Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-28T06:40:30.520Z Has data issue: false hasContentIssue false

Strategies to Prevent Central Line–Associated Bloodstream Infections in Acute Care Hospitals

Published online by Cambridge University Press:  02 January 2015

Jonas Marschall
Affiliation:
Washington University School of Medicine, St. Louis, Missouri
Leonard A. Mermel
Affiliation:
Warren Alpert Medical School of Brown Universityand Rhode Island Hospital, Providence, Rhode Island
David Classen
Affiliation:
University of Utah, Salt Lake City
Kathleen M. Arias
Affiliation:
Association for Professionals in Infection Control and Epidemiology, Washington, D.C.
Kelly Podgorny
Affiliation:
Joint Commission, Oakbrook Terrace, Chicago
Deverick J. Anderson
Affiliation:
Duke University Medical Center, Durham, North Carolina
Helen Burstin
Affiliation:
National Quality Forum, Washington, D.C.
David P. Calfee
Affiliation:
Mount Sinai School of Medicine, New York, New York
Susan E. Coffin
Affiliation:
Children's Hospital of Philadelphia and, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Erik R. Dubberke
Affiliation:
Washington University School of Medicine, St. Louis, Missouri
Victoria Fraser
Affiliation:
Washington University School of Medicine, St. Louis, Missouri
Dale N. Gerding
Affiliation:
Loyola University Chicago Stritch School of Medicine, Chicago Hines Veterans Affairs Medical Center, Hines, Illinois
Frances A. Griffin
Affiliation:
Institute for Healthcare Improvement, Cambridge
Peter Gross
Affiliation:
Hackensack University Medical Center, Hackensack, New Jersey University of Medicine and Dentistry–New Jersey Medical School, Newark, New Jersey
Keith S. Kaye
Affiliation:
Duke University Medical Center, Durham, North Carolina
Michael Klompas
Affiliation:
Brigham and Women's Hospitaland Harvard Medical School, Boston, Massachusetts
Evelyn Lo
Affiliation:
University of Manitoba, Winnipeg, Canada
Lindsay Nicolle
Affiliation:
University of Manitoba, Winnipeg, Canada
David A. Pegues
Affiliation:
David Geffen School of Medicine at the University of California, Los Angeles
Trish M. Perl
Affiliation:
Johns Hopkins Medical Institutions and University, Baltimore, Maryland
Sanjay Saint
Affiliation:
Ann Arbor Veterans Affairs Medical Center and theUniversity of Michigan Medical School, Ann Arbor, Michigan
Cassandra D. Salgado
Affiliation:
Medical University of South Carolina, Charleston
Robert A. Weinstein
Affiliation:
Stroger (Cook County) Hospital andRush University Medical Center, Chicago
Robert Wise
Affiliation:
Joint Commission, Oakbrook Terrace, Chicago
Deborah S. Yokoe
Affiliation:
Brigham and Women's Hospitaland Harvard Medical School, Boston, Massachusetts

Extract

Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical recommendations in a concise format designed to assist acute care hospitals in implementing and prioritizing their central line–associated bloodstream infection (CLABSI) prevention efforts. Refer to the Society for Healthcare Epidemiology of America/Infectious Diseases Society of America “Compendium of Strategies to Prevent Healthcare-Associated Infections” Executive Summary and Introduction and accompanying editorial for additional discussion.

1. Patients at risk for CLABSIs in acute care facilities

a. Intensive care unit (ICU) population: The risk of CLABSI in ICU patients is high. Reasons for this include the frequent insertion of multiple catheters, the use of specific types of catheters that are almost exclusively inserted in ICU patients and associated with substantial risk (eg, arterial catheters), and the fact that catheters are frequently placed in emergency circumstances, repeatedly accessed each day, and often needed for extended periods.

b. Non-ICU population: Although the primary focus of attention over the past 2 decades has been the ICU setting, recent data suggest that the greatest numbers of patients with central lines are in hospital units outside the ICU, where there is a substantial risk of CLABSI.

