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The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients

Published online by Cambridge University Press:  08 April 2016

Marie-Paule Fernandez-Gerlinger ,
Anne-Sophie Jannot ,
Sophie Rigaudeau ,
Juliette Lambert ,
Odile Eloy ,
François Mignon ,
Hassan Farhat ,
Sylvie Castaigne ,
Jacques Merrer  and
Philippe Rousselot
Marie-Paule Fernandez-Gerlinger*
Affiliation:
Service de Biologie Médicale, Centre Hospitalier de Versailles, Le Chesnay, France
Anne-Sophie Jannot
Affiliation:
Service d’informatique médicale, de biostatistique et de Santé Publique, Hôpital européen Georges Pompidou, AP-HP, Paris, France Faculté de Médecine Paris Descartes, Université Paris Descartes, Paris, France INSERM, Centre de Recherche des Cordeliers, UMRS 1138
Sophie Rigaudeau
Affiliation:
Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
Juliette Lambert
Affiliation:
Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France Université Versailles Saint-Quentin-en-Yvelines, Versailles, France
Odile Eloy
Affiliation:
Service de Biologie Médicale, Centre Hospitalier de Versailles, Le Chesnay, France
François Mignon
Affiliation:
Service de Radiologie, Centre Hospitalier de Versailles, Le Chesnay, France
Hassan Farhat
Affiliation:
Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
Sylvie Castaigne
Affiliation:
Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France Université Versailles Saint-Quentin-en-Yvelines, Versailles, France
Jacques Merrer
Affiliation:
Service de Prévention du Risque Infectieux, Centre Hospitalier de Versailles, Le Chesnay, France
Philippe Rousselot
Affiliation:
Service d’Hématologie et d’Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France Université Versailles Saint-Quentin-en-Yvelines, Versailles, France
*
Address correspondence to Marie-Paule Fernandez-Gerlinger, MD, Unité Mobile de Microbiologie Clinique, Service de Microbiologie, Hôpital européen Georges Pompidou (AP-HP), 20 rue Leblanc, 75015 Paris Cedex, France ([email protected]).
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Abstract

OBJECTIVE

Invasive aspergillosis (IA) is a rare but severe infection caused by Aspergillus spp. that often develops in immunocompromised patients. Lethality remains high in this population. Therefore, preventive strategies are of key importance. The impact of a mobile air decontamination system (Plasmair, AirInSpace, Montigny-le-Bretonneux, France) on the incidence of IA in neutropenic patients was evaluated in this study.

DESIGN

Retrospective cohort study

METHODS

Patients with chemotherapy-induced neutropenia lasting 7 days or more were included over a 2-year period. Cases of IA were confirmed using the revised European Organization for Research and Treatment of Cancer (EORTC) criteria. We took advantage of a partial installation of Plasmair systems in the hematology intensive care unit during this period to compare patients treated in Plasmair-equipped versus non-equipped rooms. Patients were assigned to Plasmair-equipped or non-equipped rooms depending only on bed availability. Differences in IA incidence in both groups were compared using Fisher’s exact test, and a multivariate analysis was performed to take into account potential confounding factors.

RESULTS

Data from 156 evaluable patients were available. Both groups were homogenous in terms of age, gender, hematological diagnosis, duration of neutropenia, and prophylaxis. A total of 11 cases of probable IA were diagnosed: 10 in patients in non-equipped rooms and only 1 patient in a Plasmair-equipped room. The odds of developing IA were much lower for patients hospitalized in Plasmair-equipped rooms than for patients in non-equipped rooms (P=.02; odds ratio [OR] =0.11; 95% confidence interval [CI], 0.00–0.84).

CONCLUSION

In this study, Plasmair demonstrated a major impact in reducing the incidence of IA in neutropenic patients with hematologic malignancies.

Infect Control Hosp Epidemiol 2016;37:845–851

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 37 , Issue 7 , July 2016 , pp. 845 - 851
Copyright
© 2016 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION. The data from this study were presented at the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) on April 26, 2015, in Copenhagen, Denmark.

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