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Seasonal and Ascending Trends in the Incidence of Carriage of Extended-Spectrum β-Lactamase–Producing Escherichia coli and Klebsiella Species in 2 German Hospitals

Published online by Cambridge University Press:  02 January 2015

Klaus Kaier Dipl-Vw ,
Uwe Frank ,
Andreas Conrad  and
Elisabeth Meyer
Klaus Kaier Dipl-Vw*
Affiliation:
Department of Environmental Health Sciences, University Medical Center Freiburg, Berlin, Germany Research Center for Generational Contracts, Freiburg University, Freiburg, Germany
Uwe Frank
Affiliation:
Department of Environmental Health Sciences, University Medical Center Freiburg, Berlin, Germany
Andreas Conrad
Affiliation:
Department of Environmental Health Sciences, University Medical Center Freiburg, Berlin, Germany
Elisabeth Meyer
Affiliation:
Institute of Hygiene and Environmental Medicine, Charité University Medicine, Berlin, Germany
*
Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Straße ] 15b, D-79106 Freiburg, Germany, ([email protected])
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Extract

Background.

Extended-spectrum β-lactamase (ESBL)–producing strains of bacteria have become a major public health concern. In the present study, the incidence of carriage of ESBL-producing strains was analyzed for general trends and seasonality.

Methods.

Monthly data on ESBL-producing strains were collected retrospectively at 2 large university hospitals in Germany. The mean monthly temperatures for the 2 settings were collected from Germany's national meteorological service. Multivariable time series analyses were performed to explain variations in the monthly incidence densities of carriage of ESBL-producing bacteria (number of cases involving ESBL-producing Escherichia coli and/or Klebsiella species per 1,000 patient days). For the final models, we incorporated variables for the ascending linear trends and other variables representing the mean monthly temperature.

Results.

Our models demonstrated that there was an increasing trend in the incidences of carriage of ESBL-producing bacteria. In addition, the incidences of carriage of all ESBL-producing bacteria responded positively to the mean temperature, meaning that during the summer, more cases involving ESBL-producing bacteria were detected than during the winter. The same methodology was also applied to the incidence of methicillin-resistant Staphylococcus aureus carriage, but no association was found with the mean temperature.

Conclusions.

In the present study, we demonstrated that the monthly incidence of carriage of ESBL-producing bacteria was highly correlated with the mean monthly temperature, a fact that should be considered in experimental studies as an additional parameter influencing the incidence of ESBL-producing bacteria.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 31 , Issue 11 , November 2010 , pp. 1154 - 1159
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2010

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