2. Outcomes associated with hospital-acquired CLABSI

a. Increased length of hospital stay

b. Increased cost; the non-inflation-adjusted attributable cost of CLABSIs has been found to vary from $3,700 to $29,000 per episode

Type
SHEA/IDSA Practice Recommendations
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Maki, DG, Kluger, DM, Crnich, CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin Proc 2006;81:11591171.Google Scholar
2.Esteve, F, Pujol, M, Limon, E, et al.Bloodstream infection related to catheter connections: a prospective trial of two connection systems. J Hosp Infect 2007;67:3034.Google Scholar
3.Climo, M, Diekema, D, Warren, DK, et al.Prevalence of the use of central venous access devices within and outside of the intensive care unit: results of a survey among hospitals in the prevention epicenter program of the Centers for Disease Control and Prevention. Infect Control Hosp Epidemiol 2003;24:942945.Google Scholar
4.Vonberg, RP, Behnke, M, Geffers, C, et al.Device-associated infection rates for non-intensive care unit patients. Infect Control Hosp Epidemiol 2006;27:357361.Google Scholar
5.Marschall, J, Leone, C, Jones, M, Nihill, D, Fraser, VJ, Warren, DK. Catheter-associated bloodstream infections in general medical patients outside the intensive care unit: a surveillance study. Infect Control Hosp Epidemiol 2007;28:905909.CrossRefGoogle ScholarPubMed
6.Pittet, D, Tarara, D, Wenzel, RP. Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA 1994;271:15981601.Google Scholar
7.DiGiovine, B, Chenoweth, C, Watts, C, Higgins, M. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am J Respir Crit Care Med 1999;160:976981.Google Scholar
8.Renaud, B, Brun-Buisson, C, ICU-Bacteremia Study Group. Outcomes of primary and catheter-related bacteremia: a cohort and case-control study in critically ill patients. Am J Respir Crit Care Med 2001;163:15841590.Google Scholar
9.Dimick, JB, Pelz, RK, Consunji, R, Swoboda, SM, Hendrix, CW, Lipsett, PA. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg 2001;136:229234.CrossRefGoogle ScholarPubMed
10.Warren, DK, Quadir, WW, Hollenbeak, CS, et al.Attributable cost of catheter-associated bloodstream infection among intensive care patients in a nonteaching hospital. Crit Care Med 2006;34:20842089.CrossRefGoogle Scholar
11.Mermel, LA. Prevention of intravascular catheter-related infections (published correction appears in Ann Intern Med 2000; 133:5). Ann Intern Med 2000;132:391402.CrossRefGoogle Scholar
12.Mermel, LA. Infections caused by intravascular devices. In: Pffeifer, JA, ed. APIC Text of Infection Control and Epidemiology. 2nd ed. St. Louis:Mosby; 2000:3038.Google Scholar
13.Almuneef, MA, Memish, ZA, Balkhy, HH, Hijazi, O, Cunningham, G, Francis, C. Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia. J Hosp Infect 2006;62:207213.CrossRefGoogle Scholar
14.Alonso-Echanove, J, Edwards, JR, Richards, MJ, et al.Effect of nurse staffing and antimicrobial-impregnated central venous catheters on the risk for bloodstream infections in intensive care units. Infect Control Hosp Epidemiol 2003;24:916925.CrossRefGoogle ScholarPubMed
15.Lorente, L, Henry, C, Martin, MM, Jimenez, A, Mora, ML. Central venous catheter-related infection in a prospective and observational study of 2,595 catheters. Crit Care 2005;9:R631R635.CrossRefGoogle Scholar
16. National Healthcare Safety Network, Centers for Disease Control and Prevention. The National Healthcare Safety Network (NHSN) manual: patient safety component protocol. January 2008. Available at: http://www.cdc.gov/ncidod/dhqp/pdf/nhsn/NHSN_Manual_PatientSafetyProtocol_CURRENT.pdf. Accessed July 30, 2008.Google Scholar
