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A Randomized Controlled Trial of 1% Aqueous Chlorhexidine Gluconate Compared with 10% Povidone-Iodine for Topical Antiseptic in Neonates Effects on Blood Culture Contamination Rates

Published online by Cambridge University Press:  02 January 2015

Pracha Nuntnarumit*
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Nartsiri Sangsuksawang
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 road, Bangkok, Thailand. 10400 ([email protected])

Abstract

We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone–iodine (PI) as a topical antiseptic. We found 1% CHG to be more effective than 1% PI in reducing blood culture contamination rates, and no contact dermatitis was observed.

Type
Concise Communication
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2013

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References

1.Bates, DW, Goldman, L, Lee, TH. Contaminant blood cultures and resource utilization: the true consequences of false-positive results. JAMA 1991;265:365369.Google Scholar
2.Suwanpimolkul, G, Pongkumpai, M, Suankratay, C. A randomized trial of 2% chlorhexidine tincture compared with 10% aqueous povidone-iodine for venipuncture site disinfection: effects on blood culture contamination rates. J Infect 2008;56:354359.Google Scholar
3.Linder, N, Prince, S, Barzilai, A, et al.Disinfection with 10% povidone-iodine versus 0.5% chlorhexidine gluconate in 70% isopropanol in the neonatal intensive care unit. Acta Paediatr 2004;93:205210.Google Scholar
4.Lim, KS, Kam, PC. Chlorhexidine-pharmacology and clinical applications. Anaesth Intensive Care 2008;36:502512.Google Scholar
5.Caldeira, D, David, C, Sampaio, C. Skin antiseptics in venous puncture-site disinfection for prevention of blood culture contamination: systematic review with meta-analysis. J Hosp Infect 2011;77:223232.CrossRefGoogle ScholarPubMed
6.Chaiyakunapruk, N, Veenstra, DL, Lipsky, BA, Saint, S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792801.Google Scholar
7.O'Grady, NP, Alexander, M, Burns, LA, et al.Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control 2011;39:S1S34.CrossRefGoogle ScholarPubMed
8.Chapman, AK, Aucott, SW, Milstone, AM. Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant. J Perinatol 2012;32:49.Google Scholar
9.Garland, JS, Alex, CP, Mueller, CD, Cisler-Kahill, LA. Local reactions to a chlorhexidine gluconate-impregnated antimicrobial dressing in very low birth weight infants. Pediatr Infect Dis J 1996;15:912914.Google Scholar
10.Reynolds, PR, Banerjee, S, Meek, JH. Alcohol burns in extremely low birthweight infants: still occurring. Arch Dis Child Fetal Neonatal Ed 2005;90:F10.Google Scholar