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Recurrent colonization with methicillin-susceptible Staphylococcus aureus after successful decolonization in a neonatal intensive care unit

Published online by Cambridge University Press:  16 October 2024

Archana Balamohan*
Affiliation:
Cohen Children’s Medical Center of New York, New York, NY, USA
Medini K. Annavajhala
Affiliation:
Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA
Vitaliya Boyar
Affiliation:
Cohen Children’s Medical Center of New York, New York, NY, USA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA
Alexander Chong
Affiliation:
Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA
Anne-Catrin Uhlemann
Affiliation:
Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Medicine, the New York Presbyterian Hospital, New York, NY, USA
Lorry G. Rubin
Affiliation:
Cohen Children’s Medical Center of New York, New York, NY, USA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA
*
Corresponding author: Archana Balamohan; Email: [email protected]

Abstract

Recurrent methicillin-susceptible Staphylococcus aureus colonization following successful decolonization in a neonatal intensive care unit (NICU) has been observed. Of 17 recolonization events, 53% were due to concordant strains; 19 different spa types were identified. Results of this study support sources of re-acquisition both intrinsic and extrinsic to the NICU.

Type
Concise Communication
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Ericson, JE, Popoola, VO, Smith, PB, Benjamin, DK, Fowler, VG, Benjamin, DK Jr, et al. Burden of invasive Staphylococcus aureus infections in hospitalized infants. JAMA Pediatr 2015;169:11051111.CrossRefGoogle ScholarPubMed
Akinboyo, IC, Zangwill, KM, Berg, WM, Cantey, JB, Huizinga, B, Milstone, AM. SHEA neonatal intensive care unit (NICU) white paper series: practical approaches to Staphylococcus aureus disease prevention. Infect Control Hosp Epidemiol 2020;41:12511257. https://doi.org/10.1017/ice.2020.51 CrossRefGoogle ScholarPubMed
Wisgrill, L, Zizka, J, Unterasinger, L, Rittenschober-Böhm, J, Waldhör, T, Makristathis, A, Berger, A. Active surveillance cultures and targeted decolonization are associated with reduced methicillin-susceptible Staphylococcus aureus infections in VLBW infants. Neonatology. 2017;112:267273. doi: 10.1159/000477295.CrossRefGoogle ScholarPubMed
Voskertchian, A, Akinboyo, IC, Colantuoni, E, Johnson, J, Milstone, AM. Association of an active surveillance and decolonization program on incidence of clinical cultures growing Staphylococcus aureus in the neonatal intensive care unit. Infect Control Hosp Epidemiol 2018;39:882884. doi: 10.1017/ice.2018.81.CrossRefGoogle ScholarPubMed
Balamohan, A, Beachy, J, Kohn, N, Rubin, LG. The effect of routine surveillance and decolonization on the rate of Staphylococcus aureus infections in a level IV neonatal intensive care unit. J Perinatol 2020;40:16441651. doi: 10.1038/s41372-020-0755-5.CrossRefGoogle Scholar
Nelson, MU, Shaw, J, Gross, SJ. Randomized placebo-controlled trial of topical mupirocin to reduce Staphylococcus aureus colonization in infants in the neonatal intensive care unit. J Pediatr 2021;236:7077. doi: 10.1016/j.jpeds.2021.05.042.CrossRefGoogle ScholarPubMed
Kotloff, KL, Shirley, DT, Creech, CB, Frey, SE, Harrison, CJ, Staat, M, Anderson, EJ, Dulkerian, S, Thomsen, IP, Al-Hosni, M, Pahud, BA, Bernstein, DI, Yi, J, Petrikin, JE, Haberman, B, Stephens, K, Stephens, I, Oler, RE Jr, Conrad, TM. Mupirocin for Staphylococcus aureus decolonization of infants in neonatal intensive care units. Pediatrics 2019;143:e20181565. doi: 10.1542/peds.2018-1565.CrossRefGoogle ScholarPubMed
Akinboyo, IC, Voskertchian, A, Gorfu, G, Betz, JF, Ross, TL, Carroll, KC, Milstone, AM. Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU. Infect Control Hosp Epidemiol 2018;39:13341339. doi: 10.1017/ice.2018.223.CrossRefGoogle ScholarPubMed
Milstone, AM, Voskertchian, A, Koontz, DW, et al. Effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the intensive care unit: a randomized clinical trial. JAMA 2020;323:319328. doi: 10.1001/jama.2019.20785.CrossRefGoogle ScholarPubMed
Stamatakis, A. RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. J. Bioinform 2014;30:13121313 CrossRefGoogle ScholarPubMed
Wick, RR, Judd, LM, Gorrie, CL, Holt, KE. Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. PLos Comput Biol 2017;13:e1005595CrossRefGoogle Scholar
Schürch, AC, Arredondo-Alonso, S, Willems, RJL, Goering, RV. Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene-based approaches. Clin Microbiol Infect 2018;24:350354. doi: 10.1016/j.cmi.2017.12.016 CrossRefGoogle ScholarPubMed