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Seroprevalence Survey of Varicella, Measles, Rubella, and Hepatitis A and B Viruses in a Multinational Healthcare Workforce in Saudi Arabia

Published online by Cambridge University Press:  21 June 2016

M. A. Almuneef ,
Z. A. Memish ,
H. H. Balkhy ,
B. Otaibi  and
M. Helmi
M. A. Almuneef
Affiliation:
Departments of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia Pediatrics, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia
Z. A. Memish*
Affiliation:
Departments of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia Internal Medicine, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia
H. H. Balkhy
Affiliation:
Departments of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia Pediatrics, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia
B. Otaibi
Affiliation:
Departments of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia
M. Helmi
Affiliation:
Departments of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, Riyadh, Saudi Arabia
*
Adult Infectious Diseases Division, Department of Medicine, Infection Prevention and Control National Guard Health Affairs, King Abdulaziz Medical City-King Fahad National Guard Hospital, P.O. Box 22490, Riyadh 11426, Kingdom of Saudi Arabia ([email protected])
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Abstract

Objective.

To determine the prevalence of the vaccine-preventable diseases caused by varicella, measles, rubella, and hepatitis A and B viruses in a multinational healthcare workforce.

Design.

Prospective cohort study.

Setting.

A 750-bed tertiary care center located in Riyadh, Saudi Arabia.

Methods.

In compliance with hospital policy, newly recruited healthcare workers (HCWs) were enrolled in the study from September 2001 to March 2005. Serum samples were collected from all HCWs during the initial hiring process and tested for IgG antibodies against each of the 5 viral agents. Nonimmune HCWs were subsequently vaccinated at the earliest opportunity.

Results.

A total of 4,006 newly hired (international and local) employees were included in the study. All underwent serologic testing for IgG antibodies against varicella, measles, rubella, hepatitis A, and hepatitis B viruses. Of the total, 63% were female and 37% were male. Middle Eastern employees comprised 47% of the total, followed by employees from the Far East (35%), the West (10%), and Africa (8%). Forty-two percent were nurses, 27% were in administration, 18% were medical technicians, and 13% were physicians. Among the 4,006 newly hired HCWs, 14% had negative IgG antibody test results for varicella virus, 13% for measles virus, 10% for rubella virus, 33% for hepatitis A virus, and 43% for hepatitis B virus. More women than men were susceptible to hepatitis A (40% vs. 24%; P< .001), whereas more men were susceptible to hepatitis B (55% vs. 35%; P< .001). Varicella susceptibility was more common among HCWs from the Far East (19%), whereas susceptibility to measles, rubella, hepatitis A, and hepatitis B was highest among HCWs from the Middle East. Both relative youth and male sex were associated with lack of antibodies against hepatitis B virus and rubella virus. In contrast, female sex and younger age were associated with lack of antibodies against hepatitis A virus (P< .001).

Conclusion.

Seroprevalence surveys of vaccine-preventable diseases among HCWs, although labor intensive, are invaluable in caring for a multinational workforce.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 11 , November 2006 , pp. 1179 - 1183
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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References