17.O'Grady, NP, Alexander, M, Dellinger, EP, et al.Guidelines for the prevention of intravascular catheter-related infections. MMWR Recomm Rep 2002;51(RR-10):129.Google ScholarPubMed
18. Institute for Healthcare Improvement. Available at: http://www.ihi.org/ihi. Accessed July 15, 2008.Google Scholar
19.Saint, S. Prevention of intravascular catheter-associated infections. In: Making Health Care Safer: A Critical Analysis of Patient Safety Practices. Evidence report/technology assessment, no. 43. AHRQ publication no. 01-E058. Rockville, MD: Agency for Healthcare Research and Quality;2001:163183. Available at: http://www.ahrq.gov/clinic/ptsafety/. Accessed July 16, 2008.Google Scholar
20.Sherertz, RJ, Ely, EW, Westbrook, DM, et al.Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med 2000;132:641648.Google Scholar
21.Canadian Task Force on the Periodic Health Examination. The periodic health examination. Can Med Assoc J 1979;121:11931254.Google Scholar
22.Pronovost, P, Needham, D, Berenholtz, S, et al.An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006;355:27252732.Google Scholar
23.Berenholtz, SM, Pronovost, PJ, Lipsett, PA, et al.Eliminating catheter-related bloodstream infections in the intensive care unit. Crit Care Med 2004;32:20142020.CrossRefGoogle ScholarPubMed
24.Muto, C, Herbert, C, Harrison, E, et al.Reduction in central line-associated bloodstream infections among patients in intensive care units—Pennsylvania, April 2001–March 2005. MMWR Morb Mortal Wkly Rep 2005;54:10131016.Google Scholar
25.Eggimann, P, Harbarth, S, Constantin, MN, Touveneau, S, Chevrolet, JC, Pittet, D. Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care. Lancet 2000;355:18641868.CrossRefGoogle ScholarPubMed
26.Coopersmith, CM, Rebmann, TL, Zack, JE, et al.Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit. Crit Care Med 2002;30:5964.Google Scholar
27.Warren, DK, Zack, JE, Cox, MJ, Cohen, MM, Fraser, VJ. An educational intervention to prevent catheter-associated bloodstream infections in a nonteaching, community medical center. Crit Care Med 2003;31:19591963.Google Scholar
28.Warren, DK, Zack, JE, Mayfield, JL, et al.The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. Chest 2004;126:16121618.Google Scholar
29.Tsuchida, T, Makimoto, K, Toki, M, Sakai, K, Onaka, E, Otani, Y. The effectiveness of a nurse-initiated intervention to reduce catheter-associated bloodstream infections in an urban acute hospital: an intervention study with before and after comparison. Int J Nurs Stud 2007;44:13241333.CrossRefGoogle Scholar
30. Occupational Health & Safety Administration, US Department of Labor. Available at: http://www.osha.gov/. Accessed July 15, 2008.Google Scholar
31.Yilmaz, G, Koksal, I, Aydin, K, Caylan, R, Sucu, N, Aksoy, F. Risk factors of catheter-related bloodstream infections in parenteral nutrition catheterization. JPEN J Parenter Enteral Nutr 2007;31:284287.CrossRefGoogle ScholarPubMed
32.Boyce, JM, Pittet, D. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. MMWR Recomm Rep 2002;51(RR-16):145.Google ScholarPubMed
33.Rosenthal, VD, Guzman, S, Safdar, N. Reduction in nosocomial infection with improved hand hygiene in intensive care units of a tertiary care hospital in Argentina. Am J Infect Control 2005;33:392397.CrossRefGoogle ScholarPubMed
34.Goetz, AM, Wagener, MM, Miller, JM, Muder, RR. Risk of infection due to central venous catheters: effect of site of placement and catheter type. Infect Control Hosp Epidemiol 1998;19:842845.Google Scholar
35.Merrer, J, De Jonghe, B, Golliot, F, et al.Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 2001;286:700707.CrossRefGoogle ScholarPubMed
