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Rapid Inactivation of Infectious Pathogens by Chlorhexidine-Coated Gloves

Published online by Cambridge University Press:  21 June 2016

Shanta Modak ,
Lester Sampath ,
Harvey S.S. Miller  and
Irving Millman
Shanta Modak*
Affiliation:
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York
Lester Sampath
Affiliation:
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York
Harvey S.S. Miller
Affiliation:
Daltex Medical Sciences, Inc., Fairfield, New Jersey
Irving Millman
Affiliation:
Fox Chase Cancer Center, Divisions of Population, Oncology, and Clinical Research, Philadelphia, Annsylvania
*
Dept. of Surgery, Black Bldg. Rm. 1734, Columbia University, College of Physicians and Surgeons, 630 W 168th St., New York, NY 10032
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Abstract

Objective:

Gloves containing chlorhexidine gluconate in an instant-release matrix on their inner surface (CHG gloves) were tested to determine their ability to rapidly inactivate infectious pathogens that may permeate or leak through the latex surface.

Design:

CHG gloves were exposed for 1 to 10 minutes to blood or media containing infectious pathogens (e.g., bacteria, fungi, parasites, and viruses) as well as to lymphocytes and macrophages that are known to be the primary carriers of human immunodeficiency virus (HIV). Inactivation of pathogens was determined either by in vitro assay or in vivo infectivity. Stressed control and CHG glove fingers were submerged in a viral pool (retrovirus or bacteriophage) and after a set time, the glove interiors were checked for presence of permeated viz-ions.

Results:

CHG gloves rapidly inactivate all the pathogens tested including retrovirus and hepatitis B virus (90% to 100%). In the stressed glove fingers, live virus was detected in 26% of the control group but not in any of the CHG group.

Conclusions:

The use of CHG gloves may reduce the risk of exposure to infectious fluidborne pathogens should the integrity of the latex barrier be compromised by overt failure or by permeation of viruses. Rapid destruction of lymphocytes and macrophages may facilitate inactivation of HIV associated with these cells. Tests have shown that CHG coating does not alter physical properties of the glove, and, furthermore, CHG gloves do not show potential for dermal irritation or sensitization.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 13 , Issue 8 , August 1992 , pp. 463 - 471
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1992

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