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Resistance to Antibiotics in Clinical Isolates of Klebsiella pneumoniae

Published online by Cambridge University Press:  02 January 2015

Thomas F. O'Brien ,
Kenneth H. Mayer ,
John D. Hopkins ,
John J. Farrell ,
Lee Chao  and
Ralph L. Kent
Thomas F. O'Brien*
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
Kenneth H. Mayer
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
John D. Hopkins
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
John J. Farrell
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
Lee Chao
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
Ralph L. Kent
Affiliation:
Department of Medicine of the Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts
*
Microbiology Laboratory, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
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Abstract

The antibiotic resistance of Klebsiella pneumoniae isolates from 12 medical centers worldwide, over a 1- to 6-year period, were tested. Clinical isolates of K. pneumoniae were resistant to ampicillin and carbenicillin. Resistance to other antibiotics was less frequent with isolates of K. pneumoniae from 5 of 6 US centers than with those from 6 centers outside the US. In nearly all of the centers, resistance to sulfamethoxazole-trimethoprim, gentamicin, tobramycin, or chloramphenicol was more frequent in isolates of K. pneumoniae than in those of Escherichia coli, while the reverse was true for resistance to tetracycline. Resistance to multiple antibiotics declined gradually in isolates of K. pneumoniae at one center, but rose abruptly again with dissemination of a new plasmid.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 6 , Issue 2 , February 1985 , pp. 64 - 67
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1985

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References

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