36.Parienti, JJ, Thirion, M, Mégarbane, B, et al.Femoral versus jugular central catheterization in patients requiring renal replacement therapy: a randomized controlled study. JAMA 2008;299:24132422.Google Scholar
37.De Jonge, RCJ, Polderman, KH, Gemke, RJBJ. Central venous catheter use in the pediatric patient: mechanical and infectious complications. Pediatr Crit Care Med 2005;6:329339.CrossRefGoogle ScholarPubMed
38.Safdar, N, Maki, DG. Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. Chest 2005;128:489495.Google Scholar
39.Mermel, LA, McCormick, RD, Springman, SR, Maki, DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med 1991;91:197S205S.CrossRefGoogle ScholarPubMed
40.Raad, II, Hohn, DC, Gilbreath, BJ, et al.Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994;15:231238.CrossRefGoogle ScholarPubMed
41.Hu, KK, Lipsky, BA, Veenstra, DL, Saint, S. Using maximal sterile barriers to prevent central venous catheter-related infection: a systematic evidence-based review. Am J Infect Control 2004;32:142146.CrossRefGoogle ScholarPubMed
42.Young, EM, Commiskey, ML, Wilson, SJ. Translating evidence into practice to prevent central venous catheter-associated bloodstream infections: a systems-based intervention. Am J Infect Control 2006;34:503506.Google Scholar
43.Maki, DG, Ringer, M, Alvarado, CJ. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991;338:339343.CrossRefGoogle ScholarPubMed
44.Garland, JS, Buck, RK, Maloney, P, et al.Comparison of 10% povidone-iodine and 0.5% chlorhexidine gluconate for the prevention of peripheral intravenous catheter colonization in neonates: a prospective trial. Pediatr Infect Dis J 1995;14:510516.Google Scholar
45.Humar, A, Ostromecki, A, Direnfeld, J, et al.Prospective randomized trial of 10% povidone-iodine versus 0.5% tincture of chlorhexidine as cutaneous antisepsis for prevention of central venous catheter infection. Clin Infect Dis 2000;31:10011007.Google Scholar
46.Chaiyakunapruk, N, Veenstra, DL, Lipsky, BA, Saint, S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792801.Google Scholar
47.Salzman, MB, Isenberg, HD, Rubin, LG. Use of disinfectants to reduce microbial contamination of hubs of vascular catheters. J Clin Microbiol 1993;31:475479.CrossRefGoogle ScholarPubMed
48.Luebke, MA, Arduino, MJ, Duda, DL, et al.Comparison of the microbial barrier properties of a needleless and a conventional needle-based intravenous access system. Am J Infect Control 1998;26:437441.Google Scholar
49.Casey, AL, Worthington, T, Lambert, PA, Quinn, D, Faroqui, , Elliott, TS. A randomized, prospective clinical trial to assess the potential infection risk associated with the PosiFlow® needleless connector. J Hosp Infect 2003;54:288293.Google Scholar
50.Lederle, FA, Parenti, CM, Berskow, LC, Ellingson, KJ. The idle intravenous catheter. Ann Intern Med 1992;116:737738.Google Scholar
51.Parenti, CM, Lederle, FA, Impola, CL, Peterson, LR. Reduction of unnecessary intravenous catheter use: internal medicine house staff participate in a successful quality improvement project. Arch Intern Med 1994;154:18291832.CrossRefGoogle Scholar
52.Maki, DG, Stolz, SS, Wheeler, S, Mermel, LA. A prospective, randomized trial of gauze and two polyurethane dressings for site care of pulmonary artery catheters: implications for catheter management. Crit Care Med 1994;22:17291737.Google Scholar
53.Rasero, L, Degl'Innocenti, M, Mocali, M, et al.Comparison of two different time interval protocols for central venous catheter dressing in bone marrow transplant patients: results of a randomized, multicenter study. Haematologica 2000;85:275279.Google Scholar
