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Risk Factors for Nosocomial Infective Endocarditis in Patients with Methicillin-Resistant Staphylococcus Aureus Bacteremia

Published online by Cambridge University Press:  21 June 2016

Ron-Bin Hsu
Ron-Bin Hsu*
Affiliation:
Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
*
National Taiwan University Hospital, No. 7, Chung-Shan S. Rd., Taipei, Taiwan 100, Republic of China.[email protected]
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Abstract

Background and Objective:

Nosocomial infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are increasing. Only a few studies of MRSA infective endocarditis have been conducted, and none have reported its risk factors. We sought to determine the host-related risk factors for infective endocarditis in patients with nosocomial MRSA bacteremia.

Setting:

A 2,000-bed, university-affiliated, tertiary-care hospital.

Patients:

Thirty-one patients with nosocomial MRSA infective endocarditis between October 1996 and May 2003.

Design:

A retrospective chart review was conducted. Data were compared with those from a control group of patients with nosocomial MRSA bacteremia. Logistic regression was used to identify independent risk factors for nosocomial infective endocarditis.

Results:

Compared with patients who had nosocomial MRSA bacteremia and no infective endocarditis, patients who had infective endocarditis had a higher incidence of chronic liver disease and a lower incidence of immunodeficiency. The risk of developing infective endocarditis was approximately 10% for patients with nosocomial MRSA bacteremia.

Conclusion:

Patients with MRSA bacteremia and underlying chronic liver disease were prone to infective endocarditis. (Infect Control Hosp Epidemiol 2005;26:654-657)

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 26 , Issue 7 , July 2005 , pp. 654 - 657
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2005

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References

1.Netzer, RO, Altwegg, SC, Zollinger, E, et al.Infective endocarditis: determinants of long term outcome. Heart 2002:88:61–66.Google Scholar
2.Bouza, E, Menasalvas, A, Munoz, P, et al. Infective endocarditis: a prospective study at the end of the twentieth century. New predisposing conditions, new etiologic agents, and still a high mortality. Medicine 2001;80:298–307.Google Scholar
3.Hoen, B, Alla, F, Selton-Suty, C, et al.Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA 2002;288:75–81.Google Scholar
4.Espersen, F, Frimodt-Moller, N. Staphylococcus aureus endocarditis. Arch Intern Med 1986;146:1118–1121.Google Scholar
5.Cabell, CH, Jollis, JG, Peterson, GE, et al.Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med 2002;162:90–94.Google Scholar
6.Roder, BL, Wandall, DA, Frimodt-Moller, N, et al.Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. Arch Intern Med 1999;159:462–469.CrossRefGoogle ScholarPubMed
7.Sanabria, TJ, Alpert, JS, Goldberg, R, Pape, LA, Cheeseman, SH. Increasing frequency of staphylococcal infective endocarditis. Arch Intern Med 1990;150:1305–1309.Google Scholar
8.Fowler, VG Jr, Sanders, LL, Kong, LK, et al.Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis 1999;28:106–114.Google Scholar
9.Salmenlinna, S, Lyytikainen, O, Vuopio-Varkila, J. Community-acquired methicillin-resistant Staphylococcus aureus, Finland. Emerg Infect Dis 2002;8:602–607.CrossRefGoogle ScholarPubMed
10.Gentry, CA, Rodvold, KA, Novak, RM, Hershow, RC, Naderer, OJ. Retrospective evaluation of therapies for Staphylococcus aureus endocarditis. Pharmacotherapy 1997;17:990–997.Google Scholar
11.Levine, DP, Fromm, BS, Reddy, BR. Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis. Ann Intern Med 1991;115:674–680.CrossRefGoogle ScholarPubMed
12.Strom, BL, Abrutyn, E, Berlin, JA, et al.Risk factors for infective endocarditis: oral hygiene and nondental exposures. Circulation 2000; 102:2842–2848.CrossRefGoogle ScholarPubMed
13.Strom, BL, Abrutyn, E, Berlin, JA, et al.Dental and cardiac risk factors for infective endocarditis: a population-based, case-control study. Ann Intern Med 1998;129:761–769.Google Scholar
14.Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128–140.CrossRefGoogle ScholarPubMed
15.Li, JS, Sexton, DJ, Mick, N, et al.Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000;30:633–638.Google Scholar
16.Wang, JT, Chang, SC, Ko, WJ, et al.A hospital-acquired outbreak of methicillin-resistant Staphylococcus aureus infection initiated by a surgeon carrier. J Hosp Infect 2001;47:104–109.CrossRefGoogle ScholarPubMed
17.Giamarellou, H. Nosocomial cardiac infections. J Hosp Infect 2002;50: 91–105.CrossRefGoogle ScholarPubMed
18.McGowan, JE Jr, Tenover, FC. Control of antimicrobial resistance in the health care system. Infect Dis Clin North Am 1997;11:297–311.CrossRefGoogle ScholarPubMed
19.Hsueh, PR, Chen, ML, Sun, CC, et al.Antimicrobial drug resistance in pathogens causing nosocomial infections at a university hospital in Taiwan, 1981-1999. Emerg Infect Dis 2002;8:63–68.CrossRefGoogle Scholar
20.Wang, JT, Chen, YC, Yang, TL, Chang, SC. Molecular epidemiology and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus in Taiwan. Diagn Microbiol Infect Dis 2002;42:199–203.CrossRefGoogle ScholarPubMed
21.Cosgrove, SE, Sakoulas, G, Perencevich, EN, Schwaber, MJ, Karchmer, AW, Carmeli, Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003;36:53–59.Google Scholar
22.Roghmann, MC. Predicting methicillin resistance and the effect of inadequate empiric therapy on survival in patients with Staphylococcus aureus bacteremia. Arch Intern Med 2000;160:1001–1004.CrossRefGoogle Scholar
23.Talon, D, Woronoff-Lemsi, MC, Limat, S, et al.The impact of resistance to methicillin in Staphylococcus aureus bacteremia on mortality. Eur J Intern Med 2002;13:31–36.CrossRefGoogle ScholarPubMed
24.Soriano, A, Martinez, JA, Mensa, J, et al.Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis 2000;30:368–673.Google Scholar
25.Harbarth, S, Rutschmann, O, Sudre, P, Pittet, D. Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus. Arch Intern Med 1998;158:182–189.Google Scholar
26.Romero-Vivas, J, Rubio, M, Fernandez, C, Picazo, JJ. Mortality associated with nosocomial bacteremia due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1995;21:1417–1423.Google Scholar
27.Lewis, E, Saravolatz, LD. Comparison of methicillin-resistant and methicillin-sensitive Staphylococcus aureus bacteremia. Am J Infect Control 1985;13:109–114.Google Scholar
28.Johnson, DH, Cunha, BA. Infections in cirrhosis. Infect Dis Clin North Am 2001;15:363–371.Google Scholar
29.McCashland, TM, Sorrell, MF, Zetterman, RK. Bacterial endocarditis in patients with chronic liver disease. Am J Gastroenterol 1994;89:924–927.Google ScholarPubMed
30.Denton, JH, Rubio, C, Velazquez, J, de Arellano, GR. Bacterial endocarditis in cirrhosis. Dig Dis Sci 1981;26:935–937.CrossRefGoogle ScholarPubMed
31.Hsu, RB, Tsay, YG, Chen, RJ, Chu, SH. Risk factors for primary bacteremia and endovascular infection in patients without acquired immunodeficiency syndrome who have nontyphoid salmonellosis. Clin Infect Dis 2003;36:829–834.CrossRefGoogle ScholarPubMed