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Risk Factors for Clostridium difficile Infection in a Hepatology Ward

Published online by Cambridge University Press:  02 January 2015

Dominique Vanjak ,
Guillaume Girault ,
Catherine Branger ,
Pierre Rufat ,
Dominique-Charles Valla  and
Bruno Fantin
Dominique Vanjak*
Affiliation:
Unité d'hygiène et de lutte contre les infections nosocomiales, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
Guillaume Girault
Affiliation:
Laboratoire de Microbiologie, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
Catherine Branger
Affiliation:
Laboratoire de Microbiologie, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
Pierre Rufat
Affiliation:
Unité d'information médicale, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
Dominique-Charles Valla
Affiliation:
Service d'Hépatologie, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
Bruno Fantin
Affiliation:
Service de Médecine interne, Hôpital Beaujon, AP-HP, Université Paris 7, Clichy, France
*
Hôpital Beaujon, AP-HP, Unité d'hygiène et de lutte contre les infections nosocomiales, 100 avenue du général Leclerc, 92118 Clichy cedex, France ([email protected])
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Abstract

During 2001, Clostridium difficile infection was observed in 23 patients hospitalized in a hepatology ward (attack rate, 0.9%). Since strain typing ruled out a clonal dissemination, we performed a case-control study. In addition to antibiotic use as a risk factor, the C. difficile infection rate was higher among patients with autoimmune hepatitis (P < .01).

Type
Concise Communication
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 2 , February 2007 , pp. 202 - 204
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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References

1.McFarland, LV, Mulligan, ME, Kwok, RYY, Stamm, WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989;320:204–210.Google Scholar
2.Blot, E, Escande, MC, Besson, D, et al. Outbreak of Clostridium difficile-related diarrhoea in an adult oncology unit: risk factors and microbiological characteristics. J Hosp Infect 2003;53:187–192.Google Scholar
3.Kyne, L, Sougioultzis, S, McFarland, LV, et al. Underlying disease severity as a major risk factor for nosocomial Clostridium difficile diarrhea. Infect Control Hosp Epidemiol 2002;23:653–664.Google Scholar
4.Barbut, F, Mario, M, Meyohas, MC, et al. Investigation of a nosocomial outbreak of Clostridium difficile-associated diarrhoea among AIDS patients by random amplified polymorphic DNA (RAPD) assay. J Hosp Infect 1994;26:181–189.Google Scholar
5.Johnson, S, Gerding, DN. Clostridium difficile-associated diarrhea. Clin Infect Dis 1998;26:1027–1034.Google Scholar
6.Clabots, CR, Johnson, S, Peterson, LR, Mulligan, ME, Silva, J. Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J Infect Dis 1992;166:561–567.Google Scholar
7.McFarland, LV, Surawicz, CM, Stamm, WE. Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. J Infect Dis 1990;162:678–684.Google Scholar
8.Brown, E, Talbot, GH, Axelrod, P, et al. Risk factors for Clostridium difficile toxin-associated diarrhea. Infect Control Hosp Epidemiol 1990;11:283–290.Google Scholar
9.Lai, KK, Melvin, ZS, Menard, MJ, Kotilainen, HR, Baker, S. Clostridium difficile-associzted diarrhea: epidemiology, risk factors, and infection control. Infect Control Hosp Epidemiol 1997;18:628–632.Google Scholar
10.Kato, N, Ou, CY, Kato, H, et al. Identification of toxigenic Clostridium difficile by the polymerase chain reaction. J Clin Microbiol 1991;29:33–37.Google Scholar
11.Lemann, F, Chambon, C, Barbut, F, et al. Arbitrary primed PCR rules out Clostridium difficile cross-infection among patients in a haematology unit. J Hosp Infect 1997;35:107–115.Google Scholar
12.Hutin, Y, Molina, JM, Casin, I, et al. Risk factors for Clostridium difficile-associated diarrhoea in HIV-infected patients. AIDS 1993;7:1441–1447.Google Scholar
13.Gorschlüter, M, Glasmacher, A, Hahn, C, et al. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2001;33:786–791.Google Scholar
14.Kyne, L, Warny, M, Qamar, A, et al. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000;342:390–397.Google Scholar
15.Alvarez, F, Berg, PA, Bianchi, L, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929–938.Google Scholar