1. Centers for Disease Control and Prevention. Immunization of healthcare workers: recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Morb Mortal Wkly Rep 1997;46(RR-18):1–42.Google Scholar
2. Centers for Disease Control and Prevention. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through childhood immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1991; 40(RR-13):1–25.Google Scholar
3. Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1996; 45(RR-15):1–30.Google Scholar
4. Centers for Disease Control and Prevention. Measles prevention: recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Morb Mortal Wkly Rep 1989; 38(S-9):1–18.Google Scholar
5. Centers for Disease Control and Prevention. Rubella prevention: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1990; 39(RR-15):1–13.Google Scholar
6. Centers for Disease Control and Prevention. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1999; 48(RR-6):1–5.Google Scholar
7. Centers for Disease Control and Prevention. Guidelines for infection control in healthcare personnel: recommendations of the Hospital Infection Control Practices Advisory Committee. Am J Infect Control 1998; 19:407–463.Google Scholar
8. Struewing, JP, Hyams, KC, Tueller, JE, Gray, GC. The risk of measles, mumps, and varicella among young adults: a serology of US Navy and Marine Corps recruits. Am J Public Health 1993; 83:1717–1720.Google Scholar
9. Tennenberg, AM, Brassard, JE, Van Lieu, J, Drusin, LM. Varicella vaccination for healthcare workers at a university hospital: an analysis of costs and benefits. Infect Control Hosp Epidemiol 1997; 18:405–411.Google Scholar
10. Agut, H. Prevention and control of viral hospital infections. Am J Infect Control 2001; 29:244–246.CrossRefGoogle ScholarPubMed
11. Measles, mumps, and rubella: vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1998; 47(RR-8):1–57.Google Scholar
12. Almuneef, M, Dillon, J, Abbas, MF, Memish, ZA. Varicella zoster virus immunity in multinational healthcare workers of a Saudi Arabian hospital. Am J Infect Control 2003; 31:375–381.Google Scholar
13. Almuneef, M, Memish, ZA, Abbas, MF, Balkhy, HH. Screening healthcare workers for varicella-zoster virus: can we trust the history? Infect Control Hosp Epidemiol 2004; 25:595–598.Google Scholar
14. Memish, ZA, Almuneef, M, Dillon, J. Epidemiology of needlestick and sharps injuries in a tertiary care center in Saudi Arabia. Am J Infect Control 2002; 30:234–241.Google Scholar
15. Brunell, PA, Wood, D. Varicella serological status of healthcare workers as a guide to whom to test or immunize. Infect Control Hosp Epidemiol 1999; 20:355–357.Google Scholar
16. Quereshi, M, Gordon, SM, Yen-Lieberman, B, Litaker, DG. Controlling varicella in the healthcare setting: barriers to varicella vaccination among healthcare workers. Infect Control Hosp Epidemiol 1999; 20:516–518.Google Scholar
17. Gallagher, J, Quaid, B, Cryan, B. Susceptibility to varicella-zoster virus infection in healthcare workers. Occup Med (London) 1996; 46:289–292.CrossRefGoogle Scholar
18. Vandermissen, G, Mosens, G, Vranckx, R, deSchryver, A, Jacques, P. Occupational risk of infection by varicella-zoster virus in Belgian healthcare workers: a seroprevalence study. Occup Environ Med 2000; 57:621–626.Google Scholar
19. Lolekha, S, Tanthiphabha, W, Sornchai, P, et al. Effect of climatic factors and population density on varicella-zoster virus epidemiology within a tropical country. Am J Trop Med Hyg 2001; 64:131–136.CrossRefGoogle ScholarPubMed
20. Richard, VS, John, TJ, Kenneth, J, Ramaprabha, P, Kyruvilla, PG, Chardy, GM. Should healthcare workers in the tropics be immunized against varicella. J Hosp Infect 2001; 47:243–245.CrossRefGoogle ScholarPubMed
21. Arvin, AM. Varicella-zoster virus. Clin Microbiol Rev 1996; 9:361–381.Google Scholar
22. Memish, ZA, Oni, GA, Banetyne, RM, Qassem, L. The cost saving potential of prevaccination antibody tests when implementing a mass immunization program. Mil Med 2001; 166:11–13.Google Scholar
23. Atkinson, WL. Measles and healthcare workers. Infect Control Hosp Epidemiol 1994; 15:5–7.Google Scholar
24. Atkinson, WL, Hadler, SC, Redd, SB, Orenstein, WA. Measles surveillance United States, 1991. MMWR CDC Surveill Summ 1992; 41(6):1–12.Google ScholarPubMed
25. Gdalevich, M, Robin, G, Mimouni, D, Grotto, I, Shpilberg, O, Ashkenazi, I. Measles antibody prevalence rates among young adults in Israel. Am J Infect Control 2002; 30:165–169.Google Scholar
26. Asari, S, Deguchi, M, Tahara, K, et al. Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in healthcare workers and evaluation of a vaccination program in a tertiary care hospital in Japan. Am J Infect Control 2003; 31:157–162.CrossRefGoogle Scholar
27. Al-Mazrou, YY, Khalil, MK, Tumsah, S, et al. Sero-response to measles-mumps-rubella vaccine campaign in Saudi Arabia. Saudi Med J 2002; 23:680–683.Google ScholarPubMed
28. Al-Shehri, SN, Al-Shammari, SA. Immunization coverage survey in eight regions of Saudi Arabia. Ann Trop Paediatr 1991; 11:181–187.Google Scholar
29. Al-Mazrou, YY, Al-Jeffri, M, Ahmed, OM, Aziz, KM, Mishkas, AH. Measles immunization: early two-doses policy experience. J Trop Pediatr 1999; 45:98–104.Google Scholar
30. Farag, MK, Al-Mazrou, YY, Al-Jeffry, M, Al-Shehri, SN, Baldo, MH, Farghali, M. National immunization coverage survey Saudi Arabia, 1991. J Trop Pediatr 1995; 41:59–67.Google Scholar
31. Memish, ZA, Qassem, L, Abed, E, et al. Pattern of viral hepatitis infection in a selected population from Saudi Arabia. Mil Med 2003; 168:565–568.Google Scholar
32. Memish, ZA, Sobayo, EI. Personalized education improves hepatitis B vaccination rate among physicians in Saudi Arabia. Infect Control Hosp Epidemiol 1998; 19:887–888.CrossRefGoogle ScholarPubMed
33. Faleh Zaid Al-Faleh, F. Changing pattern of Hepatitis viral infection in Saudi Arabia in the last two decades. Ann Saudi Med 2003; 23:367–371.Google Scholar