54.Gillies, D, O'Riordan, L, Wallen, M, Morrison, A, Rankin, K, Nagy, S. Optimal timing for intravenous administration set replacement. Cochrane Database Syst Rev 2005;(4):142.Google Scholar
55.Gastmeier, P, Geffers, C, Brandt, C, et al.Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections. J Hosp Infect 2006;64:1622.CrossRefGoogle ScholarPubMed
56.National Healthcare Safety Network (NHSN), Department of Health and Human Services, Centers for Disease Control and Prevention. Available at: http://www.cdc.gov/ncidod/dhqp/nhsn.html. Accessed July 15, 2008.Google Scholar
57.Edwards, JR, Peterson, KD, Andrus, ML, et al.National Healthcare Safety Network (NHSN) report, data summary for 2006, issued June 2007. Am J Infect Control 2007;35:290301.Google Scholar
58.Levin, A, Mason, AJ, Jindal, KK, Fong, IW, Goldstein, MB. Prevention of hemodialysis subclavian vein catheter infections by topical povidone-iodine. Kidney Int 1991;40:934938.CrossRefGoogle ScholarPubMed
59.Zakrzewska-Bode, A, Muytjens, HL, Liem, KD, Hoogkamp-Korstanje, JA. Mupirocin resistance in coagulase-negative staphylococci, after topical prophylaxis for the reduction of colonization of central venous catheters. J Hosp Infect 1995;31:189193.Google Scholar
60.Riu, S, Ruiz, CG, Martinez-Vea, A, Peralta, C, Oliver, JA. Spontaneous rupture of polyurethane peritoneal catheter: a possible deleterious effect of mupirocin ointment. Nephrol Dial Transplant 1998;13:18701871.Google Scholar
61.Lok, CE, Stanley, KE, Hux, JE, Richardson, R, Tobe, SW, Conly, J. Hemodialysis infection prevention with polysporin ointment. J Am Soc Nephrol 2003;14:169179.Google Scholar
62.Fong, IW. Prevention of haemodialysis and peritoneal dialysis catheter related infection by topical povidone-iodine. Postgrad Med J 1993;69(Suppl 3):S15S17.Google Scholar
63.Bleasdale, SC, Trick, WE, Gonzales, IM, Lyles, RD, Hayden, MK, Weinstein, RA. Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients. Arch Intern Med 2007;167:20732079.Google Scholar
64.Maki, DG, Stolz, SM, Wheeler, S, Mermel, LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med 1997;127:257266.Google Scholar
65.Raad, I, Darouiche, R, Dupuis, J. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. The Texas Medical Center Catheter Study Group. Ann Intern Med 1997;127:267274.Google Scholar
66.Veenstra, DL, Saint, S, Saha, S, Lumley, T, Sullivan, SD. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infections: a meta-analysis. JAMA 1999;281:261267.CrossRefGoogle ScholarPubMed
67.Darouiche, RO, Raad, II, Heard, SO, et al.A comparison of two antimicrobial-impregnated central venous catheters: Catheter Study Group. N Engl J Med 1999;340:18.CrossRefGoogle ScholarPubMed
68.Hanna, HA, Raad, II, Hackett, B, et al., M.D. Anderson Catheter Study Group. Antibiotic-impregnated catheters associated with significant decrease in nosocomial and multidrug-resistant bacteremias in critically ill patients. Chest 2003;124:10301038.CrossRefGoogle Scholar
69.Hanna, H, Benjamin, R, Chatzinikolaou, I, et al.Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial. J Clin Oncol 2004;22:31633171.CrossRefGoogle ScholarPubMed
70.Rupp, ME, Lisco, SJ, Lipsett, PA, et al.Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trial. Ann Intern Med 2005;143:570580.Google Scholar
71.Chelliah, A, Heydon, KH, Zaoutis, TE, et al.Observational trial of antibiotic-coated central venous catheters in critically ill pediatric patients. Pediatr Infect Dis J 2007;26:816820.CrossRefGoogle ScholarPubMed
72.Bhutta, A, Gilliam, C, Honeycutt, M, et al.Reduction of bloodstream infections associated with catheters in paediatric intensive care unit: stepwise approach. BMJ 2007;334:362365.CrossRefGoogle ScholarPubMed
