-producing bacteria at long-term acute-care hospitals in Chicago, Illinois. Open Forum Infect Dis 2016;3:ofw178.CrossRefGoogle ScholarPubMed
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