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A Quality Assurance Program for Human Immunodeficiency Virus Seropositivity Screening of Dried-Blood Spot Specimens

Published online by Cambridge University Press:  21 June 2016

W. Harry Hannon ,
D. Sue Lewis ,
Wanda K. Jones  and
Mary K. Powell
W. Harry Hannon*
Affiliation:
Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, CA 30333
D. Sue Lewis
Affiliation:
Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, CA 30333
Wanda K. Jones
Affiliation:
Division of Training, Training and Laboratory Program Office, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, CA 30333
Mary K. Powell
Affiliation:
Division of Environmental Health Laboratory Sciences, Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, CA 30333
*
Division of Environmental Health Laboratory Sciences, Center for Environmental Health, Centers for Disease Control, Atlanta, CA 30333
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Abstract

Epidemiologic projects have been implemented for using dried-blood spot (DBS) specimens routinely collected on filter paper from neonates as a seroepidemiologic resource to monitor seroprevalence of human immunodeficiency virus (HIV) among child-bearing women. To ensure the quality of the data base produced from the national and other epidemiologic surveys, a quality assurance program was developed to interact with all the neonatal screening laboratories. The focus of the Centers for Disease Control's quality assurance program for HIV seropositivity testing of neonatal blood specimens is to maintain a national program to produce, certify, and provide external quality control materials as DBSs on filter paper, to monitor the filter paper matrix, to operate an external performance surveillance program, and to provide other special and consultative services. The dried-blood control and surveillance materials are certified by rigorous testing for accuracy, stability, and homogeneity. Preliminary results from the first performance evaluation of screening laboratories indicated excellent performance.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 10 , Issue 1 , January 1989 , pp. 8 - 13
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1989

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