73.Garland, JS, Alex, CP, Mueller, CD, et al.A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. Pediatrics 2001;107:14311436.Google Scholar
74.Levy, I, Katz, J, Solter, E, et al.Chlorhexidine-impregnated dressing for prevention of colonization of central venous catheters in infants and children: a randomized controlled study. Pediatr Infect Dis J 2005;24:676679.Google Scholar
75.Ho, KM, Litton, E. Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis. J Antimicrob Chemother 2006;58:281287.CrossRefGoogle ScholarPubMed
76.Carratala, J, Niubo, J, Fernandez-Sevilla, A, et al.Randomized, double-blind trial of an antibiotic-lock technique for prevention of gram-positive central venous catheter-related infection in neutropenic patients with cancer. Antimicrob Agents Chemother 1999;43:22002204.CrossRefGoogle ScholarPubMed
77.Henrickson, KJ, Axtell, RA, Hoover, SM, et al.Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: a randomized, multicenter, double-blind trial. J Clin Oncol 2000;18:12691278.CrossRefGoogle ScholarPubMed
78.Safdar, N, Maki, DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective, randomized trials. Clin Infect Dis 2006;43:474484.CrossRefGoogle ScholarPubMed
79.Labriola, L, Crott, R, Jadoul, M. Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: a meta-analysis of prospective randomized trials. Nephrol Dial Transplant 2008;23:16661672.CrossRefGoogle ScholarPubMed
80.Saxena, AK, Panhotra, BR, Naguib, M. Sudden irreversible sensory-neural hearing loss in a patient with diabetes receiving amikacin as an antibiotic heparin lock. Pharmacotherapy 2002;22:105–8.Google Scholar
81.McKee, R, Dunsmuir, R, Whitby, M, Garden, OJ. Does antibiotic prophylaxis at the time of catheter insertion reduce the incidence of catheter-related sepsis in intravenous nutrition? J Hosp Infect 1985;6:419425.Google Scholar
82.Ranson, MR, Oppenheim, BA, Jackson, A, Kamthan, AG, Scarffe, JH. Double-blind placebo controlled study of vancomycin prophylaxis for central venous catheter insertion in cancer patients. J Hosp Infect 1990;15:95102.CrossRefGoogle ScholarPubMed
83.Sandoe, JA, Kumar, B, Stoddart, B, et al.Effect of extended perioperative antibiotic prophylaxis on intravascular catheter colonization and infection in cardiothoracic surgery patients. J Antimicrob Chemother 2003;52:877879.Google Scholar
84.Van de Wetering, MD, van Woensel, JBM, Kremer, LCM, Caron, HN. Prophylactic antibiotics for preventing early Gram-positive central venous catheter infections in oncology patients, a Cochrane systematic review. Cancer Treat Rev 2005;31:186196.Google Scholar
85.Eyer, S, Brummitt, C, Crossley, K, Siegel, R, Cerra, F. Catheter-related sepsis: prospective, randomized study of three methods of long-term catheter maintenance. Crit Care Med 1990;18:10731079.CrossRefGoogle ScholarPubMed
86.Cobb, DK, High, KP, Sawyer, RG, et al.A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med 1992;327:10621068.Google Scholar
87.Cook, D, Randolph, A, Kernerman, P, et al.Central venous catheter replacement strategies: a systematic review of the literature. Crit Care Med 1997;25:14171424.Google Scholar
88.Maragakis, LL, Bradley, KL, Song, X, et al.Increased catheter-related bloodstream infection rates after the introduction of a new mechanical valve intravenous access port. Infect Control Hosp Epidemiol 2006;27:6770.Google Scholar
89.Field, K, McFarlane, C, Cheng, AC, et al.Incidence of catheter-related bloodstream infection among patients with a needleless, mechanical valve–based intravenous connector in an Australian hematology-oncology unit. Infect Control Hosp Epidemiol 2007;28:610613.CrossRefGoogle Scholar
90.Salgado, CD, Chinnes, L, Paczesny, TH, Cantey, JR. Increased rate of catheter-related bloodstream infection associated with use of a needleless mechanical valve device at a long-term acute care hospital. Infect Control Hosp Epidemiol 2007;28:684688.Google Scholar
91.Rupp, ME, Sholtz, LA, Jourdan, DR, et al.Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve. Clin Infect Dis 2007;44:14081414.CrossRefGoogle ScholarPubMed
92.Fridkin, SK, Pear, SM, Williamson, TH, Galgiani, JN, Jarvis, WR. The role of understaffing in central venous catheter-associated bloodstream infections. Infect Control Hosp Epidemiol 1996;17:150158.Google Scholar
93.Robert, J, Fridkin, SK, Blumberg, HM, et al.The influence of the composition of the nursing staff on primary bloodstream infection rates in a surgical intensive care unit. Infect Control Hosp Epidemiol 2000;21:1217.Google Scholar
94.Stone, PW, Mooney-Kane, C, Larson, EL, et al.Nurse working conditions and patient safety outcomes. Med Care 2007;45:571578.CrossRefGoogle ScholarPubMed
95.Miller, JM, Goetz, AM, Squier, C, Muder, RR. Reduction in nosocomial intravenous device-related bacteremias after institution of an intravenous therapy team. J Intraven Nurs 1996;19:103106.Google Scholar
96.Soifer, NE, Borzak, S, Edlin, BR, Weinstein, RA. Prevention of peripheral venous catheter complications with an intravenous therapy team: a randomized controlled trial. Arch Intern Med 1998;158:473477.Google Scholar
97.Tokars, JI, Klevens, RM, Edwards, JR, Horan, TC. Measurement of the impact of risk adjustment for central line–days on interpretation of central line–associated bloodstream infection rates. Infect Control Hosp Epidemiol 2007;28:10251029.Google Scholar
98.Klevens, RM, Tokars, JI, Edwards, J, et al.Sampling for collection of central line–day denominators in surveillance of healthcare-associated bloodstream infections. Infect Control Hosp Epidemiol 2006;27:338342.Google Scholar
99. Institute for Healthcare Improvement. Central line insertion checklist. Available at: http://www.ihi.org/IHI/Topics/CriticalCare/IntensiveCare/Tools/CentralLineInsertionChecklist.htm. Accessed July 30, 2008.Google Scholar
100.Widmer, AF, Nettleman, M, Flint, K, Wenzel, RP. The clinical impact of culturing central venous catheters: a prospective study. Arch Intern Med 1992;152:12991302.Google Scholar
101.Raad, II, Baba, M, Bodey, GP. Diagnosis of catheter-related infections: the role of surveillance and targeted quantitative skin cultures. Clin Infect Dis 1995;20:593597.CrossRefGoogle ScholarPubMed
102.Pittet, D, Wenzel, RP. Nosocomial bloodstream infections: secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med 1995;155:11771184.CrossRefGoogle ScholarPubMed
103.Wong, ES, Rupp, ME, Mermel, L, et al.Public disclosure of healthcare-associated infections: the role of the Society for Healthcare Epidemiology of America. Infect Control Hosp Epidemiol 2005;26:210212.CrossRefGoogle ScholarPubMed
104.McKibben, L, Horan, TC, Tokars, JI, et al.Guidance on public reporting of healthcare-associated infections: recommendations of the Healthcare Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 2005;26:580587.Google Scholar
105. Healthcare-Associated Infection Working Group of the Joint Public Policy Committee. Essentials of public reporting of healthcare-associated infections: a tool kit. January 2007. Available at: http://www.cdc.gov/ncidod/dhqp/pdf/ar/06_107498_Essentials_Tool_Kit.pdf. Accessed July 15, 2008.Google Scholar
106.The National Quality Forum. National voluntary consensus standards for the reporting of healthcare-associated infection data: a consensus report. Available at: http://www.qualityforum.org/pdf/reports/HAI%20Report.pdf. Accessed August 25, 2008.Google Scholar